ChemicalBook > CAS DataBase List > 2-Chlorothiazole

2-Chlorothiazole

Application

Product Name: 2-Chlorothiazole
CAS No.: 3034-52-4
Chemical Name: 2-Chlorothiazole
Synonyms: orothiazoL;2-CHLOTHIOZOLE;2-CHLOROTHIAZOLE;2-CHLOROTHIOZOLE;Thiazole, 2-chloro-;2-Chlorothiazole,97%;2-Thiazolyl Chloride;2-Chlorothiazole 96%;2-Chlorothiazole >2-CHLORO-1,3-THIAZOLE
CBNumber: CB3752078
Molecular Formula: C3H2ClNS
Formula Weight: 119.57
MOL File: 3034-52-4.mol

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2-Chlorothiazole Property

Melting point:: 85 °C
Boiling point:: 145 °C
Density: 1.393 g/mL at 25 °C
refractive index: n20/D1.551
Flash point:: 54℃
storage temp.: Inert atmosphere,2-8°C
solubility: soluble in Ether
form: clear liquid
pka: 0.84±0.10(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C3H2ClNS/c4-3-5-1-2-6-3/h1-2H
InChIKey: KLEYVGWAORGTIT-UHFFFAOYSA-N
SMILES: S1C=CN=C1Cl
CAS DataBase Reference: 3034-52-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-41-22-10
Safety Statements: 23-26-36/37/39-39
RIDADR: 1993
WGK Germany: 1
HazardClass: 3
PackingGroup: Ⅲ
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2471
Product name: 2-Chlorothiazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $48
Updated: 2025/07/31

TCI Chemical

Product number: C2471
Product name: 2-Chlorothiazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $143
Updated: 2025/07/31

TRC

Product number: C364478
Product name: 2-Chlorothiazole
Packaging: 100mg
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0001765
Product name: 2-CHLOROTHIAZOLE
Purity: 95.00%
Packaging: 1G
Price: $122.56
Updated: 2021/12/16

AK Scientific

Product number: W5278
Product name: 2-Chlorothiazole
Packaging: 250mg
Price: $208
Updated: 2021/12/16

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2-Chlorothiazole Chemical Properties,Usage,Production

Application

2-Chlorothiazole is a pharmaceutical intermediate that can be prepared from 2-aminothiazole via a diazotization reaction. Literature reports that it can be used to prepare substituted tyrosine inhibitors containing zinc-binding genes, such as N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide.

Chemical Properties

Pale yellow liquid

Definition

ChEBI: 2-chlorothiazole is a member of 1,3-thiazoles and an organochlorine compound.

Reactivity Profile

Halogen atoms in the 4- and 5-positions of thiazoles exhibit different reactivities depending on the nucleophile: with methoxide ion in methanol the reactivity sequence is 5-chlorothiazole > 2-chlorothiazole > 4-chlorothiazole. In contrast, with thiophenoxide ion or piperidine in methanol, the sequence 2 > 4 > 5 is observed. With the series of alkoxide ions methoxide, ethoxide, isopropoxide and t-butoxide in the corresponding alcohol, the reactivity ratios of 4-chlorothiazole versus 2-chlorothiazole are: 0.07, 0.6, 4, 42. The nucleophilic reactivity of 2-halogenothiazoles is strongly affected by substituents: 2-chloro-5-nitrothiazole is more reactive than 2-chlorothiazole by a factor of 10.

Synthesis

288-47-1

3034-52-4

General procedure for the synthesis of 2-chlorothiazole from thiazole: To an anhydrous THF (60 mL) solution of thiazole (5.0 g, 58.7 mmol) was added n-butyllithium (1.6 M hexane solution, 44 mL, 70.4 mmol) slowly and dropwise over a period of 20 min at -78 °C with stirring. The reaction mixture was kept at 0 °C for 15 min, followed by dropwise addition of anhydrous THF (40 mL) solution of 2,2,2-trichloroacetyl chloride (6.6 mL, 58.7 mmol) to the orange colored mixture. The reaction mixture was continued to be stirred at -78 °C for 30 min, after which the reaction was quenched with saturated ammonium chloride solution (100 mL). After extraction with ether (2 x 150 mL), the organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (0-20% ether/pentane gradient elution) to afford the target compound 2-chlorothiazole (4.95 g, isolated yield 71%).1H NMR (400 MHz, CDCl3) δ 7.50 (d, J=4.0 Hz, 1H), 7.15 (d, J=4.0 Hz, 1H).

References

[1] Patent: WO2008/150446, 2008, A1. Location in patent: Page/Page column 29
[2] Journal of Organometallic Chemistry, 1999, vol. 588, # 2, p. 155 - 159
[3] Journal of Organometallic Chemistry, 2000, vol. 601, # 2, p. 233 - 236

2-Chlorothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chlorothiazole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chlorothiazole 3034-52-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-26

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Chlorothiazole 3034-52-4
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-04

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chlorothiazole 3034-52-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-20

3034-52-4, 2-ChlorothiazoleRelated Search:

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Thiazole 2,2'-Dithiobis(benzothiazole) Fosthiazate Benzothiazole Epichlorohydrin 2-(2-Aminothiazol-4-yl)glyoxylic acid 2-Mercaptobenzothiazole 2-Chlorobenzothiazole Difluorochloromethane 2,6-Dichlorobenzothiazole 2-Chloro-6-nitrobenzothiazole 2-CHLORO-4-METHYL-THIAZOLE Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI) 2,4-Dichlorobenzothiazole Chloroacetic acid 2-Chloro-6-methoxybenzothiazole 2,4-Dichloro-5-thiazolecarboxaldehyde

2-CHLOROTHIAZOLE

2-CHLORO-1,3-THIAZOLE

2-CHLOROTHIOZOLE

2-CHLOTHIOZOLE

2-CHLOROTHIAZOLE, 95+%

1-BENZYLPYRROLIDINE-3-CARBOXYAMIDE

Thiazole, 2-chloro-

2-Chlorothiazole 96%

2-Thiazolyl Chloride

2-Chlorothiazole,97%

orothiazoL

2-Chloro-1,3-thiazole 98%

2-Chlorothiazole &gt

3034-52-4

3034-53-4

C3H2ClNS

Miscellaneous Heterocycle

Thiazoles, Isothiazoles & Benzothiazoles

Thiazole series

Halides

Thiazoles, Isothiazoles &Benzothiazoles

Thiazoles, Isothiazoles & Benzothiazoles