ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
- Product Name
- ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
- CAS No.
- 7238-62-2
- Chemical Name
- ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
- Synonyms
- 2-Chloro-4-methyl-5-ethoxycarbonylthiazole;Ethyl 2-chloro-4-methyl-5-thiazolecarboxylate;ETHYL 2-CHLORO-4-METHYLTHIAZOLE-5-CARBOXYLATE;ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate 97%;2-Chloro-4-methylthiazole-5-carboxylic acid ethyl ester;Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate ,97%;2-Chloro-4-methyl-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 2-chloro-4-methyl-, ethyl ester
- CBNumber
- CB3352092
- Molecular Formula
- C7H8ClNO2S
- Formula Weight
- 205.66
- MOL File
- 7238-62-2.mol
ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Property
- Melting point:
- 46 °C
- Boiling point:
- 116℃
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. -20°C
- pka
- -0.10±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Note
- Harmful
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- E937138
- Product name
- Ethyl2-Chloro-4-methylthiazole-5-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W006589
- Product name
- Ethyl2-chloro-4-methylthiazole-5-carboxylate
- Purity
- 96.11%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- OR9735
- Product name
- Ethyl2-chloro-4-methyl-1,3-thiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- OR9735
- Product name
- Ethyl2-chloro-4-methyl-1,3-thiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 8H23-5-03
- Product name
- Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production
Definition
ChEBI: Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate is an aromatic carboxylic acid and a member of thiazoles.
Synthesis
40235-78-7
7238-62-2
Intermediate Example L; Synthesis of ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate (X-1): ethyl 2-oxo-4-methyl-3H-thiazole-5-carboxylate (0.57 g, 3.05 mmol) was mixed with phosphorus triclosan (5 mL) and heated to react for 18 hours at 120°C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove excess phosphorous trichloride. Water (15 mL) was slowly added to the residue and stirred for 10 minutes. The aqueous phase was extracted with ether (3 x 15 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (ethyl acetate/hexane as eluent) to afford ethyl 2-chloro-4-methylthiazole-5-carboxylate as a white solid (0.54 g, 86% yield).1H NMR (400 MHz, CDCl3) δ 4.32 (q, J = 7.1 Hz, 2H), 2.68 (s, 3H), 1.35 (t, J = 7.1 Hz, 3H). 3H).
References
[1] Journal of Heterocyclic Chemistry, 1985, vol. 22, p. 1621 - 1630
[2] Patent: WO2005/51890, 2005, A1. Location in patent: Page/Page column 67-68
[3] Proceedings - Indian Academy of Sciences, Section A, 1945, # 22, p. 362,376
[4] Patent: US5817829, 1998, A
ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 0510-0510-83593305
- Fax
- 0086-510-83593305
- sales@huifeichem.com
- Country
- China
- ProdList
- 102
- Advantage
- 62
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3992
- Advantage
- 55
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55