2,4-Dichloro-5-(iodomethyl)pyrimidine

Product Name: 2,4-Dichloro-5-(iodomethyl)pyrimidine
CAS No.: 7627-44-3
Chemical Name: 2,4-Dichloro-5-(iodomethyl)pyrimidine
Synonyms: 2,4-Dichloro-5-(iodomethyl);2,4-Dichloro-5-(iodomethyl)pyrimidine;Pyrimidine, 2,4-dichloro-5-(iodomethyl)-;2,4-Dichloro-5-(iodomethyl)pyrimidine 95%
CBNumber: CB72482391
Molecular Formula: C5H3Cl2IN2
Formula Weight: 288.9
MOL File: 7627-44-3.mol

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2,4-Dichloro-5-(iodomethyl)pyrimidine Property

Melting point:: 78-79°
Boiling point:: 327.4±32.0 °C(Predicted)
Density: 2.141±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Solid
pka: -3.39±0.29(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C5H3Cl2IN2/c6-4-3(1-8)2-9-5(7)10-4/h2H,1H2
InChIKey: NEIMQFSSWKAYTR-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(CI)C(Cl)=N1

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Safety

HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H272May intensify fire; oxidizer

H314Causes severe skin burns and eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P221Take any precaution to avoid mixing with combustibles/…

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P331Do NOT induce vomiting.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: C384245
Product name: ChloromethylPropylEther
Packaging: 50mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD145166
Product name: 2,4-Dichloro-5-(iodomethyl)pyrimidine
Packaging: 250mg
Price: $170
Updated: 2021/12/16

Apolloscientific

Product number: OR18550
Product name: 2,4-Dichloro-5-(iodomethyl)pyrimidine
Purity: 95%
Packaging: 500mg
Price: $182
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-M-17
Product name: 2,4-Dichloro-5-(iodomethyl)pyrimidine
Packaging: 500mg
Price: $200
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-M-17
Product name: 2,4-Dichloro-5-(iodomethyl)pyrimidine
Packaging: 5G
Price: $1114
Updated: 2021/12/16

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2,4-Dichloro-5-(iodomethyl)pyrimidine Chemical Properties,Usage,Production

Synthesis

7627-38-5

7627-44-3

General procedure for the synthesis of 2,4-dichloro-5-(chloromethyl)pyrimidine from 2,4-dichloro-5-(iodomethyl)pyrimidine: A mixture of 2,4-dichloro-5-(chloromethyl)pyrimidine (15.0 g, 76.0 mmol) and sodium iodide (13.7 g, 91.4 mmol) in acetone was stirred for 45 min at 60 °C. After completion of the reaction, the resulting sodium chloride precipitate was removed by filtration and the precipitate was washed with acetone. The filtrates were combined and concentrated under reduced pressure to give a light yellow solid crude product. The crude product was purified by silica gel column chromatography using dichloromethane as eluent to afford 2,4-dichloro-5-(iodomethyl)pyrimidine as a light yellow solid (30.8 g, 96% yield).LC-MS (m/z): 289.3 [M + H]+.

References

[1] Patent: WO2007/136465, 2007, A2. Location in patent: Page/Page column 43-44
[2] Patent: WO2018/53373, 2018, A1. Location in patent: Paragraph 00485; 00486
[3] Patent: WO2018/160774, 2018, A1. Location in patent: Paragraph 00377; 00378
[4] Patent: WO2018/25043, 2018, A1. Location in patent: Page/Page column 24
[5] Patent: US2016/75720, 2016, A1. Location in patent: Paragraph 0323

2,4-Dichloro-5-(iodomethyl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-5-(iodomethyl)pyrimidine Suppliers

China 43 India 1 United Kingdom 2 United States 5 Global 51

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7627-44-3, 2,4-Dichloro-5-(iodomethyl)pyrimidineRelated Search:

2,4-Dichloro-5-(iodomethyl)

2,4-Dichloro-5-(iodomethyl)pyrimidine

2,4-Dichloro-5-(iodomethyl)pyrimidine 95%

Pyrimidine, 2,4-dichloro-5-(iodomethyl)-

7627-44-3