ChemicalBook > CAS DataBase List > 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine

1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine

Product Name
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine
CAS No.
132834-56-1
Chemical Name
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine
Synonyms
Org 12962,Org12962;1-(6-Chloro-5-(trifluoromethyl);1-[6-Chloro-5-(trifluoromethyl)-2-pyridyl]piperazine;1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine;Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-
CBNumber
CB72473320
Molecular Formula
C10H11ClF3N3
Formula Weight
265.66
MOL File
132834-56-1.mol
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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine Property

Melting point:
76～78℃
Boiling point:
387.1±42.0 °C(Predicted)
Density 
1.352±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO: 250 mg/mL (941.05 mM)
form 
Solid
pka
8.38±0.10(Predicted)
color 
White to light yellow
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0065306
Product name
Org-12962
Purity
>98.0%
Packaging
5mg
Price
$50
Updated
2021/12/16
AK Scientific
Product number
6011AA
Product name
1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine
Packaging
250mg
Price
$223
Updated
2021/12/16
Apolloscientific
Product number
PC200280
Product name
1-[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine
Packaging
1g
Price
$250
Updated
2021/12/16
Apolloscientific
Product number
PC200280
Product name
1-[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine
Packaging
500mg
Price
$270
Updated
2021/12/16
Matrix Scientific
Product number
048597
Product name
1-[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]-piperazine
Purity
>95%
Packaging
500mg
Price
$362
Updated
2021/12/16
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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine Chemical Properties,Usage,Production

Uses

Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].

in vivo

Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%)[1].

Animal Model:Male Wistar rats[2]
Dosage:0.3 mg/kg, 1 mg/kg, 3.2 mg/kg
Administration:Intraperitoneal injection; 0.3-3.2 mg/kg
Result:Induced a dose-related antipanic-like effect in rat.

IC 50

5-HT2C Receptor: 7.01 (pEC50); 5-HT2A Receptor: 6.38 (pEC50); 5-HT2B Receptor: 6.28 (pEC50)

References

[1] Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. DOI:10.1038/sj.bjp.0702751
[2] Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. DOI:10.1016/s0924-977x(97)00055-2
[3] Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22. DOI:10.1016/s0378-5173(03)00372-7

1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine Suppliers

China 30 France 1 Germany 1 India 1 United Kingdom 1 United States 9 Global 43
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132834-56-1, 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazineRelated Search:

Trifluoromethanesulfonyl chloride TRIFLUOROMETHYLSULPHENYL CHLORIDE

  • 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine
  • 1-(6-Chloro-5-(trifluoromethyl)
  • Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-
  • Org 12962,Org12962
  • 1-[6-Chloro-5-(trifluoromethyl)-2-pyridyl]piperazine
  • 132834-56-1