2-Methyl-1,3-thiazole-4-carboxylic acid
- Product Name
- 2-Methyl-1,3-thiazole-4-carboxylic acid
- CAS No.
- 35272-15-2
- Chemical Name
- 2-Methyl-1,3-thiazole-4-carboxylic acid
- Synonyms
- BUTTPARK 98\06-12;CHEMBRDG-BB 4400182;RARECHEM AL BO 0660;2-Methyl-Thiazole-4-Carboxylic;4-Carboxy-2-methyl-1,3-thiazole;2-Methyl-4-thiazolecarboxylic Acid;2-METHYL-THIAZOLE-4-CARBOXYLIC ACID;4-Thiazolecarboxylic acid, 2-methyl-;2-Methylthiazole-4-carboxylic acid 97%;2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
- CBNumber
- CB5372845
- Molecular Formula
- C5H5NO2S
- Formula Weight
- 143.16
- MOL File
- 35272-15-2.mol
2-Methyl-1,3-thiazole-4-carboxylic acid Property
- Melting point:
- 148 °C
- Boiling point:
- 301.2±15.0 °C(Predicted)
- Density
- 1.418±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 4.28±0.10(Predicted)
- color
- White to Light yellow
- CAS DataBase Reference
- 35272-15-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 718440
- Product name
- 2-Methylthiazole-4-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $70.5
- Updated
- 2023/06/20
- Product number
- M2802
- Product name
- 2-Methylthiazole-4-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $99
- Updated
- 2025/07/31
- Product number
- M2802
- Product name
- 2-Methylthiazole-4-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $313
- Updated
- 2025/07/31
- Product number
- M331438
- Product name
- 2-Methyl-1,3-thiazole-4-carboxylicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M331438
- Product name
- 2-Methyl-1,3-thiazole-4-carboxylicAcid
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
2-Methyl-1,3-thiazole-4-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White to orange to tan solid
Synthesis
6436-59-5
35272-15-2
The general procedure for the synthesis of 2-methyl-4-thiazolecarboxylic acid using ethyl 2-methylthiazole-4-carboxylate as starting material is as follows: 1. dissolve ethyl 2-methylthiazole-4-carboxylate in tetrahydrofuran (THF). 2. add 10% (w/v) aqueous solution of potassium hydroxide (KOH) to the above solution. 3. The reaction mixture was stirred at room temperature until thin layer chromatography (TLC) showed complete disappearance of the raw material. 4. pH of the reaction solution was adjusted to 4 with 1 M hydrochloric acid (HCl). 5. The reaction solution was extracted with ethyl acetate (EtOAc). 6. 6. The organic phase was dried with anhydrous magnesium sulfate (MgSO?). 7. The organic phase was concentrated to give the target product 2-methyl-4-thiazolecarboxylic acid.
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 776 - 788
[2] Patent: US2007/105891, 2007, A1. Location in patent: Page/Page column 10
[3] Patent: US2006/160857, 2006, A1. Location in patent: Page/Page column 31
[4] Chemistry of Heterocyclic Compounds, 2011, vol. 47, # 6, p. 703 - 709
[5] Patent: WO2004/58702, 2004, A2. Location in patent: Page 29; 23
2-Methyl-1,3-thiazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methyl-1,3-thiazole-4-carboxylic acid manufacturers
- Product
- 2-Methyl-1,3-thiazole-4-carboxylic acid 35272-15-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-06
- Product
- 2-Methyl-1,3-thiazole-4-carboxylic acid 35272-15-2
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 2-Methyl-1,3-thiazole-4-carboxylic acid 35272-15-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-16