6-Quinazolinol, 4-chloro-7-methoxy-

Product Name: 6-Quinazolinol, 4-chloro-7-methoxy-
CAS No.: 574745-97-4
Chemical Name: 6-Quinazolinol, 4-chloro-7-methoxy-
Synonyms: 4-chloro-7-Methoxyquinazolin-6-ol;4-Chloro-6-hydroxy-7-Methoxyquinazoline;4-Chloro-6-hydroxy-7-meth...;6-Quinazolinol, 4-chloro-7-methoxy-
CBNumber: CB72525232
Molecular Formula: C9H7ClN2O2
Formula Weight: 210.62
MOL File: 574745-97-4.mol

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6-Quinazolinol, 4-chloro-7-methoxy- Property

Boiling point:: 355.8±37.0 °C(Predicted)
Density: 1.458±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 7.55±0.40(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C377283
Product name: 4-chloro-7-methoxyquinazolin-6-ol
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 068427
Product name: 4-Chloro-6-hydroxy-7-methoxyquinazoline
Purity: >95%
Packaging: 100mg
Price: $53
Updated: 2021/12/16

Matrix Scientific

Product number: 068427
Product name: 4-Chloro-6-hydroxy-7-methoxyquinazoline
Purity: >95%
Packaging: 250mg
Price: $106
Updated: 2021/12/16

AK Scientific

Product number: 5900AE
Product name: 4-Chloro-6-hydroxy-7-methoxyquinazoline
Packaging: 100mg
Price: $121
Updated: 2021/12/16

Matrix Scientific

Product number: 068427
Product name: 4-Chloro-6-hydroxy-7-methoxyquinazoline
Purity: >95%
Packaging: 500mg
Price: $163
Updated: 2021/12/16

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6-Quinazolinol, 4-chloro-7-methoxy- Chemical Properties,Usage,Production

Synthesis

230955-75-6

574745-97-4

General procedure for the synthesis of 4-chloro-7-methoxy-6-ol from 6-acetoxy-4-chloro-7-methoxyquinazoline: 4-chloro-7-methoxyquinazolin-6-yl acetate (prepared according to the method described in Example 25-5 of WO01/66099, 10.1 g, 40 mmol) was suspended in 6 N methanol-ammonia solution (200 mL) and stirred at room temperature for 90 minutes at room temperature. Upon completion of the reaction, the solvent was removed by evaporation under vacuum. Water was added to the residue and the resulting suspension was filtered. The collected solids were washed sequentially with water and ether and subsequently dried at high temperature. Finally, vacuum drying in the presence of phosphorus pentoxide gave 4-chloro-7-methoxyquinazolin-6-ol (7.9 g, 94% yield). The NMR hydrogen spectrum (DMSO-d6) data were as follows: δ 4.02 (s, 3H), 7.40 (s, 1H), 7.43 (s, 1H), 8.81 (s, 1H).

References

[1] Patent: WO2005/26151, 2005, A1. Location in patent: Page/Page column 124
[2] European Journal of Medicinal Chemistry, 2018, vol. 147, p. 130 - 149
[3] Patent: CN106986895, 2017, A. Location in patent: Paragraph 0072; 0073; 0074; 0075; 0076
[4] Patent: CN105384699, 2016, A. Location in patent: Paragraph 0032; 0033
[5] Patent: CN105418517, 2016, A. Location in patent: Paragraph 0026; 0030; 0031

6-Quinazolinol, 4-chloro-7-methoxy- Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Quinazolinol, 4-chloro-7-methoxy- Suppliers

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View Lastest Price from 6-Quinazolinol, 4-chloro-7-methoxy- manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-chloro-7-methoxyquinazolin-6-ol 574745-97-4
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

574745-97-4, 6-Quinazolinol, 4-chloro-7-methoxy-Related Search:

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6-Quinazolinol, 4-chloro-7-methoxy-

4-Chloro-6-hydroxy-7-meth...

574745-97-4