ChemicalBook > CAS DataBase List > DL-METHIONINE METHYLSULFONIUM CHLORIDE

DL-METHIONINE METHYLSULFONIUM CHLORIDE

Product Name
DL-METHIONINE METHYLSULFONIUM CHLORIDE
CAS No.
1115-84-0
Chemical Name
DL-METHIONINE METHYLSULFONIUM CHLORIDE
Synonyms
MMSC;u-vit;yucron;C04078;cabagin;ardesyl;Vitas U;merastom;epadyn-u;cabaginu
CBNumber
CB7249996
Molecular Formula
C6H14ClNO2S
Formula Weight
199.7
MOL File
1115-84-0.mol
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DL-METHIONINE METHYLSULFONIUM CHLORIDE Property

Melting point:
134 °C (decomp)
FEMA 
3445 | DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE
storage temp. 
Hygroscopic, Refrigerator, Under inert atmosphere
solubility 
Water (Soluble), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Odor
at 100.00 %. malty tomato potato sulfury green
Odor Type
malty
JECFA Number
1427
Stability:
Hygroscopic
LogP
0.28
CAS DataBase Reference
1115-84-0(CAS DataBase Reference)
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Safety

Toxicity
LD50 oral in rat: > 6gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
M260470
Product name
L-Methionine-S-methylSulfoniumChloride
Packaging
500mg
Price
$135
Updated
2021/12/16
Usbiological
Product number
282085
Product name
L-Methionine-S-methyl sulfonium chloride
Packaging
500mg
Price
$468
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
52118
Product name
L-Methionine-S-methylSulfoniumChloride
Packaging
1g
Price
$650
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
VIT0000805
Product name
METHYLMETHIONINE SULFONIUM CHLORIDE
Purity
95.00%
Packaging
1G
Price
$329.7
Updated
2021/12/16
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DL-METHIONINE METHYLSULFONIUM CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Naturally occurs as the L-form in a variety of vegetables. Although used in food as a flavoring ingredient in fish products, it has also been used therapeutically in the treatment of peptic ulcers, colitis and gastritis.

Originator

Cabagin-U,Kowa

Occurrence

Reported found in asparagus, cabbage, cabbage juice, celery, sweet corn, milk, potato, tea, green tea and tomato.

Uses

A derivative of L-Methionine (M260440). Naturally occurring sulfonium compound found in a large number of plants. Identification of antiulcer vitamin in cabbage leaves. Antiulcerative.

Definition

ChEBI: Methylmethionine sulfonium salt is an organic molecular entity.

Application

Methiosulfonium chloride is used for its protective effect on the liver and gastrointestinal mucosa, whereas the iodide finds use for rheumatic disorders.

Manufacturing Process

298 g dl-methionine, 2000 ml water and 151.1 methyl chloride were put into autoclave (volume 3 L) made from V4-a steel. The mixture was heated at temperature 50°-55°C for 8 hours and pressure 12-13 atmospheres.
On cooling an excess of methyl chloride was evaporated, the slightly yellow residue was mixed with 0.2% activated coal and filtered. Water was evaporated in vacuum at 45°-55°C. 2 L methanol was poured into an almost colorless syrup obtained, cooled to -5°-(-10°)C. The methylmethioninesulfonium chloride crystallized.
It was filtered off to give 340 g (85.3%) of desired product 99.5 % purity (data of thin-layer chromatography).

Therapeutic Function

Hepatoprotectant

Taste threshold values

Taste characteristics at 5 ppm: sulfureous creamy, tomato, malty, vegetable like

Trade name

Chloride: Ardesyl (Beytout, France), withdrawn from the market; Cabagin (Kowa, Japan). Iodide: Lobarthrose (Opodex, France), withdrawn from the market.

Purification Methods

Likely impurities are methionine, methionine sulfoxide and methionine sulfone. Crystallise Vitamin U from water by adding a large excess of EtOH. It is hygroscopic. It should be stored in a cool, dry place and protected from light. It has also been purified on a column of Dowex 50 H+ form, washed with H2O and eluted with 6N ammonia, lyophilised, the residue is dissolved in dilute HCl, lyophilised again and then it is obtained as colourless prisms by vapour diffusion of Et2O in a 1:1 (v/v) mixture of MeOH/EtOH in which the hydrochloride is dissolved [Del Re Acta Cryst B 33 3289 1977]. The iodide salt, m ~ 150o(dec), is obtained by dissolving it in 50% aqueous EtOH and adding ~3.5 volumes of absolute EtOH. The bromide salt has m 140o(dec) [Toennies & Kolb J Amer Chem Soc 67 849 1945].

