ChemicalBook > CAS DataBase List > Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride

Product Name
Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride
CAS No.
76308-26-4
Chemical Name
Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride
Synonyms
Cariprazine Impurity 7;Ethyl 2-(trans-4-aminocyclohexyl);Ethyl trans-4-amino-cyclohexaneacetate HCl;Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl;ETHYL 2-(4-AMINOCYCLOHEXYL)ACETATE;HYDROCHLORIDE;ethyl (trans-4-aminocyclohexyl)acetate hydrochloride;Ethyl 2-(trans-4-aMinocyclohexyl)acetate hydrochloride;Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride;ethyl 2-[(1r,4r)-4-aminocyclohexyl]acetate hydrochloride;Ethyl (trans-4-aminocyclohexyl)acetate hydrochloride (1:1)
CBNumber
CB72520257
Molecular Formula
C10H20ClNO2
Formula Weight
221.73
MOL File
76308-26-4.mol
More
Less

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Property

Melting point:
177 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1/C10H19NO2.ClH/c1-2-13-10(12)7-8-3-5-9(11)6-4-8;/h8-9H,2-7,11H2,1H3;1H/t8-,9-;
InChIKey
KBMWRCPPPDEVSJ-JUAUBFSONA-N
SMILES
C([C@@H]1CC[C@@H](N)CC1)C(=O)OCC.Cl |&1:1,4,r|
More
Less

Safety

HS Code 
2922.49.8000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
E1374
Product name
Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride
Packaging
1G
Price
$127
Updated
2024/03/01
TCI Chemical
Product number
E1374
Product name
Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride
Packaging
5G
Price
$507
Updated
2024/03/01
TRC
Product number
E899695
Product name
Ethyltrans-2-(4-aminocyclohexyl)acetatehydrochloride
Packaging
500mg
Price
$50
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0392375
Product name
ETHYL-2-(TRANS-4-AMINOCYCLOHEXYL)ACETATE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$500.36
Updated
2021/12/16
AK Scientific
Product number
1869AC
Product name
Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride
Packaging
10g
Price
$628
Updated
2021/12/16
More
Less

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Chemical Properties,Usage,Production

Uses

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis


Preparation of trans 4-amino-cyclohexyl-acetic acid ethyl ester HClA 2500 1 enamelled autoclave is charged with 1000 kg of deionizated water and 210 kg (1.16 kM) of 4-nitrophenyl-acetic acid at room temperature under nitrogen atmosphere. After inertisation by nitrogen to the mixture obtained a suspension of 21 kg of 10% Pd/C in 20 kg of deionized water is added and the catalyst measuring gauge is rinsed by additional 20 kg of deionizated water. After rinsing the reaction vessel by hydrogen gas the hydrogenation is carried out at a temperature between 44-46??C and under up to 0,6 bar overpressure until the hydrogen uptake is slowed. After reducing the nitro group the temperature is brought to 55- 58??C and the hydrogenation continued maintaining hydrogen pressure on max. 4.0 bar overpressures. After completion of the hydrogen uptake, the mixture is cooled to a temperature between 25-30??C, purged with nitrogen and the catalyst is filtered on a Spakler filter under pressurized nitrogen. The reaction vessel, the filter and the lines are washed additional 200 g of deionized water. The filtrates are combined and in a 2500 1 enamelled doubler 1200 kg of distillate is distilled at up to 80??C inner temperature in vacuum. The residue obtained is cooled to a temperature below 30??C and 430 kg of ethyl alcohol is added, then 500 1 of distillate is collected at up to 80??C under vacuum. After completion of the distillation the mixture is cooled to a temperature between 25-30??C, (water content is max. 10 w%, in terms of absolute value is about 32 kg), and 550 kg of ethyl alcohol, then 170 kg of 30% hydrochloric ethyl alcohol are added and the reaction mixture is heated to reflux for approx. 2 hours. When the esterification is complete 800 1 of solvent is distilled off at up to 80??C, under vacuum. Additional 800 1 of ethyl alcohol is added and further 750-800 1 of solvent is distilled off at up to 80??C, under vacuum. To the residue obtained 700 kg of acetonitrile is added and 140 1 of distillate is collected at up to 80??C under vacuum. The vacuum is stopped by introducing nitrogen and the solution is cooled to a temperature between 0-(-)5??C. The crystals obtained is centrifuged, washed with 100 kg of acetonitrile in two portions during which the temperature is kept at 0-(-)5??C. The solid obtained is dried to a constant weight at up to 6O0C. In this manner 90 kg of title product is obtained. Yield: 40 %. Melting point: 173-1760C.

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Suppliers

TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
More
Less

View Lastest Price from Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride manufacturers

Shanghai Yongzeng Technology Co.,Ltd
Product
Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride 76308-26-4
Price
US $0.00/gm
Min. Order
100gm
Purity
98%min
Supply Ability
100kgs
Release date
2024-09-02
Pharmahands (Taizhou) Co., Ltd.
Product
Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride 76308-26-4
Price
US $3500.00/Kg/Bag
Min. Order
1g
Purity
98%
Supply Ability
50/month
Release date
2020-10-29
Career Henan Chemical Co
Product
Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride 76308-26-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg;10kg;100kg
Release date
2019-08-29

76308-26-4, Ethyl trans-2-(4-Aminocyclohexyl)acetate HydrochlorideRelated Search:


  • Ethyl (trans-4-aminocyclohexyl)acetate hydrochloride (1:1)
  • ethyl 2-[(1r,4r)-4-aminocyclohexyl]acetate hydrochloride
  • Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride
  • Cyclohexaneacetic acid, 4-aMino-,ethyl ester (hydrochloride)(1:1), trans-
  • Ethyl 2-(trans-4-aMinocyclohexyl)acetate hydrochloride
  • Cariprazine Impurity 7
  • trans-4-Aminocyclohexaneacetic acid ethyl ester hydrochloride
  • trans-2-(4-Aminocyclohexyl)acetic acid ethyl ester hydrochloride
  • Ethyl 2-(trans-4-aminocyclohexyl)
  • ETHYL 2-(4-AMINOCYCLOHEXYL)ACETATE;HYDROCHLORIDE
  • Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl
  • ethyl (trans-4-aminocyclohexyl)acetate hydrochloride
  • Ethyl trans-4-amino-cyclohexaneacetate HCl
  • 76308-26-4
  • 76308-26-4