ChemicalBook > CAS DataBase List > ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE

ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE

Product Name
ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
CAS No.
41731-52-6
Chemical Name
ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
Synonyms
Ethyl 2-chloro-4-thiazolecarboxylate;ETHYL 2-CHLOROTHIAZOLE-4-CARBOXYLATE;2-Chloro-4-(ethoxycarbonyl)-1,3-thiazole;ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE;2-Chlorothiazole-4-carboxylic acid ethyl ester;2-chloro-4-Thiazolecarboxylic acid ethyl ester;2-Chloro-thiazole-4-carboxylic acid Methyl ester;4-Thiazolecarboxylic acid, 2-chloro-, ethyl ester
CBNumber
CB71517960
Molecular Formula
C6H6ClNO2S
Formula Weight
191.64
MOL File
41731-52-6.mol
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ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Property

Boiling point:
283.9℃
Density 
1.383
Flash point:
125.5℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.50±0.10(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C6H6ClNO2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3
InChIKey
GILVNZWYCBUGMT-UHFFFAOYSA-N
SMILES
S1C=C(C(OCC)=O)N=C1Cl
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B124780
Product name
Ethyl 2-chlorothiazole-4-carboxylate
Packaging
500mg
Price
$110
Updated
2021/12/16
TRC
Product number
B124780
Product name
Ethyl 2-chlorothiazole-4-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Ark Pharm
Product number
P000167533
Product name
Ethyl 2-chlorothiazole-4-carboxylate
Purity
95%
Packaging
5g
Price
$74
Updated
2021/12/16
Matrix Scientific
Product number
057465
Product name
Ethyl 2-chlorothiazole-4-carboxylate
Purity
97%
Packaging
25g
Price
$278
Updated
2021/12/16
AK Scientific
Product number
9712AF
Product name
2-Chlorothiazole-4-carboxylicacidethylester
Packaging
25g
Price
$425
Updated
2021/12/16
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ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

5398-36-7

41731-52-6

General procedure for the synthesis of ethyl 2-chlorothiazole-4-carboxylate from ethyl 2-aminothiazole-4-carboxylate: ethyl 2-aminothiazole-4-carboxylate (306 mg, 1.78 mmol) and cuprous chloride (CuCl, 238 mg, 2.4 mmol) were suspended in concentrated hydrochloric acid (8 mL). The mixture was cooled in a salt/ice bath. A solution of pre-cooled sodium nitrite (NaNO2, 166 mg, 2.4 mmol) in water (2 mL) was added slowly over 10 minutes. The reaction mixture was allowed to gradually warm up to room temperature over 1 h and stirring was continued for 1 h. The reaction mixture was allowed to warm up to room temperature over 1 h and stirring was continued for 1 h. Upon completion of the reaction, water was added to dilute it and the aqueous phase was extracted with ethyl acetate (EtOAc, 3 x 10 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the target product ethyl 2-chlorothiazole-4-carboxylate. Yield: 251 mg, 74% yield; liquid chromatography-mass spectrometry (LC/MS) retention time (tr) 1.06 min; mass spectrometry (electrospray positive ionization mode, ES+) m/z 192, 194 ([M+H]+); 1H NMR (250 MHz, CDCl3) δ 1.41 (t, 3H), 4.43 (q, 2H), 8.08 (s, 1H). 1H).

References

[1] Patent: WO2005/80367, 2005, A1. Location in patent: Page/Page column 109
[2] Organic Letters, 2013, vol. 15, # 20, p. 5390 - 5393
[3] Patent: US2013/178470, 2013, A1. Location in patent: Paragraph 0106
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 5764 - 5768
[5] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433

ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ethyl 2-chloro-1,3-thiazole-4-carboxylate 41731-52-6
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE 41731-52-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2020-01-14

41731-52-6, ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATERelated Search:

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  • ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
  • ETHYL 2-CHLOROTHIAZOLE-4-CARBOXYLATE
  • 2-Chlorothiazole-4-carboxylic acid ethyl ester
  • Ethyl 2-chloro-4-thiazolecarboxylate
  • 2-Chloro-thiazole-4-carboxylic acid Methyl ester
  • 2-chloro-4-Thiazolecarboxylic acid ethyl ester
  • 2-Chloro-4-(ethoxycarbonyl)-1,3-thiazole
  • 4-Thiazolecarboxylic acid, 2-chloro-, ethyl ester
  • 41731-52-6
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  • Thiazole