Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride

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Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride

Product Name: Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride
CAS No.: 76308-26-4
Chemical Name: Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride
Synonyms: Cariprazine Impurity 7;Ethyl 2-(trans-4-aminocyclohexyl);Ethyl trans-4-amino-cyclohexaneacetate HCl;Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl;ETHYL 2-(4-AMINOCYCLOHEXYL)ACETATE;HYDROCHLORIDE;ethyl (trans-4-aminocyclohexyl)acetate hydrochloride;Ethyl 2-(trans-4-aMinocyclohexyl)acetate hydrochloride;Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride;ethyl 2-[(1r,4r)-4-aminocyclohexyl]acetate hydrochloride;Ethyl (trans-4-aminocyclohexyl)acetate hydrochloride (1:1)
CBNumber: CB72520257
Molecular Formula: C10H20ClNO2
Formula Weight: 221.73
MOL File: 76308-26-4.mol

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Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Property

Melting point:: 177 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1/C10H19NO2.ClH/c1-2-13-10(12)7-8-3-5-9(11)6-4-8;/h8-9H,2-7,11H2,1H3;1H/t8-,9-;
InChIKey: KBMWRCPPPDEVSJ-JUAUBFSONA-N
SMILES: C([C@@H]1CC[C@@H](N)CC1)C(=O)OCC.Cl |&1:1,4,r|

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Safety

HS Code: 2922.49.8000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1374
Product name: Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride
Packaging: 1G
Price: $127
Updated: 2024/03/01

TCI Chemical

Product number: E1374
Product name: Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride
Packaging: 5G
Price: $507
Updated: 2024/03/01

TRC

Product number: E899695
Product name: Ethyltrans-2-(4-aminocyclohexyl)acetatehydrochloride
Packaging: 500mg
Price: $50
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0392375
Product name: ETHYL-2-(TRANS-4-AMINOCYCLOHEXYL)ACETATE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $500.36
Updated: 2021/12/16

AK Scientific

Product number: 1869AC
Product name: Ethyl 2-(trans-4-Aminocyclohexyl)acetate Hydrochloride
Packaging: 10g
Price: $628
Updated: 2021/12/16

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Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Chemical Properties,Usage,Production

Uses

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

Preparation of trans 4-amino-cyclohexyl-acetic acid ethyl ester HClA 2500 1 enamelled autoclave is charged with 1000 kg of deionizated water and 210 kg (1.16 kM) of 4-nitrophenyl-acetic acid at room temperature under nitrogen atmosphere. After inertisation by nitrogen to the mixture obtained a suspension of 21 kg of 10% Pd/C in 20 kg of deionized water is added and the catalyst measuring gauge is rinsed by additional 20 kg of deionizated water. After rinsing the reaction vessel by hydrogen gas the hydrogenation is carried out at a temperature between 44-46??C and under up to 0,6 bar overpressure until the hydrogen uptake is slowed. After reducing the nitro group the temperature is brought to 55- 58??C and the hydrogenation continued maintaining hydrogen pressure on max. 4.0 bar overpressures. After completion of the hydrogen uptake, the mixture is cooled to a temperature between 25-30??C, purged with nitrogen and the catalyst is filtered on a Spakler filter under pressurized nitrogen. The reaction vessel, the filter and the lines are washed additional 200 g of deionized water. The filtrates are combined and in a 2500 1 enamelled doubler 1200 kg of distillate is distilled at up to 80??C inner temperature in vacuum. The residue obtained is cooled to a temperature below 30??C and 430 kg of ethyl alcohol is added, then 500 1 of distillate is collected at up to 80??C under vacuum. After completion of the distillation the mixture is cooled to a temperature between 25-30??C, (water content is max. 10 w%, in terms of absolute value is about 32 kg), and 550 kg of ethyl alcohol, then 170 kg of 30% hydrochloric ethyl alcohol are added and the reaction mixture is heated to reflux for approx. 2 hours. When the esterification is complete 800 1 of solvent is distilled off at up to 80??C, under vacuum. Additional 800 1 of ethyl alcohol is added and further 750-800 1 of solvent is distilled off at up to 80??C, under vacuum. To the residue obtained 700 kg of acetonitrile is added and 140 1 of distillate is collected at up to 80??C under vacuum. The vacuum is stopped by introducing nitrogen and the solution is cooled to a temperature between 0-(-)5??C. The crystals obtained is centrifuged, washed with 100 kg of acetonitrile in two portions during which the temperature is kept at 0-(-)5??C. The solid obtained is dried to a constant weight at up to 6O0C. In this manner 90 kg of title product is obtained. Yield: 40 %. Melting point: 173-1760C.

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride manufacturers

Shanghai Yongzeng Technology Co.,Ltd

Product: Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride 76308-26-4
Price: US $0.00/gm
Min. Order: 100gm
Purity: 98%min
Supply Ability: 100kgs
Release date: 2024-09-02

Pharmahands (Taizhou) Co., Ltd.

Product: Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride 76308-26-4
Price: US $3500.00/Kg/Bag
Min. Order: 1g
Purity: 98%
Supply Ability: 50/month
Release date: 2020-10-29

Career Henan Chemical Co

Product: Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride 76308-26-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg;10kg;100kg
Release date: 2019-08-29

76308-26-4, Ethyl trans-2-(4-Aminocyclohexyl)acetate HydrochlorideRelated Search:

Cariprazine intermediate 2 Desmethyl Cariprazine Piperazine, 1-(2-chloroethyl)-4-(2,3-dichlorophenyl)- Urea, N,N'-bis[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]- Urea, N,N-dimethyl-N'-[trans-4-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]cyclohexyl]- ethyl dimethylcarbamate 3,3-dimethyl-1-[(1r,4r)-4-(2-hydroxyethyl)cyclohexyl]urea Cyclohexaneethanol, 4-amino-, hydrochloride (1:1), trans- CarbaMic acid, N-[trans-4-(2-hydroxyethyl)cyclohexyl]-, 1,1-diMethylethyl ester Ethyl trans-2-[4-(Boc-aMino)cyclohexyl]acetate

Ethyl (trans-4-aminocyclohexyl)acetate hydrochloride (1:1)

ethyl 2-[(1r,4r)-4-aminocyclohexyl]acetate hydrochloride

Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride

Cyclohexaneacetic acid, 4-aMino-,ethyl ester (hydrochloride)(1:1), trans-

Ethyl 2-(trans-4-aMinocyclohexyl)acetate hydrochloride

Cariprazine Impurity 7

trans-4-Aminocyclohexaneacetic acid ethyl ester hydrochloride

trans-2-(4-Aminocyclohexyl)acetic acid ethyl ester hydrochloride

Ethyl 2-(trans-4-aminocyclohexyl)

ETHYL 2-(4-AMINOCYCLOHEXYL)ACETATE;HYDROCHLORIDE

Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl

ethyl (trans-4-aminocyclohexyl)acetate hydrochloride

Ethyl trans-4-amino-cyclohexaneacetate HCl

76308-26-4