2-Chlorothiazole
Application- Product Name
- 2-Chlorothiazole
- CAS No.
- 3034-52-4
- Chemical Name
- 2-Chlorothiazole
- Synonyms
- orothiazoL;2-CHLOTHIOZOLE;2-CHLOROTHIAZOLE;2-CHLOROTHIOZOLE;Thiazole, 2-chloro-;2-Chlorothiazole,97%;2-Thiazolyl Chloride;2-Chlorothiazole 96%;2-Chlorothiazole >2-CHLORO-1,3-THIAZOLE
- CBNumber
- CB3752078
- Molecular Formula
- C3H2ClNS
- Formula Weight
- 119.57
- MOL File
- 3034-52-4.mol
2-Chlorothiazole Property
- Melting point:
- 85 °C
- Boiling point:
- 145 °C
- Density
- 1.393 g/mL at 25 °C
- refractive index
- n20/D1.551
- Flash point:
- 54℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- soluble in Ether
- form
- clear liquid
- pka
- 0.84±0.10(Predicted)
- color
- Colorless to Almost colorless
- InChI
- InChI=1S/C3H2ClNS/c4-3-5-1-2-6-3/h1-2H
- InChIKey
- KLEYVGWAORGTIT-UHFFFAOYSA-N
- SMILES
- S1C=CN=C1Cl
- CAS DataBase Reference
- 3034-52-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-41-22-10
- Safety Statements
- 23-26-36/37/39-39
- RIDADR
- 1993
- WGK Germany
- 1
- HazardClass
- 3
- PackingGroup
- Ⅲ
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C2471
- Product name
- 2-Chlorothiazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- C2471
- Product name
- 2-Chlorothiazole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $143
- Updated
- 2025/07/31
- Product number
- C364478
- Product name
- 2-Chlorothiazole
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- COR0001765
- Product name
- 2-CHLOROTHIAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $122.56
- Updated
- 2021/12/16
- Product number
- W5278
- Product name
- 2-Chlorothiazole
- Packaging
- 250mg
- Price
- $208
- Updated
- 2021/12/16
2-Chlorothiazole Chemical Properties,Usage,Production
Application
2-Chlorothiazole is a pharmaceutical intermediate that can be prepared from 2-aminothiazole via a diazotization reaction. Literature reports that it can be used to prepare substituted tyrosine inhibitors containing zinc-binding genes, such as N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide.
Chemical Properties
Pale yellow liquid
Definition
ChEBI: 2-chlorothiazole is a member of 1,3-thiazoles and an organochlorine compound.
Reactivity Profile
Halogen atoms in the 4- and 5-positions of thiazoles exhibit different reactivities depending on the nucleophile: with methoxide ion in methanol the reactivity sequence is 5-chlorothiazole > 2-chlorothiazole > 4-chlorothiazole. In contrast, with thiophenoxide ion or piperidine in methanol, the sequence 2 > 4 > 5 is observed. With the series of alkoxide ions methoxide, ethoxide, isopropoxide and t-butoxide in the corresponding alcohol, the reactivity ratios of 4-chlorothiazole versus 2-chlorothiazole are: 0.07, 0.6, 4, 42. The nucleophilic reactivity of 2-halogenothiazoles is strongly affected by substituents: 2-chloro-5-nitrothiazole is more reactive than 2-chlorothiazole by a factor of 10.
Synthesis
288-47-1
3034-52-4
General procedure for the synthesis of 2-chlorothiazole from thiazole: To an anhydrous THF (60 mL) solution of thiazole (5.0 g, 58.7 mmol) was added n-butyllithium (1.6 M hexane solution, 44 mL, 70.4 mmol) slowly and dropwise over a period of 20 min at -78 °C with stirring. The reaction mixture was kept at 0 °C for 15 min, followed by dropwise addition of anhydrous THF (40 mL) solution of 2,2,2-trichloroacetyl chloride (6.6 mL, 58.7 mmol) to the orange colored mixture. The reaction mixture was continued to be stirred at -78 °C for 30 min, after which the reaction was quenched with saturated ammonium chloride solution (100 mL). After extraction with ether (2 x 150 mL), the organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (0-20% ether/pentane gradient elution) to afford the target compound 2-chlorothiazole (4.95 g, isolated yield 71%).1H NMR (400 MHz, CDCl3) δ 7.50 (d, J=4.0 Hz, 1H), 7.15 (d, J=4.0 Hz, 1H).
References
[1] Patent: WO2008/150446, 2008, A1. Location in patent: Page/Page column 29
[2] Journal of Organometallic Chemistry, 1999, vol. 588, # 2, p. 155 - 159
[3] Journal of Organometallic Chemistry, 2000, vol. 601, # 2, p. 233 - 236
2-Chlorothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chlorothiazole manufacturers
- Product
- 2-Chlorothiazole 3034-52-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-26
- Product
- 2-Chlorothiazole 3034-52-4
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-12-04
- Product
- 2-Chlorothiazole 3034-52-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-20