ChemicalBook > CAS DataBase List > ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE

Product Name
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
CAS No.
72850-52-3
Chemical Name
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
Synonyms
Ethyl 2-chloro-4-(trifluoroMethyl)thiazole-5-carboxylate;ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE;2-chloro-4-trifluoromethyl-thiazol-5-carboxylic acid-ethyl ester;2-CHLORO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;2-chloro-4-(trifluoromethyl)-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, ethyl ester
CBNumber
CB3109311
Molecular Formula
C7H5ClF3NO2S
Formula Weight
259.63
MOL File
72850-52-3.mol
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ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Property

Melting point:
57-59
Boiling point:
308.7±52.0 °C(Predicted)
Density 
1.509±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-4.03±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC14280
Product name
Ethyl2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
Packaging
100mg
Price
$79
Updated
2021/12/16
SynQuest Laboratories
Product number
8H70-7-X0
Product name
Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
Packaging
100mg
Price
$87
Updated
2021/12/16
AK Scientific
Product number
8835AE
Product name
Ethyl2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
Packaging
250mg
Price
$286
Updated
2021/12/16
Apolloscientific
Product number
PC14280
Product name
Ethyl2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
Packaging
250mg
Price
$127
Updated
2021/12/16
SynQuest Laboratories
Product number
8H70-7-X0
Product name
Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
Packaging
250mg
Price
$140
Updated
2021/12/16
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ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

344-72-9

110-46-3

72850-52-3

General procedure: preparation of ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate; ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate (1.0 g, 4.16 mmol) was slowly added to CuCl2 (671 mg, 4.99 mmol) and isoamyl nitrite (732 mg, 6.24 mmol) in acetonitrile (10 ml) at 0°C in a in the mixture. The reaction mixture was stirred at room temperature for 1 hour and then heated to 50 °C to continue the reaction for 1 hour. After completion of the reaction, most of the solvent was removed under reduced pressure and the residue was poured into a mixture of ice and concentrated hydrochloric acid. The mixture was extracted with dichloromethane, the organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast silica gel column chromatography (eluent: hexane/ethyl acetate = 20:1) to afford the target compound ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate (762 mg, 71% yield).1H NMR (300 MHz, DMSO-d6) δ 1.26 (t, J=7.0 Hz, 3H), 4.31 (q, J=7.0 Hz, 2H).

References

[1] Patent: WO2010/56588, 2010, A1. Location in patent: Page/Page column 13

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE 72850-52-3
Price
US $1.60-9.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-20
Longyan Tianhua Biological Technology Co., Ltd
Product
5-(trifluoromethyl)thiazol-2-amine 72850-52-3
Price
US $12.00/Kg/Bag
Min. Order
25Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-11-13

72850-52-3, ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATERelated Search:

METHYL 2-CHLORO-4-THIAZOLECARBOXYLATE ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-CHLORO-4-METHYL-THIAZOLE ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE 2-CHLORO-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE

  • 2-chloro-4-trifluoromethyl-thiazol-5-carboxylic acid-ethyl ester
  • ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
  • 2-CHLORO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
  • Ethyl 2-chloro-4-(trifluoroMethyl)thiazole-5-carboxylate
  • 2-chloro-4-(trifluoromethyl)-5-thiazolecarboxylic acid ethyl ester
  • 5-Thiazolecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, ethyl ester
  • 72850-52-3
  • C7H5ClF3NO2S