DL-METHIONINE METHYLSULFONIUM CHLORIDE
- Product Name
- DL-METHIONINE METHYLSULFONIUM CHLORIDE
- CAS No.
- 1115-84-0
- Chemical Name
- DL-METHIONINE METHYLSULFONIUM CHLORIDE
- Synonyms
- MMSC;u-vit;yucron;C04078;cabagin;ardesyl;Vitas U;merastom;epadyn-u;cabaginu
- CBNumber
- CB7249996
- Molecular Formula
- C6H14ClNO2S
- Formula Weight
- 199.7
- MOL File
- 1115-84-0.mol
DL-METHIONINE METHYLSULFONIUM CHLORIDE Property
- Melting point:
- 134 °C (decomp)
- FEMA
- 3445 | DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE
- storage temp.
- Hygroscopic, Refrigerator, Under inert atmosphere
- solubility
- Water (Soluble), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Odor
- at 100.00 %. malty tomato potato sulfury green
- Odor Type
- malty
- JECFA Number
- 1427
- Stability:
- Hygroscopic
- LogP
- 0.28
- CAS DataBase Reference
- 1115-84-0(CAS DataBase Reference)
Safety
- Toxicity
- LD50 oral in rat: > 6gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M260470
- Product name
- L-Methionine-S-methylSulfoniumChloride
- Packaging
- 500mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 282085
- Product name
- L-Methionine-S-methyl sulfonium chloride
- Packaging
- 500mg
- Price
- $468
- Updated
- 2021/12/16
- Product number
- 52118
- Product name
- L-Methionine-S-methylSulfoniumChloride
- Packaging
- 1g
- Price
- $650
- Updated
- 2021/12/16
- Product number
- VIT0000805
- Product name
- METHYLMETHIONINE SULFONIUM CHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $329.7
- Updated
- 2021/12/16
DL-METHIONINE METHYLSULFONIUM CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Naturally occurs as the L-form in a variety of vegetables. Although used in food as a flavoring ingredient in fish products, it has also been used therapeutically in the treatment of peptic ulcers, colitis and gastritis.
Originator
Cabagin-U,Kowa
Occurrence
Reported found in asparagus, cabbage, cabbage juice, celery, sweet corn, milk, potato, tea, green tea and tomato.
Uses
A derivative of L-Methionine (M260440). Naturally occurring sulfonium compound found in a large number of plants. Identification of antiulcer vitamin in cabbage leaves. Antiulcerative.
Definition
ChEBI: Methylmethionine sulfonium salt is an organic molecular entity.
Application
Methiosulfonium chloride is used for its protective effect on the liver and gastrointestinal mucosa, whereas the iodide finds use for rheumatic disorders.
Manufacturing Process
298 g dl-methionine, 2000 ml water and 151.1 methyl chloride were put into autoclave (volume 3 L) made from V4-a steel. The mixture was heated at temperature 50°-55°C for 8 hours and pressure 12-13 atmospheres.
On cooling an excess of methyl chloride was evaporated, the slightly yellow residue was mixed with 0.2% activated coal and filtered. Water was evaporated in vacuum at 45°-55°C. 2 L methanol was poured into an almost colorless syrup obtained, cooled to -5°-(-10°)C. The methylmethioninesulfonium chloride crystallized.
It was filtered off to give 340 g (85.3%) of desired product 99.5 % purity (data of thin-layer chromatography).
Therapeutic Function
Hepatoprotectant
Taste threshold values
Taste characteristics at 5 ppm: sulfureous creamy, tomato, malty, vegetable like
Trade name
Chloride: Ardesyl (Beytout, France), withdrawn from the market; Cabagin (Kowa, Japan). Iodide: Lobarthrose (Opodex, France), withdrawn from the market.
Purification Methods
Likely impurities are methionine, methionine sulfoxide and methionine sulfone. Crystallise Vitamin U from water by adding a large excess of EtOH. It is hygroscopic. It should be stored in a cool, dry place and protected from light. It has also been purified on a column of Dowex 50 H+ form, washed with H2O and eluted with 6N ammonia, lyophilised, the residue is dissolved in dilute HCl, lyophilised again and then it is obtained as colourless prisms by vapour diffusion of Et2O in a 1:1 (v/v) mixture of MeOH/EtOH in which the hydrochloride is dissolved [Del Re Acta Cryst B 33 3289 1977]. The iodide salt, m ~ 150o(dec), is obtained by dissolving it in 50% aqueous EtOH and adding ~3.5 volumes of absolute EtOH. The bromide salt has m 140o(dec) [Toennies & Kolb J Amer Chem Soc 67 849 1945].
DL-METHIONINE METHYLSULFONIUM CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DL-METHIONINE METHYLSULFONIUM CHLORIDE manufacturers
- Product
- Methyl Methanesulfonate 1115-84-0
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-18
- Product
- L-Methionine-S-Methyl SulfoniuM Chloride 1115-84-0
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2020-01-08