ChemicalBook > CAS DataBase List > 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

Product Name
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
CAS No.
500579-04-4
Chemical Name
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
Synonyms
GNT61;CS-867;GANT 61;NSC 136476;GANT61, >=98%;GANT-61,NSC 136476;GANT 61, 10 mM in DMSO;GANT61;GANT 61;NSC 136476;GANT 61, GLI1 and 2 inhibitor;GANT61; GANT-61; NSC 136476;GANT 61
CBNumber
CB72518922
Molecular Formula
C27H35N5
Formula Weight
429.6
MOL File
500579-04-4.mol
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2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Property

Melting point:
110 - 113°C
Boiling point:
549.0±50.0 °C(Predicted)
Density 
1.134±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >2mg/mL
pka
5.97±0.10(Predicted)
form 
powder
color 
white to off-white
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G9048
Product name
GANT61
Purity
≥98% (HPLC)
Packaging
5mg
Price
$189
Updated
2024/03/01
Sigma-Aldrich
Product number
373403
Product name
InSolution? Hh/Gli Antagonist, GANT61
Packaging
2mg
Price
$113
Updated
2024/03/01
Cayman Chemical
Product number
13841
Product name
GANT 61
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
13841
Product name
GANT 61
Purity
≥98%
Packaging
10mg
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
G9048
Product name
GANT61
Purity
≥98% (HPLC)
Packaging
25mg
Price
$733
Updated
2024/03/01
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2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Chemical Properties,Usage,Production

Uses

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.

Definition

ChEBI: GANT61 is an aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor. It has a role as a Hedgehog signaling pathway inhibitor, a glioma-associated oncogene inhibitor, an antineoplastic agent and an apoptosis inducer. It is a tertiary amino compound, a member of pyridines, a substituted aniline and an aminal.

Biochem/physiol Actions

GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.

storage

+4°C

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Suppliers

China 117 India 2 United Kingdom 2 United States 22 Global 143
Carbosynth
Tel
--
Fax
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Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine manufacturers

Career Henan Chemical Co
Product
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine 500579-04-4
Price
US $1.00/ASSAYS
Min. Order
100ASSAYS
Purity
98%min
Supply Ability
G/KG/T
Release date
2019-12-20

500579-04-4, 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamineRelated Search:

CYCLOPAMINE Enzalutamide LDE225 (NVP-LDE225,Erismodegib) Vismodegib (GDC-0449) Dabrafenib SANT-1

  • 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
  • GANT 61
  • Benzenamine, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-
  • 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine] GANT61
  • GNT61
  • NSC 136476
  • InSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem
  • CS-867
  • GANT61; GANT-61; NSC 136476;GANT 61
  • GANT61;GANT 61;NSC 136476
  • GANT61, >=98%
  • GANT-61,NSC 136476
  • 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylanilin
  • InSolution? Hh/Gli Antagonist, GANT61
  • 2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline
  • 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine USP/EP/BP
  • 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline)
  • 2,2’-[[2-(4-Pyridyl)dihydropyrimidine-1,3(2H,4H)-diyl]bis(methylene)]bis(N,N-dimethylaniline)
  • GANT 61, GLI1 and 2 inhibitor
  • GANT 61, 10 mM in DMSO
  • 500579-04-4
  • C27H35N5
  • Inhibitors