COMU

ChemicalBook > CAS DataBase List > COMU

Product Name: COMU
CAS No.: 1075198-30-9
Chemical Name: COMU
Synonyms: {{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-4-morpholinomethylene}dimethylammonium;COMU(R) 97%;elagolix intermediate 13;COMU ISO 9001：2015 REACH;COMU NOVABIOCHEM(R) 25 G;(2-oxime cyanoacetate ethyl ester) - N, N-dimethylmorpholineurea hexafluorophosphate;[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium;(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate;4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate;4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate
CBNumber: CB72505584
Molecular Formula: C12H19F6N4O4P
Formula Weight: 428.2678402
MOL File: 1075198-30-9.mol

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COMU Property

Melting point:: ca 160℃
storage temp.: Store at -15°C to -25°C.
solubility: Soluble in DMF 1mmol in 2mL.
form: Powder or Solid
color: White to pale yellow
Sensitive: Air & Moisture Sensitive
InChI: InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
InChIKey: GPDHNZNLPKYHCN-DZOOLQPHSA-N
SMILES: C1N(/C(/O/N=C(\C(OCC)=O)/C#N)=[N+](\C)/C)CCOC1.[P-](F)(F)(F)(F)(F)F

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2934 99 90

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.51085
Product name: COMU?
Purity: 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminomorpholino)]uronium
Packaging: 25g
Price: $223
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.51085
Product name: COMU?
Purity: 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminomorpholino)]uronium
Packaging: 100g
Price: $667
Updated: 2024/03/01

Sigma-Aldrich

Product number: 712191
Product name: COMU?
Purity: 97%
Packaging: 5g
Price: $77.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 712191
Product name: COMU?
Purity: 97%
Packaging: 25g
Price: $279
Updated: 2024/03/01

Sigma-Aldrich

Product number: 712191
Product name: COMU?
Purity: 97%
Packaging: 100g
Price: $739
Updated: 2024/03/01

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COMU Chemical Properties,Usage,Production

Description

COMU is a third-generation uronium-type coupling reagent based on ethyl 2-cyano-2-(hydroxylamine)acetate (Oxyma) and a morpholino carbon skeleton. The presence of the morpholino group has a marked influence on the reagent's solubility, stability, and reactivity. COMU performed exceptionally well in the presence of only 1 equiv of base, confirming the effect of the hydrogen bond acceptor in the reaction. The by-products of COMU are water soluble and easily removed, making it an excellent choice of coupling reagent for solution-phase peptide synthesis[1].

Uses

(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate is used as a coupling reagent in the peptide synthesis. It is suitable for solution phase & solid phase peptide synthesis, visual or colorimetric reaction monitoring possible.

Uses

COMU – Safer and More Efficient Peptide Coupling Reagent

Advantages

Equal or even superior performance to HATU
Non-explosive (does not contain benzotriazole moiety)
Suitable for solution phase & solid phase peptide synthesis
Utmost retention of configuration – low to non-existent racemization
High solubility and stability in typical solvents
Visual or colorimetric reaction monitoring possible
Easy removal of water-soluble by-products

General Description

This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention".

References

[1] Ayman El-Faham,  Fernando Albericio. “COMU: A third generation of uronium-type coupling reagents.” Journal of Peptide Science 16 1 (2009): 6–9.

COMU Preparation Products And Raw materials

Raw materials

Preparation Products

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COMU Suppliers

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View Lastest Price from COMU manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: COMU 1075198-30-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-31

Henan Aochuang Chemical Co.,Ltd.

Product: COMU 1075198-30-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: COMU 1075198-30-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

1075198-30-9, COMURelated Search:

(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate

4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate

1-[1-(Cyano-2-ethoxy-2-oxoethylideneaMinooxy)-diMethylaMino-Morpholino]-uroniuM hexafluorophosphate

4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium(COMU?)

{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosp

(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium Hexafluorophosphate (This product is only available in Japan.)

COMU(R) 97%

elagolix intermediate 13

COMU 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium

4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate

{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-4-morpholinomethylene}dimethylammonium

COMU 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium,98%

COMU NOVABIOCHEM(R) 25 G

COMU ISO 9001：2015 REACH

4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium

[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium

[[(Z)-(1-Cyano-2-ethoxy-2-oxo-ethylidene)amino]oxy-morpholino-methylene]-dimethyl-ammonium hexafluorophosphate

[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium,hexafluorophosphate

4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate(V)

N-1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholin-4-yl)uronium hexafluorophosphate

(2-oxime cyanoacetate ethyl ester) - N, N-dimethylmorpholineurea hexafluorophosphate

1075198-30-9

C12H19N4O4PF6

C12H19F6N4O4P

C12H19N4O4F6P