2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

Product Name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
CAS No.: 500579-04-4
Chemical Name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
Synonyms: GNT61;CS-867;GANT 61;NSC 136476;GANT61, >=98%;GANT-61,NSC 136476;GANT61;GANT 61;NSC 136476;GANT61; GANT-61; NSC 136476;GANT 61;InSolution? Hh/Gli Antagonist, GANT61;InSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem
CBNumber: CB72518922
Molecular Formula: C27H35N5
Formula Weight: 429.6
MOL File: 500579-04-4.mol

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2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Property

Melting point:: 110 - 113°C
Boiling point:: 549.0±50.0 °C(Predicted)
Density: 1.134±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >2mg/mL
pka: 5.97±0.10(Predicted)
form: powder
color: white to off-white

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Safety

WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G9048
Product name: GANT61
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $189
Updated: 2024/03/01

Sigma-Aldrich

Product number: 373403
Product name: InSolution? Hh/Gli Antagonist, GANT61
Packaging: 2mg
Price: $113
Updated: 2024/03/01

Cayman Chemical

Product number: 13841
Product name: GANT 61
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 13841
Product name: GANT 61
Purity: ≥98%
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Sigma-Aldrich

Product number: G9048
Product name: GANT61
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $733
Updated: 2024/03/01

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2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Chemical Properties,Usage,Production

Uses

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.

Definition

ChEBI: GANT61 is an aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor. It has a role as a Hedgehog signaling pathway inhibitor, a glioma-associated oncogene inhibitor, an antineoplastic agent and an apoptosis inducer. It is a tertiary amino compound, a member of pyridines, a substituted aniline and an aminal.

Biochem/physiol Actions

GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.

storage

+4°C

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Suppliers

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View Lastest Price from 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine manufacturers

Career Henan Chemical Co

Product: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine 500579-04-4
Price: US $1.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-20

500579-04-4, 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamineRelated Search:

CYCLOPAMINE Enzalutamide LDE225 (NVP-LDE225,Erismodegib) Vismodegib (GDC-0449) Dabrafenib SANT-1

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

GANT 61

Benzenamine, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine] GANT61

GNT61

NSC 136476

InSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem

CS-867

GANT61; GANT-61; NSC 136476;GANT 61

GANT61;GANT 61;NSC 136476

GANT61, >=98%

GANT-61,NSC 136476

2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylanilin

InSolution? Hh/Gli Antagonist, GANT61

2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine USP/EP/BP

2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline)

2,2’-[[2-(4-Pyridyl)dihydropyrimidine-1,3(2H,4H)-diyl]bis(methylene)]bis(N,N-dimethylaniline)

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

2,2’-[[2-(4-Pyridyl)dihydropyrimidine-1,3(2H,4H)-diyl]bis(methylene)]bis(N,N-dimethylaniline)

2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline)

500579-04-4

C27H35N5

Inhibitors