ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
- Product Name
- ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
- CAS No.
- 72850-52-3
- Chemical Name
- ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
- Synonyms
- Ethyl 2-chloro-4-(trifluoroMethyl)thiazole-5-carboxylate;ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE;2-chloro-4-trifluoromethyl-thiazol-5-carboxylic acid-ethyl ester;2-CHLORO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;2-chloro-4-(trifluoromethyl)-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, ethyl ester
- CBNumber
- CB3109311
- Molecular Formula
- C7H5ClF3NO2S
- Formula Weight
- 259.63
- MOL File
- 72850-52-3.mol
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Property
- Melting point:
- 57-59
- Boiling point:
- 308.7±52.0 °C(Predicted)
- Density
- 1.509±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.03±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- PC14280
- Product name
- Ethyl2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
- Packaging
- 100mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 8H70-7-X0
- Product name
- Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
- Packaging
- 100mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 8835AE
- Product name
- Ethyl2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $286
- Updated
- 2021/12/16
- Product number
- PC14280
- Product name
- Ethyl2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- 8H70-7-X0
- Product name
- Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
344-72-9
110-46-3
72850-52-3
General procedure: preparation of ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate; ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate (1.0 g, 4.16 mmol) was slowly added to CuCl2 (671 mg, 4.99 mmol) and isoamyl nitrite (732 mg, 6.24 mmol) in acetonitrile (10 ml) at 0°C in a in the mixture. The reaction mixture was stirred at room temperature for 1 hour and then heated to 50 °C to continue the reaction for 1 hour. After completion of the reaction, most of the solvent was removed under reduced pressure and the residue was poured into a mixture of ice and concentrated hydrochloric acid. The mixture was extracted with dichloromethane, the organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast silica gel column chromatography (eluent: hexane/ethyl acetate = 20:1) to afford the target compound ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate (762 mg, 71% yield).1H NMR (300 MHz, DMSO-d6) δ 1.26 (t, J=7.0 Hz, 3H), 4.31 (q, J=7.0 Hz, 2H).
References
[1] Patent: WO2010/56588, 2010, A1. Location in patent: Page/Page column 13
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE manufacturers
- Product
- ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE 72850-52-3
- Price
- US $1.60-9.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
- Product
- 5-(trifluoromethyl)thiazol-2-amine 72850-52-3
- Price
- US $12.00/Kg/Bag
- Min. Order
- 25Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-11-13