COMU
- Product Name
- COMU
- CAS No.
- 1075198-30-9
- Chemical Name
- COMU
- Synonyms
- {{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-4-morpholinomethylene}dimethylammonium;COMU(R) 97%;elagolix intermediate 13;COMU ISO 9001：2015 REACH;COMU NOVABIOCHEM(R) 25 G;(2-oxime cyanoacetate ethyl ester) - N, N-dimethylmorpholineurea hexafluorophosphate;[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium;(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate;4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate;4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate
- CBNumber
- CB72505584
- Molecular Formula
- C12H19F6N4O4P
- Formula Weight
- 428.2678402
- MOL File
- 1075198-30-9.mol
COMU Property
- Melting point:
- ca 160℃
- storage temp.
- Store at -15°C to -25°C.
- solubility
- Soluble in DMF 1mmol in 2mL.
- form
- Powder or Solid
- color
- White to pale yellow
- Sensitive
- Air & Moisture Sensitive
- InChI
- InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
- InChIKey
- GPDHNZNLPKYHCN-DZOOLQPHSA-N
- SMILES
- C1N(/C(/O/N=C(\C(OCC)=O)/C#N)=[N+](\C)/C)CCOC1.[P-](F)(F)(F)(F)(F)F
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 8.51085
- Product name
- COMU?
- Purity
- 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminomorpholino)]uronium
- Packaging
- 25g
- Price
- $223
- Updated
- 2024/03/01
- Product number
- 8.51085
- Product name
- COMU?
- Purity
- 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminomorpholino)]uronium
- Packaging
- 100g
- Price
- $667
- Updated
- 2024/03/01
- Product number
- 712191
- Product name
- COMU?
- Purity
- 97%
- Packaging
- 5g
- Price
- $77.6
- Updated
- 2024/03/01
- Product number
- 712191
- Product name
- COMU?
- Purity
- 97%
- Packaging
- 25g
- Price
- $279
- Updated
- 2024/03/01
- Product number
- 712191
- Product name
- COMU?
- Purity
- 97%
- Packaging
- 100g
- Price
- $739
- Updated
- 2024/03/01
COMU Chemical Properties,Usage,Production
Description
COMU is a third-generation uronium-type coupling reagent based on ethyl 2-cyano-2-(hydroxylamine)acetate (Oxyma) and a morpholino carbon skeleton. The presence of the morpholino group has a marked influence on the reagent's solubility, stability, and reactivity. COMU performed exceptionally well in the presence of only 1 equiv of base, confirming the effect of the hydrogen bond acceptor in the reaction. The by-products of COMU are water soluble and easily removed, making it an excellent choice of coupling reagent for solution-phase peptide synthesis[1].
Uses
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate is used as a coupling reagent in the peptide synthesis. It is suitable for solution phase & solid phase peptide synthesis, visual or colorimetric reaction monitoring possible.
Uses
COMU – Safer and More Efficient Peptide Coupling Reagent
Advantages
- Equal or even superior performance to HATU
- Non-explosive (does not contain benzotriazole moiety)
- Suitable for solution phase & solid phase peptide synthesis
- Utmost retention of configuration – low to non-existent racemization
- High solubility and stability in typical solvents
- Visual or colorimetric reaction monitoring possible
- Easy removal of water-soluble by-products
General Description
This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention".
References
[1] Ayman El-Faham, Fernando Albericio. “COMU: A third generation of uronium-type coupling reagents.” Journal of Peptide Science 16 1 (2009): 6–9.
COMU Preparation Products And Raw materials
Raw materials
Preparation Products
COMU Suppliers
- Tel
- --
- Fax
- --
- ccc@merckgroup.com
- Country
- Germany
- ProdList
- 2010
- Advantage
- 58
View Lastest Price from COMU manufacturers
- Product
- COMU 1075198-30-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-31
- Product
- COMU 1075198-30-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-23
- Product
- COMU 1075198-30-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10