2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
- Product Name
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
- CAS No.
- 1152475-50-7
- Chemical Name
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
- Synonyms
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine;5H-Pyrrolo[3,2-d]pyrimidine, 2-chloro-7-iodo-;2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB72471270
- Molecular Formula
- C6H3ClIN3
- Formula Weight
- 279.47
- MOL File
- 1152475-50-7.mol
2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine Property
- Density
- 2.284
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- light yellow solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C366948
- Product name
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 073290
- Product name
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $722
- Updated
- 2021/12/16
- Product number
- X9113
- Product name
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 250mg
- Price
- $1024
- Updated
- 2021/12/16
- Product number
- 073290
- Product name
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1557
- Updated
- 2021/12/16
- Product number
- 073290
- Product name
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $4427
- Updated
- 2021/12/16
2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
1119280-66-8
1152475-50-7
General procedure for the synthesis of 2-chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine using 2-chloro-5H-pyrrolo[3,2-d]pyrimidine as a raw material: to an aqueous (200 mL) suspension of 2-chloro-5H-pyrrolo[3,2-d]pyrimidine (3.55 g, 23.2 mmol) was added, in order, sodium bicarbonate (19.2 g), potassium iodide (16.41 g, 98.9 mmol). Subsequently, a solution of iodine (5.78 g, 22.8 mmol) in water (25 mL) was added dropwise, and the reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction mixture was diluted with saturated saline and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by fast column chromatography with chloroform/methanol (25:1 to 20:1, v/v) as eluent to afford the target compound 2-chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine (5.33 g, 83% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 300 MHz) and 13C NMR (DMSO-d6, 75 MHz): 1H NMR δ 12.50 (s, 1H), 8.82 (s, 1H), 8.20 (s, 1H); 13C NMR δ 143.2, 143.0, 139.7, 139.5, 126.5, 56.2. Mass spectrometry (EMS) was performed on the product. 56.2. Results of mass spectrometry (EI) analysis: m/z calculated values [M]+ 278.91, 280.91, measured values 278.95, 280.95.
References
[1] Patent: WO2009/62258, 2009, A1. Location in patent: Page/Page column 99
[2] Patent: US2016/46597, 2016, A1. Location in patent: Paragraph 0221
[3] Journal of Medicinal Chemistry, 2018,
2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine manufacturers
- Product
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine 1152475-50-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine 1152475-50-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-03