Fmoc-Lys(N3)-OH

Product Name: Fmoc-Lys(N3)-OH
CAS No.: 159610-89-6
Chemical Name: Fmoc-Lys(N3)-OH
Synonyms: Fmoc-L-Lys(N3)-OH;FMoc-L-azidolysine;N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-diazo-L-lysine;Fmoc-Lys(N3);Fmoc-Lys(N3)-OH;FMoc-Lys(N2)-OH;Fmoc-Lys(N?)-OH;Fmoc-azidolysine;Fmoc-Azido-Lys-OH;FMoc-e-azido-Nle-OH
CBNumber: CB72524154
Molecular Formula: C21H22N4O4
Formula Weight: 394.43
MOL File: 159610-89-6.mol

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Fmoc-Lys(N3)-OH Property

Melting point:: 78 °C(dec.)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: powder to crystal
color: White to Almost white
InChIKey: PJRFTUILPGJJIO-DETXXQSHNA-N
SMILES: C(C1C2=CC=CC=C2C2=CC=CC=C12)OC(=O)N[C@H](C(=O)O)CCCCN=[N+]=[N-] |&1:18,r|

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Safety

HS Code: 2929900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52326
Product name: Fmoc-azidolysine
Purity: Novabiochem®
Packaging: 1 g
Price: $785
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52326
Product name: Fmoc-azidolysine
Purity: Novabiochem®
Packaging: 5 g
Price: $910
Updated: 2025/07/31

TCI Chemical

Product number: A3023
Product name: 6-Azido-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine
Purity: >98.0%(HPLC)(T)
Packaging: 250mg
Price: $165
Updated: 2025/07/31

TRC

Product number: F657733
Product name: Fmoc-L-Azidolysine
Packaging: 25mg
Price: $75
Updated: 2021/12/16

Chem-Impex

Product number: 29756
Product name: Nα-Fmoc-Nε-azide-L-Lysine,98.0-100.5%(Assaybytitration)
Purity: 98.0-100.5%(Assaybytitration)
Packaging: 250MG
Price: $89.6
Updated: 2021/12/16

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Fmoc-Lys(N3)-OH Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

The side chain azido (N3) group is stable in trifluoroacetic acid or piperidine. It can be readily converted to amine and to synthesis side chain modified peptides and proteins by Solid Phase Peptide Synthesis (SPPS) methodology.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

105047-45-8

159610-89-6

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid (Fmoc-lysine, 2.03 g, 5.51 mmol) was used as a starting material, which was co-dissolved in methanol (70 mL) with CuSO4 (88 mg, 0.35 mmol) and K2CO3 (2.46 g, 17.83 mmol). Subsequently, imidazole-1-sulfonyl azide hydrochloride (3,1.40 g, 6.70 mmol) was added in batches and the resulting suspension was stirred overnight at room temperature. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was redissolved in dichloromethane (50 mL). The resulting solution was washed with 1 M aqueous hydrochloric acid (50 mL) and the aqueous phase was re-extracted with dichloromethane (3 x 50 mL). The organic phases were combined and the crude product was purified by gradient column chromatography (eluent ratio: dichloromethane/methanol/acetic acid, 96.5%/3%/0.5% → 93.5%/6%/0.5%). The purified product was lyophilized from dioxane to give a colorless oil (1.94 g, 89% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3) and HRMS (ESI+): 1H-NMR δ 7.76 (d, J = 7.5 Hz, 2H), 7.59 (d, J = 6.9 Hz, 2H), 7.40 (t, J = 7.5 Hz, 2H), 7.31 (t, J = 7.5 Hz, 2H), 5.34 (d, J = 7.8 Hz, 1H), 4.54 (br s, 1H), 4.43 (d, J = 6.6 Hz, 2H), 4.22 (t, J = 6.6 Hz, 1H), 3.27 (t, J = 6.6 Hz, 2H), 1.3-2.0 (m, 2H); HRMS (ESI+) m/z calcd for C21H23N4O4 [M + H ]+ 395.1719, found 395.1718.

References

[1] European Journal of Organic Chemistry, 2015, vol. 2015, # 5, p. 1117 - 1129
[2] Chemical Communications, 2011, vol. 47, # 9, p. 2589 - 2591
[3] Chemical Communications, 2018, vol. 54, # 23, p. 2846 - 2849
[4] Patent: EP2532639, 2012, A1. Location in patent: Page/Page column 5; 6
[5] Angewandte Chemie, International Edition, 2015, vol. 54, # 19, p. 5784 - 5788

Fmoc-Lys(N3)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Lys(N3)-OH Suppliers

Americas 1 Canada 1 China 102 Europe 1 France 2 Germany 5 India 6 Japan 5 Latvia 1 Spain 1 Switzerland 2 The Netherlands 1 United Kingdom 4 United States 29 Global 161

Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
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Alabiochem Tech.Co., Ltd.

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Fax: 0086-512-56765862
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Aikon International Limited

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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GL Biochem (Shanghai) Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

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Chemsky (shanghai) International Co.,Ltd

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ChemPep, Inc.

Tel: +1 (888) 615-9178 / (561) 791-8787
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Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
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View Lastest Price from Fmoc-Lys(N3)-OH manufacturers

Career Henan Chemical Co

Product: Fmoc-Lys(N3)-OH 159610-89-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-03

159610-89-6, Fmoc-Lys(N3)-OHRelated Search:

(s)-3-(fmoc-amino)-n-trityl-adipic acid 6-amide Fmoc-D-Lys(ipr,Boc)-OH FMOC-LYS(MCA)-OH FMOC-LYS(ALOC)-OH Fmoc-Lys(nicotinoyl)-OH FMOC-LYS(5-FAM)-OH Fmoc-HoLys(N3)-OH Fmoc-Lys(Ddiv)-OH FMOC-LYS(FMOC)-OH FMoc-Lys-AMC.HCl FMOC-L-LYS(DANSYL)-OH FMoc-Aea-OH N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE FMOC-LYS(BOC)(ME)-OH FMOC-LYS(ME)2-OH HCL FMOC-LYS(DNP)-OH Fmoc-Lys(Trt)-OH FMOC-LYS(ME3)-OH HCL

Fmoc-ε-azido-Nle-OH

Fmoc-Lys(N3)-OH

FMoc-L-azidolysine

FMoc-e-azido-Nle-OH

FMoc-Lys(N2)-OH

(2S)-N-FMoc-6-azido--Hexanoic acid

(2S)-N-FMoc-5-azido- hexanoic acid

6-Azido-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine

6-Azido-N-Fmoc-L-norleucine

Fmoc-L-Lys(N3)-OH

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-azidohexanoic acid

6-Azido-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine

Nα-Fmoc-Nε-azide-L-Lysine≥ 99.9% (HPLC, Chiral purity)

(2S)-6-azido-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

(9H-Fluoren-9-yl)MethOxy]Carbonyl Lys(N3)-OH

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-diazo-L-lysine

L-Norleucine, 6-azido-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Nα-Fmoc-Nε-azide-L-Lysine

Fmoc-Lys(N?)-OH

Fmoc-e-azido-Nle-OH (B-4135.0250)

N-alpha-Fmoc-epsilon-azido-L-lysine

N6-Diazo-L-Fmoc-lysine

6-Azido-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L<

Fmoc-azidolysine

Fmoc-Azido-Lys-OH

Fmoc-6-azido-L-norleucine

Fmoc-Lys(N3)

159610-89-6

amino acids

Fmoc Amino Acids