ChemicalBook > CAS DataBase List > Avatrombopag

Avatrombopag

Product Name: Avatrombopag
CAS No.: 570406-98-3
Chemical Name: Avatrombopag
Synonyms: Avatrombopag Base,Avatrombopag;AKR-501;Crenolanib Besylate;Avatrombopag (AKR-501);YM477;E 5501;AS 1670542;AVATROMBOPAG;D8-Avatrombopag;AKR-501 USP/EP/BP
CBNumber: CB72522099
Molecular Formula: C29H34Cl2N6O3S2
Formula Weight: 649.65
MOL File: 570406-98-3.mol

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Avatrombopag Property

Density: 1.440
storage temp.: Storage temp. 2-8°C
solubility: DMSO:27.33(Max Conc. mg/mL);42.07(Max Conc. mM)
form: A crystalline solid
pka: 3.04±0.70(Predicted)
color: White to off-white
InChIKey: OFZJKCQENFPZBH-UHFFFAOYSA-N
SMILES: N1(C2=NC=C(C(NC3=NC(C4SC=C(Cl)C=4)=C(N4CCN(C5CCCCC5)CC4)S3)=O)C=C2Cl)CCC(C(O)=O)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML4174
Product name: Avatrombopag
Purity: ≥98% (HPLC)
Packaging: 1 unit
Price: $139
Updated: 2025/07/31

ChemScene

Product number: CS-3397
Product name: Avatrombopag
Packaging: 5mg
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008153
Product name: AKR-501
Purity: 95.00%
Packaging: 5MG
Price: $502.93
Updated: 2021/12/16

ChemScene

Product number: CS-3397
Product name: Avatrombopag
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-3397
Product name: Avatrombopag
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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Avatrombopag Chemical Properties,Usage,Production

Description

Avatrombopag is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.It was the third thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia and the first approved to treat periprocedural thrombocytopenia in patients with chronic liver disease (thereby providing an alternative to blood transfusions for these patients). Avatrombopag was approved for medical use in the United States in 2018, and in the European Union in 2019.

Uses

Avatrombopag is used to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in people with chronic (ongoing) liver disease. It is also used to treat thrombocytopenia in people with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood).

Mechanism of action

Avatrombopag is in a class of medications called thrombopoietin (TPO) receptor agonists. It works by causing the body to produce more platelets.

in vivo

Avatrombopag (0.3-3 mg/kg; p.o.; daily for 14 days) increases the number of human platelets in NOD/SCID mice transplanted with human FL CD34⁺ cells^[1].

Animal Model:	NOD/SCID mice (transplanted with human FL CD34+cells)^[1]
Dosage:	0.3, 1, and 3?mg/kg
Administration:	P.o.; daily for 14 days
Result:	Dose-dependently increased the number of human platelets, resulting in approximately a 2.7‐fold increase at 1 mg/kg/d and a 3.0-fold increase at 3 mg/kg/d on day 14 after the start of administration.

target

TPO receptor

IC 50

IC 50 value is 3.3 nM.

Avatrombopag Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Avatrombopag manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: avatrombopag 570406-98-3
Price: US $2.00-5.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-10

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: Avatrombopag Base,Avatrombopag 570406-98-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞99% by HPLC
Supply Ability: 5kg/Month
Release date: 2023-01-05

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Avatrombopag (AKR-501) 570406-98-3
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-01

570406-98-3, AvatrombopagRelated Search:

Unii-4U07F515lg Eltrombopag Ibopamine Hydrochloride Lusutrombopag Lusutrombopag methyl 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate Avatrombopag maleate 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

Avatrombopag Base,Avatrombopag

Avatrombopag (AKR-501)

AVATROMBOPAG

AS 1670542

E 5501

4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-

Avatrombopag(AS1670542)

Crenolanib Besylate

1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid

1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbo

AKR-501

1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid

1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid

AKR-501; YM477; E5501; AS 1670542

YM477

AKR-501 USP/EP/BP

1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2

4- (2- (6- (4-carboxypyridine-1-yl) - (5-chloronicotinamide) -4- (4-chlorothienyl-2-yl) thiazol-5-yl) -1-cyclohexylpiperazine

1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid (Avatrombopag Impurity)

1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid

Avatrombopag Monomer

Avatrombopag Crude

Avatricoppa (AKR-501)

Avatrombopag Impurity(AKR 501)

Avatrombopag, 10 mM in DMSO

D8-Avatrombopag

1-(3-Chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid (711-I4)

570406-98-3

C29H34Cl2N6O3S2

Intermediate

API