DL-METHIONINE METHYLSULFONIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DL-METHIONINE METHYLSULFONIUM CHLORIDE Suppliers

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View Lastest Price from DL-METHIONINE METHYLSULFONIUM CHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
L-Methionine-S-Methyl SulfoniuM Chloride 1115-84-0
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2020-01-08
Hebei Zhanyao Biotechnology Co. Ltd
Product
Methyl Methanesulfonate 1115-84-0
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-18

1115-84-0, DL-METHIONINE METHYLSULFONIUM CHLORIDERelated Search:

Dimethyl sulfoxide Trifluoromethanesulfonic acid Sodium bisulfate monohydrate Sulfuryl chloride Sodium acrylate Sodium silicate Sulfamic acid Isopropyl alcohol L-Methionine DL-METHIONINE METHYLSULFONIUM CHLORIDE DL-METHIONINE METHYLSULFONIUM CHLORIDE DL-METHIONINE METHYLSULFONIUM CHLORIDE L-METHIONINE-D3 (S-METHYL-D3)-METHYL-D3 SULFONIUM CHLORIDE L-METHIONINE HYDROCHLORIDE SOLUTION S-ADENOSYL-L-METHIONINE CHLORIDE SALT DL-METHIONINE HYDROCHLORIDE BOC-DL-METHIONINE METHYLSULFONIUM CHLORIDE FMOC-DL-METHIONINE METHYLSULFONIUM CHLORIDE

  • (3-amino-3-carboxypropyl)dimethyl-,chloride,(s)-sulfoniu
  • (3-amino-3-carboxypropyl)dimethyl-,chloride,l-sulfoniu
  • (3-amino-3-carboxypropyl)dimethyl-,chloride,L-Sulfonium
  • VITAMIN U
  • VITAMIN U CHLORIDE
  • ardesyl
  • cabagin
  • cabaginu
  • epadyn-u
  • merastom
  • methylmethioninesulfoniumchloride
  • s-methymethioninechloride
  • u-vit
  • yucron
  • S-methylmethioninium chloride
  • (S)-(3-Amino-3-carboxypropyl)dimethyl sulfonium chloride
  • L-MethionineS-methylsulfoniumchloride
  • Methylmethionine
  • Sulfonium, (3S)-3-amino-3-carboxypropyldimethyl-, chloride
  • METHIOSULFONIUMCHLORIDE
  • S-METHYLMETHIONINESULFONIUM CHLORIDE
  • S-METHYL-DL-METHIONINE-SULFONIUMCHLORIDE
  • (3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE
  • DL-METHIONINE METHYLSULFONIUM CHLORIDE
  • DL-METHYLMETHIONINE SULFONIUMCHLORIDE
  • DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE
  • METHYL-METHIONINE SULPHONIUM CHLORIDE
  • DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULPHONIUMCHLORIDE
  • Vitamin U,chlorine type
  • L-Methionine methylsulfonium chloride
  • VITAMIN U (USP) (S-METHYLMETHIONINESULFONIUM CHLORIDE)
  • [(3S)-3-AMino-3-carboxypropyl](diMethyl)sulfoniuM Chloride
  • L-(3-AMino-3-carboxypropyl)(diMethyl)sulfoniuM Chloride
  • MMSC
  • S-MethylMethionine Chloride
  • Vitas U
  • [(3S)-3-amino-3-carboxypropyl]-dimethylsulfanium:chloride
  • L-Methylmethionine sulfonium chloride
  • Methionine methylsulfonium chloride
  • C04078
  • Methylmethionine sulfonium salt
  • Pardoprunox Impurity 26
  • Decarboxylated (S)-Adenosyl Methionine Tritrifluoromethanesulfonic Acid
  • 1115-84-0
  • 115-84-0
  • C6H14NO2SCl
  • C6H16ClNO2S
  • Modified Amino Acids
  • I - Z
  • Sulfonium Compounds
  • Iodonium Sulfonium & Oxonium Compounds
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Vitamins and derivatives
  • Amino Acids & Derivatives
  • Sulfur & Selenium Compounds