Difluoromethyl phenyl sulfone

Product Name: Difluoromethyl phenyl sulfone
CAS No.: 1535-65-5
Chemical Name: Difluoromethyl phenyl sulfone
Synonyms: PhSO2CF2H;[(Difluoromethyl)sulfonyl]benzene;Difluoromethyl phenyl sul;Phenyl difluoromethyl sulfone;Difluoromethyl phenyl sulfone;Difluoromethylphenylsulfone,95%;1-(difluoroMethylsulfonyl)benzene;Difluoromethyl Phenyl Sulfone >Difluoromethyl phenyl sulfone >=97%;Benzene, [(difluoroMethyl)sulfonyl]-
CBNumber: CB72485024
Molecular Formula: C7H6F2O2S
Formula Weight: 192.18
MOL File: 1535-65-5.mol

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Difluoromethyl phenyl sulfone Property

Melting point:: 24-25℃
Boiling point:: 115-120 °C(Press: 7 Torr)
Density: 1.348
refractive index: 1.5000
Flash point:: 128℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: liquid
color: colorless
Water Solubility: Soluble in chloroform and water.
BRN: 2259218

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26-24/25
WGK Germany: 3
TSCA: No
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 742600
Product name: Difluoromethyl phenyl sulfone
Purity: ≥97%
Packaging: 1g
Price: $82.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 742600
Product name: Difluoromethyl phenyl sulfone
Purity: ≥97%
Packaging: 10g
Price: $478
Updated: 2024/03/01

TCI Chemical

Product number: D4764
Product name: Difluoromethyl Phenyl Sulfone
Purity: >98.0%(GC)
Packaging: 1g
Price: $71
Updated: 2024/03/01

TCI Chemical

Product number: D4764
Product name: Difluoromethyl Phenyl Sulfone
Purity: >98.0%(GC)
Packaging: 5g
Price: $248
Updated: 2024/03/01

Alfa Aesar

Product number: H64760
Product name: Difluoromethyl phenyl sulfone, 95%
Packaging: 1g
Price: $65.65
Updated: 2024/03/01

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Difluoromethyl phenyl sulfone Chemical Properties,Usage,Production

Description

Difluoromethyl phenyl sulfone is a powerful nucleophilic difluoromethylation reagent due to the high reactivity of the sulfonyl-stabilized difluoromethyl anion towards many electrophiles including carbonyls, imines, alkyl halides, and cyclic sulfates and sulfamidates. In the nucleophilic reaction step, depending on the substrate structure, strong bases are used to generate the nucleophilic (phenylsulfonyl)difluoromethyl anion in situ. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the (phenylsulfonyl)difluoromethylated compounds can undergo β-elimination to afford gem-difluoroalkenes.

Chemical Properties

light yellow liquid

Uses

Efficient reagent for difluoromethylation of carbonyls and aldehydes.

Uses

Difluoromethyl Phenyl Sulfone has been used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls

Reactions

(1) Difluoromethylation of alkyl halides.

(2) Difluoromethylation of aldehydes and ketones.

(3) Difluoromethylenation of aldimines and ketimines.

(4) Difluoromethylation of cyclic sulfates and sulfamidates.

(5) (Phenylsulfonyl)difluoromethylation of carboxylic acid esters.

(6) Difluoromethylenation of alkyl halides.

(7) Difluoromethylenation of aromatic aldehydes.

References

[1] G. PRAKASH. Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent.[J]. Organic Letters, 2004. DOI:10.1002/CHIN.200509059.
[2] G. K. SURYA PRAKASH. Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1-Difluoro-1-alkenes.[J]. ChemInform, 2005. DOI:10.1002/chin.200504098.
[3] G. K. SURYA PRAKASH. Nucleophilic Difluoromethylation of Primary Alkyl Halides Using Difluoromethyl Phenyl Sulfone as a Difluoromethyl Anion Equivalent[J]. Organic Letters, 2004, 6 23: 4315-4317. DOI:10.1021/ol048166i.

Difluoromethyl phenyl sulfone Preparation Products And Raw materials

Raw materials

Preparation Products

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Difluoromethyl phenyl sulfone Suppliers

Americas 1 China 120 Europe 1 Germany 1 India 3 Japan 1 Switzerland 1 United Kingdom 1 United States 12 Global 141

Accela ChemBio Inc.

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Matrix Scientific

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View Lastest Price from Difluoromethyl phenyl sulfone manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Difluoromethyl phenyl sulfone 1535-65-5
Price: US $0.10/kg
Min. Order: 0.005kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-15

Career Henan Chemical Co

Product: [(Difluoromethyl)sulfonyl]benzene 1535-65-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-24

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