(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one

Product Name: (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one
CAS No.: 123367-26-0
Chemical Name: (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one
Synonyms: Imatinib impurity J;Irutinib Impurity A;(E)-3-(dimethylamino);Imatinib EP impuritiesA;Imatinib Mesilate Impurity A;Imatinib Mesilate EP Impurity A;Nilotinib Impurity 16 (Imatinib EP Impurity A);Imatinib EP Impurity A (Nilotinib Impurity 16);(E)-3-(Dimethylamino)-1-(3-pyridyl)-2-propen-1-one;(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one
CBNumber: CB72516261
Molecular Formula: C10H12N2O
Formula Weight: 176.22
MOL File: 123367-26-0.mol

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(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one Property

Melting point:: 113℃
Boiling point:: 281℃
Density: 1.070
Flash point:: 124℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 4.74±0.70(Predicted)
color: Dark Brown to Very Dark Brown
InChI: InChI=1S/C10H12N2O/c1-12(2)7-5-10(13)9-4-3-6-11-8-9/h3-8H,1-2H3/b7-5+
InChIKey: MZLRFUCMBQWLNV-FNORWQNLSA-N
SMILES: C(C1=CC=CN=C1)(=O)/C=C/N(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D462115
Product name: (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one
Packaging: 250mg
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-DW
Product name: (2E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
Purity: 98.0%
Packaging: 250mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-DW
Product name: (2E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
Purity: 98.0%
Packaging: 1g
Price: $95
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-DW
Product name: (2E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
Purity: 98.0%
Packaging: 5G
Price: $295
Updated: 2021/12/16

Alichem

Product number: 123367260
Product name: (E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
Packaging: 500g
Price: $296.8
Updated: 2021/12/16

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(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one Chemical Properties,Usage,Production

Description

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one is a pharmaceutical intermediate used as an intermediate of nilotinib, a targeted anticancer drug for the treatment of chronic myeloid leukaemia (CML).

Uses

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one acts as a reagent for the synthesis of oxindole-linked indolyl-pyrimidine derivatives which are potential cytotoxic agents.

Synthesis

350-03-8

4637-24-5

55314-16-4

Example-2: Preparation of 3-dimethylamino-1-pyridin-3-ylacrylone Method A: 3-Acetylpyridine (25 g, 0.20 mol), N,N-dimethylformamide dimethyl acetal (37 g, 0.31 mol) and acetic acid (2.5 ml) were mixed and the reaction was heated at 90-95°C for 2 hours, during which time the methanol produced was continuously removed. After completion of the reaction, excess methanol in the reaction was removed by distillation under reduced pressure. The reaction mixture was diluted with water and extracted with dichloromethane (125 ml). The organic layer was washed with water and the solvent was removed by distillation under reduced pressure to afford 34 g (92% yield) of (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one with a purity of 99.1% by HPLC analysis.

Solubility in organics

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one is soluble in chloroform and dichloromethane.

References

[1] Synlett, 2016, vol. 27, # 15, p. 2233 - 2236
[2] RSC Advances, 2018, vol. 8, # 47, p. 26828 - 26836
[3] Molecules, 2009, vol. 14, # 10, p. 4166 - 4179
[4] Patent: WO2011/39782, 2011, A1. Location in patent: Page/Page column 14
[5] Organic Process Research and Development, 2008, vol. 12, # 3, p. 490 - 495

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one Suppliers

Belgium 1 China 88 Finland 2 Germany 1 India 3 United Kingdom 1 United States 11 Global 107

Adamas Reagent, Ltd.

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Nanjing XiZe Biotechnology CO., Ltd.

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View Lastest Price from (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one manufacturers

Shandong Jihui Chemical Co., Ltd.

Product: (E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 123367-26-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: Purity: 98.0%
Supply Ability: 500tons
Release date: 2025-07-21

Career Henan Chemical Co

Product: (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one 123367-26-0
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

123367-26-0, (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-oneRelated Search:

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine 2-Propen-1-one, 1-[(3R)-3-[4-amino-7-oxido-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]- Imatinib Impurity 38 Ibrutinib Impurity 28 (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethanone Imatinib Impurity 4 Ibrutinib Impurity 5 Ibrutinib Dimer Impurity Imatinib Impurity 7 (S)-Ibrutinib (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide Ilutinib Methylxanthate Impurity C Ibrutinib Impurity D N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

(2E)-3-(DiMethylaMino)-1-(pyridin-3-yl)prop-2-en-1-one

(2E)-3-(DiMethylaMino)-1-(3-pyridyl)prop-2-en-1-one (IMpurity of Nilotinib)

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one

(E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

Imatinib EP Impurity A (Nilotinib Impurity 16)

Nilotinib Impurity 16 (Imatinib EP Impurity A)

Imatinib impurity 14/(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

(E)-3-(dimethylamino)

Nilotinib IMpurity ((2E)-3-(DiMethylaMino)-1-(3-pyridyl)prop-2-en-1-one)

Irutinib Impurity A

Imatinib impurity J

2-Propen-1-one, 3-(dimethylamino)-1-(3-pyridinyl)-, (2E)-

(E)-3-(Dimethylamino)-1-(3-pyridyl)-2-propen-1-one

Imatinib EP impuritiesA

Imatinib Mesilate Impurity A

(2E)-3-(Dimethylamino)-1-(3-Pyridyl)prtop-2-en-1-one

Imatinib Mesilate EP Impurity A

Imatinib Mesylate Imp A (pharmeuropa): (2E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

123367-26-0