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AZD1152

Product Name
AZD1152
CAS No.
722543-31-9
Chemical Name
AZD1152
Synonyms
AZD1152;CS-1053;Barasertib (AZD1152);Barasertib, 10 mM in DMSO;BARASERTIB; AZD-1152; AZD 1152;5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide;1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-;2-(Ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate;2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl dihydrogen phosphate
CBNumber
CB72476033
Molecular Formula
C26H31FN7O6P
Formula Weight
587.54
MOL File
722543-31-9.mol
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AZD1152 Property

Density 
1.463
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
insoluble in H2O; insoluble in EtOH; ≥5.88 mg/mL in DMSO
form 
solid
pka
1.75±0.10(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13647
Product name
AZD 1152
Purity
≥95%
Packaging
1mg
Price
$65
Updated
2021/12/16
Cayman Chemical
Product number
13647
Product name
AZD 1152
Purity
≥95%
Packaging
5mg
Price
$293
Updated
2021/12/16
Cayman Chemical
Product number
13647
Product name
AZD 1152
Purity
≥95%
Packaging
10mg
Price
$488
Updated
2021/12/16
Cayman Chemical
Product number
13647
Product name
AZD 1152
Purity
≥95%
Packaging
25mg
Price
$975
Updated
2021/12/16
TRC
Product number
B129135
Product name
Barasertib
Packaging
5mg
Price
$205
Updated
2021/12/16
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AZD1152 Chemical Properties,Usage,Production

Uses

Barasertib. is a selective inhibitor of Aurora B kinase, which inhibits human tumor xenograft growth by inducing apoptosis.

Definition

ChEBI: AZT-1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma. It has a role as a prodrug, an antineoplastic agent and an Aurora kinase inhibitor. It is a member of quinazolines, a monoalkyl phosphate, an anilide, a member of monofluorobenzenes, a member of pyrazoles, a secondary amino compound, a secondary carboxamide and a tertiary amino compound. It is functionally related to an AZD-1152.

in vivo

Barasertib (AZD1152, 25 mg/kg) markedly suppresses the growth and weights of AZD1152-treated tumors[1].
Barasertib (AZD1152, 5 mg/kg) enhances the ability of vincristine or daunorubicin to inhibit the proliferation of human MOLM13 leukemic xenografts[1].
Barasertib (AZD1152, (10-150 mg/kg/d) potently inhibited the growth of human colon, lung, and hematologic tumor xenografts (mean tumor growth inhibition range, 55% to z100%; P < 0.05) in immunodeficient mice[2].

Animal Model:Female immune-deficient BALB/c nude mice (MOLM13 cells injected)[1].
Dosage:5 or 25 mg/kg.
Administration:Intraperitoneal injection 4 times a week or every another day.
Result:Inhibited the growth of human MOLM13 cells growing as xenografts using an immunodeficient murine model.

IC 50

Aurora B: 0.37 nM (IC50)

AZD1152 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD1152 Suppliers

China 104 United States 14 Global 118
Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
Country
United States
ProdList
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65
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097 15801866362;
Email
info@topbiochem.com
Country
China
ProdList
9520
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58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
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China
ProdList
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
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info@adooq.com
Country
United States
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2782
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Bide Pharmatech Ltd.
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400-400-164-7117 18317119277
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+86-21-61629029
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product02@bidepharm.com
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China
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40000
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
Fax
025-68650336
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info@adooq.cn
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China
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2990
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Shanghai XingMo Biotechnology Co., Ltd.
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+86 13524779951; 13524779951
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QQ: 2075692521
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2075692521@qq.com
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  • 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
  • AZD1152
  • 5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide
  • BARASERTIB; AZD-1152; AZD 1152
  • Barasertib (AZD1152)
  • CS-1053
  • 2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl dihydrogen phosphate
  • 2-(Ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate
  • Barasertib, 10 mM in DMSO
  • 722543-31-9