ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
- Product Name
- ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
- CAS No.
- 41731-52-6
- Chemical Name
- ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
- Synonyms
- Ethyl 2-chloro-4-thiazolecarboxylate;ETHYL 2-CHLOROTHIAZOLE-4-CARBOXYLATE;2-Chloro-4-(ethoxycarbonyl)-1,3-thiazole;ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE;2-Chlorothiazole-4-carboxylic acid ethyl ester;2-chloro-4-Thiazolecarboxylic acid ethyl ester;2-Chloro-thiazole-4-carboxylic acid Methyl ester;4-Thiazolecarboxylic acid, 2-chloro-, ethyl ester
- CBNumber
- CB71517960
- Molecular Formula
- C6H6ClNO2S
- Formula Weight
- 191.64
- MOL File
- 41731-52-6.mol
ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Property
- Boiling point:
- 283.9℃
- Density
- 1.383
- Flash point:
- 125.5℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.50±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C6H6ClNO2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3
- InChIKey
- GILVNZWYCBUGMT-UHFFFAOYSA-N
- SMILES
- S1C=C(C(OCC)=O)N=C1Cl
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B124780
- Product name
- Ethyl 2-chlorothiazole-4-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B124780
- Product name
- Ethyl 2-chlorothiazole-4-carboxylate
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- P000167533
- Product name
- Ethyl 2-chlorothiazole-4-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $7
- Updated
- 2021/12/16
- Product number
- P000167533
- Product name
- Ethyl 2-chlorothiazole-4-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- C11740
- Product name
- 2-Chlorothiazole-4-carboxylicacidethylester
- Purity
- 95%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
5398-36-7
41731-52-6
General procedure for the synthesis of ethyl 2-chlorothiazole-4-carboxylate from ethyl 2-aminothiazole-4-carboxylate: ethyl 2-aminothiazole-4-carboxylate (306 mg, 1.78 mmol) and cuprous chloride (CuCl, 238 mg, 2.4 mmol) were suspended in concentrated hydrochloric acid (8 mL). The mixture was cooled in a salt/ice bath. A solution of pre-cooled sodium nitrite (NaNO2, 166 mg, 2.4 mmol) in water (2 mL) was added slowly over 10 minutes. The reaction mixture was allowed to gradually warm up to room temperature over 1 h and stirring was continued for 1 h. The reaction mixture was allowed to warm up to room temperature over 1 h and stirring was continued for 1 h. Upon completion of the reaction, water was added to dilute it and the aqueous phase was extracted with ethyl acetate (EtOAc, 3 x 10 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the target product ethyl 2-chlorothiazole-4-carboxylate. Yield: 251 mg, 74% yield; liquid chromatography-mass spectrometry (LC/MS) retention time (tr) 1.06 min; mass spectrometry (electrospray positive ionization mode, ES+) m/z 192, 194 ([M+H]+); 1H NMR (250 MHz, CDCl3) δ 1.41 (t, 3H), 4.43 (q, 2H), 8.08 (s, 1H). 1H).
References
[1] Patent: WO2005/80367, 2005, A1. Location in patent: Page/Page column 109
[2] Organic Letters, 2013, vol. 15, # 20, p. 5390 - 5393
[3] Patent: US2013/178470, 2013, A1. Location in patent: Paragraph 0106
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 5764 - 5768
[5] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433
ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE manufacturers
- Product
- Ethyl 2-chloro-1,3-thiazole-4-carboxylate 41731-52-6
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE 41731-52-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-14