3-Bromo-5-fluoro-2-methylaniline

Product Name: 3-Bromo-5-fluoro-2-methylaniline
CAS No.: 502496-36-8
Chemical Name: 3-Bromo-5-fluoro-2-methylaniline
Synonyms: 2-Methyl-3-bromo-5-fluoroaniline;3-Bromo-5-fluoro-2-methylaniline;2-Amino-6-bromo-4-fluorotoluene 98%;3-Bromo-5-fluoro-2-methylphenylamine;3-Bromo-5-fluoro-2-methylbenzenamine;BenzenaMine, 3-broMo-5-fluoro-2-Methyl-;3-Bromo-5-fluoro-2-methylaniline ISO 9001：2015 REACH
CBNumber: CB72500781
Molecular Formula: C7H7BrFN
Formula Weight: 204.04
MOL File: 502496-36-8.mol

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3-Bromo-5-fluoro-2-methylaniline Property

Boiling point:: 259℃
Density: 1.589
Flash point:: 110℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 2.36±0.10(Predicted)
form: powder
color: Light orange to light brown
InChI: InChI=1S/C7H7BrFN/c1-4-6(8)2-5(9)3-7(4)10/h2-3H,10H2,1H3
InChIKey: DSYSVUWIAUMZDQ-UHFFFAOYSA-N
SMILES: C1(N)=CC(F)=CC(Br)=C1C

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Safety

HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B700330
Product name: 3-Bromo-5-fluoro-2-methylaniline
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3730-B-09
Product name: 2-Amino-6-bromo-4-fluorotoluene
Packaging: 1g
Price: $184
Updated: 2021/12/16

AK Scientific

Product number: Z4802
Product name: 3-Bromo-5-fluoro-2-methylaniline
Packaging: 5g
Price: $272
Updated: 2021/12/16

Matrix Scientific

Product number: 089936
Product name: 3-Bromo-5-fluoro-2-methylaniline
Purity: 95+%
Packaging: 5g
Price: $363
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3730-B-09
Product name: 2-Amino-6-bromo-4-fluorotoluene
Packaging: 5G
Price: $384
Updated: 2021/12/16

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3-Bromo-5-fluoro-2-methylaniline Chemical Properties,Usage,Production

Synthesis

502496-33-5

502496-36-8

General procedure for the synthesis of 2-methyl-3-bromo-5-fluoroaniline from 2-bromo-4-fluoro-6-nitrotoluene: [00402] Ammonium chloride (571 mg, 10.7 mmol) was added to a mixture of 1-bromo-5-fluoro-2-methyl-3-nitrobenzene (500 mg, 2.14 mmol) and iron powder (0.6 g, 10.68 mmol). Water (24 mL) and ethanol (24 mL) were subsequently added. The reaction mixture was refluxed for 5 h. After completion of the reaction, it was filtered through diatomaceous earth and the filter cake was washed with ethanol (100 mL) and ethyl acetate (100 mL). The organic solvent was removed in vacuum to give an aqueous solution, which was extracted with dichloromethane (3 x 30 mL). The organic layer was separated and concentrated to afford the crude product 3-bromo-5-fluoro-2-methylaniline (390 mg, 1.87 mmol, 87.7% yield), which was analyzed by nuclear magnetic resonance (NMR) and showed good purity and could be used in the next reaction without further purification. [00403] 1H NMR (DMSO-d6): δ 6.60 (dd, J = 2.8 and 8.4 Hz, 1H), 6.42 (dd, J = 2.8 and 11.6 Hz, 1H), 5.54 (bs, 2H), 2.09 (s, 3H).

References

[1] Organic Letters, 2017, vol. 19, # 24, p. 6518 - 6521
[2] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[3] Patent: WO2015/79251, 2015, A1. Location in patent: Paragraph 00402; 00403
[4] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 155
[5] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0279; 0280

3-Bromo-5-fluoro-2-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-5-fluoro-2-methylaniline Suppliers

China 104 India 2 United Kingdom 2 United States 8 Global 116

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View Lastest Price from 3-Bromo-5-fluoro-2-methylaniline manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 3-Bromo-5-fluoro-2-methylaniline 502496-36-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞98% by HPLC
Supply Ability: 200kg/month
Release date: 2025-10-10

Career Henan Chemical Co

Product: 3-Bromo-5-fluoro-2-methylaniline 502496-36-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-12

502496-36-8, 3-Bromo-5-fluoro-2-methylanilineRelated Search:

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3-Bromo-5-fluoro-2-methylaniline

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3-Bromo-5-fluoro-2-methylaniline ISO 9001：2015 REACH

502496-36-8

Intermediate