Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate
- Product Name
- Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate
- CAS No.
- 1188477-11-3
- Chemical Name
- Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate
- Synonyms
- Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate;tert-butyl N-[(5-bromo-2-pyridyl)methyl]carbamate;Carbamic acid, N-[(5-bromo-2-pyridinyl)methyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB72499212
- Molecular Formula
- C11H15BrN2O2
- Formula Weight
- 287.15
- MOL File
- 1188477-11-3.mol
Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate Property
- Boiling point:
- 372.4±32.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.14±0.46(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B129575
- Product name
- tert-Butyl((5-Bromopyridin-2-yl)methyl)carbamate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- AS29036
- Product name
- 2-(Boc-aminomethyl)-5-bromopyridine
- Purity
- 97+%
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- AS29036
- Product name
- 2-(Boc-aminomethyl)-5-bromopyridine
- Purity
- 97+%
- Packaging
- 1g
- Price
- $259
- Updated
- 2021/12/16
- Product number
- 073840
- Product name
- (5-Bromopyridin-2-ylmethyl)carbamic acidtert-butyl ester
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $416
- Updated
- 2021/12/16
- Product number
- X9325
- Product name
- (5-Bromopyridin-2-ylmethyl)carbamicacidtert-butylester
- Packaging
- 5g
- Price
- $531
- Updated
- 2021/12/16
Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate Chemical Properties,Usage,Production
Synthesis
24424-99-5
97483-77-7
1188477-11-3
GENERAL STEPS: To a solution of 5-bromo-2-cyanopyridine (3.0 g, 16.4 mmol) in methanol (60 mL) was sequentially added di-tert-butyl dicarbonate (7.2 g, 32.8 mmol) and nickel chloride hexahydrate (0.33 g, 1.64 mmol). The reaction mixture was cooled to 0 °C, followed by the addition of sodium borohydride (4.3 g, 0.115 mol) in batches over a period of 2 hours. The reaction mixture was continued to be stirred at 15 °C for 1 h, after which it was poured into ice water (200 g) and extracted with ethyl acetate. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by fast column chromatography to afford the target product tert-butyl (5-bromopyridin-2-ylmethyl)carbamate (2.2 g, 47% yield) as a yellow solid. m/z 287,289 ([M+H]+) by LC-MS.
References
[1] Patent: WO2016/112088, 2016, A1. Location in patent: Paragraph 0660
[2] Patent: US2013/237502, 2013, A1. Location in patent: Paragraph 0367
[3] Patent: WO2018/42342, 2018, A1. Location in patent: Page/Page column 53
Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate Suppliers
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- Fax
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- sales@ajchem.in
- Country
- India
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View Lastest Price from Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate manufacturers
- Product
- Tert-Butyl5-Bromopyridin-2-yl(methyl)carbamate 1188477-11-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02