ChemicalBook > CAS DataBase List > 2-Methyl-1,3-thiazole-4-carboxylic acid

2-Methyl-1,3-thiazole-4-carboxylic acid

Product Name
2-Methyl-1,3-thiazole-4-carboxylic acid
CAS No.
35272-15-2
Chemical Name
2-Methyl-1,3-thiazole-4-carboxylic acid
Synonyms
BUTTPARK 98\06-12;CHEMBRDG-BB 4400182;RARECHEM AL BO 0660;2-Methyl-Thiazole-4-Carboxylic;4-Carboxy-2-methyl-1,3-thiazole;2-Methyl-4-thiazolecarboxylic Acid;2-METHYL-THIAZOLE-4-CARBOXYLIC ACID;4-Thiazolecarboxylic acid, 2-methyl-;2-Methylthiazole-4-carboxylic acid 97%;2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
CBNumber
CB5372845
Molecular Formula
C5H5NO2S
Formula Weight
143.16
MOL File
35272-15-2.mol
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2-Methyl-1,3-thiazole-4-carboxylic acid Property

Melting point:
148 °C
Boiling point:
301.2±15.0 °C(Predicted)
Density 
1.418±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
4.28±0.10(Predicted)
color 
White to Light yellow
CAS DataBase Reference
35272-15-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
2
HazardClass 
IRRITANT
HS Code 
29341000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
718440
Product name
2-Methylthiazole-4-carboxylic acid
Purity
97%
Packaging
1g
Price
$70.5
Updated
2023/06/20
TCI Chemical
Product number
M2802
Product name
2-Methylthiazole-4-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$99
Updated
2025/07/31
TCI Chemical
Product number
M2802
Product name
2-Methylthiazole-4-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$313
Updated
2025/07/31
TRC
Product number
M331438
Product name
2-Methyl-1,3-thiazole-4-carboxylicAcid
Packaging
500mg
Price
$110
Updated
2021/12/16
TRC
Product number
M331438
Product name
2-Methyl-1,3-thiazole-4-carboxylicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
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2-Methyl-1,3-thiazole-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to orange to tan solid

Synthesis

6436-59-5

35272-15-2

The general procedure for the synthesis of 2-methyl-4-thiazolecarboxylic acid using ethyl 2-methylthiazole-4-carboxylate as starting material is as follows: 1. dissolve ethyl 2-methylthiazole-4-carboxylate in tetrahydrofuran (THF). 2. add 10% (w/v) aqueous solution of potassium hydroxide (KOH) to the above solution. 3. The reaction mixture was stirred at room temperature until thin layer chromatography (TLC) showed complete disappearance of the raw material. 4. pH of the reaction solution was adjusted to 4 with 1 M hydrochloric acid (HCl). 5. The reaction solution was extracted with ethyl acetate (EtOAc). 6. 6. The organic phase was dried with anhydrous magnesium sulfate (MgSO?). 7. The organic phase was concentrated to give the target product 2-methyl-4-thiazolecarboxylic acid.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 776 - 788
[2] Patent: US2007/105891, 2007, A1. Location in patent: Page/Page column 10
[3] Patent: US2006/160857, 2006, A1. Location in patent: Page/Page column 31
[4] Chemistry of Heterocyclic Compounds, 2011, vol. 47, # 6, p. 703 - 709
[5] Patent: WO2004/58702, 2004, A2. Location in patent: Page 29; 23

2-Methyl-1,3-thiazole-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethanol Ethyl bromopyruvate Potassium hydroxide Ethyl acetate Thioacetamide

Preparation Products

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2-Methyl-1,3-thiazole-4-carboxylic acid Suppliers

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View Lastest Price from 2-Methyl-1,3-thiazole-4-carboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Methyl-1,3-thiazole-4-carboxylic acid 35272-15-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-07-06
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Methyl-1,3-thiazole-4-carboxylic acid 35272-15-2
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Shaanxi Dideu Medichem Co. Ltd
Product
2-Methyl-1,3-thiazole-4-carboxylic acid 35272-15-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-16

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  • 35272-15-2
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