5-Dehydro Tolvaptan
- Product Name
- 5-Dehydro Tolvaptan
- CAS No.
- 137973-76-3
- Chemical Name
- 5-Dehydro Tolvaptan
- Synonyms
- Dehydrotolvaptan;5-Dehydro Tolvaptan;Tolvaptan Intermediate;Tolvaptan 5-Oxo Analog;Tolvaptan impurity 5 (DM-21826);7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-ox...;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methy;N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbe;7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
- CBNumber
- CB72500620
- Molecular Formula
- C26H23ClN2O3
- Formula Weight
- 446.93
- MOL File
- 137973-76-3.mol
5-Dehydro Tolvaptan Property
- Melting point:
- >118°C (dec.)
- Boiling point:
- 593.2±50.0 °C(Predicted)
- Density
- 1.307
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.97±0.70(Predicted)
- color
- White to Off-White
- InChIKey
- VENGMROMZOKURN-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(=O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D230350
- Product name
- 5-DehydroTolvaptan
- Packaging
- 50mg
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- FC151485
- Product name
- N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
- Packaging
- 2mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FC151485
- Product name
- N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
- Packaging
- 5mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- Z3698
- Product name
- 5-DehydroTolvaptan
- Packaging
- 1g
- Price
- $174
- Updated
- 2021/12/16
- Product number
- FC151485
- Product name
- N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
- Packaging
- 10mg
- Price
- $203
- Updated
- 2021/12/16
5-Dehydro Tolvaptan Chemical Properties,Usage,Production
Uses
5-Dehydro Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH g
Preparation
To a 3 L reactor was added 1- (4-amino-2-methylbenzoyl) -7-chloro-5-oxo-2,3,4,5-tetrahydro- 1 H- 1 -benzazepine (70. 0 g, 212.90 mmol), dichloromethane (560 ml) and distilled water (140 ml), and the mixture was stirred for 1 hour. Magnesium hydroxide (14.90 g, 14.90 mmol) was added to the reaction mixture at 10 ° C. or lower, and the mixture was stirred for 30 minutes. 2-Methylbenzoyl chloride (30.42 ml) was gradually added to the reaction mixture, stirring for 3 hours. The reaction mixture was filtered to remove magnesium hydroxide, and the pH of the reaction mixture was adjusted to pH 8 to 9 using an aqueous sodium hydroxide solution, and then the organic layer was separated. The obtained organic layer was dried with sodium sulfate (Na 2 SO 4), filtered, and concentrated under reduced pressure to give 5-Dehydro Tolvaptan (yield: 96 percent).
5-Dehydro Tolvaptan Preparation Products And Raw materials
Raw materials
Preparation Products
5-Dehydro Tolvaptan Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from 5-Dehydro Tolvaptan manufacturers
- Product
- Tolvaptan Impurity 4 137973-76-3
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-08-12
- Product
- Tolvaptan Intermediate 137973-76-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 5 tons
- Release date
- 2019-08-04
- Product
- N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide 137973-76-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Ask
- Release date
- 2018-12-19