ChemicalBook > CAS DataBase List > Avatrombopag

Avatrombopag

Product Name
Avatrombopag
CAS No.
570406-98-3
Chemical Name
Avatrombopag
Synonyms
Avatrombopag Base,Avatrombopag;AKR-501;Crenolanib Besylate;Avatrombopag (AKR-501);YM477;E 5501;AS 1670542;AVATROMBOPAG;AKR-501 USP/EP/BP;Avatrombopag Crude
CBNumber
CB72522099
Molecular Formula
C29H34Cl2N6O3S2
Formula Weight
649.65
MOL File
570406-98-3.mol
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Avatrombopag Property

Density 
1.440
solubility 
DMSO:27.33(Max Conc. mg/mL);42.07(Max Conc. mM)
form 
A crystalline solid
pka
3.04±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3397
Product name
Avatrombopag
Packaging
5mg
Price
$420
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008153
Product name
AKR-501
Purity
95.00%
Packaging
5MG
Price
$502.93
Updated
2021/12/16
ChemScene
Product number
CS-3397
Product name
Avatrombopag
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-3397
Product name
Avatrombopag
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-3397
Product name
Avatrombopag
Packaging
100mg
Price
$2520
Updated
2021/12/16
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Avatrombopag Chemical Properties,Usage,Production

Description

Avatrombopag is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.It was the third thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia and the first approved to treat periprocedural thrombocytopenia in patients with chronic liver disease (thereby providing an alternative to blood transfusions for these patients). Avatrombopag was approved for medical use in the United States in 2018, and in the European Union in 2019.

Uses

Avatrombopag is used to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in people with chronic (ongoing) liver disease. It is also used to treat thrombocytopenia in people with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood).

Mechanism of action

Avatrombopag is in a class of medications called thrombopoietin (TPO) receptor agonists. It works by causing the body to produce more platelets.

target

TPO receptor

IC 50

IC 50 value is 3.3 nM.

Avatrombopag Preparation Products And Raw materials

Raw materials

Preparation Products

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Avatrombopag Suppliers

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View Lastest Price from Avatrombopag manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Avatrombopag (AKR-501) 570406-98-3
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-01
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
Avatrombopag Base,Avatrombopag 570406-98-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
＞99% by HPLC
Supply Ability
5kg/Month
Release date
2023-01-05
Nanjing Kaitian Chemical Co., LTD
Product
Avatrombopag 570406-98-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2023-02-10

570406-98-3, AvatrombopagRelated Search:

Unii-4U07F515lg Eltrombopag Ibopamine Hydrochloride Lusutrombopag Lusutrombopag methyl 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate Avatrombopag maleate 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

  • Avatrombopag Base,Avatrombopag
  • Avatrombopag (AKR-501)
  • AVATROMBOPAG
  • AS 1670542
  • E 5501
  • 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-
  • Avatrombopag(AS1670542)
  • Crenolanib Besylate
  • 1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid
  • 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbo
  • AKR-501
  • 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid
  • 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid
  • AKR-501; YM477; E5501; AS 1670542
  • YM477
  • AKR-501 USP/EP/BP
  • 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2
  • 4- (2- (6- (4-carboxypyridine-1-yl) - (5-chloronicotinamide) -4- (4-chlorothienyl-2-yl) thiazol-5-yl) -1-cyclohexylpiperazine
  • 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid (Avatrombopag Impurity)
  • 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
  • Avatrombopag Monomer
  • Avatrombopag Crude
  • 570406-98-3
  • C29H34Cl2N6O3S2
  • Intermediate
  • API