8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione

Product Name: 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
CAS No.: 853029-57-9
Chemical Name: 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
Synonyms: 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione;1-[(4-Methylquinazolin-2-yl)Methyl]-3-Methyl-7-(2-butin-1-yl)-8-broMoxanthine;8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione;1-[(4-Methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromoxanthine;Linaint-H;Linagliptin-1;8-Bromo-7-but;LIP-1A IMPURITY;Linagliptin Impurity 32;Linagliptin Impurity 94
CBNumber: CB72535826
Molecular Formula: C20H17BrN6O2
Formula Weight: 453.29
MOL File: 853029-57-9.mol

More

Less

8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione Property

Melting point:: >255°C (dec.)
Boiling point:: 602.9±65.0 °C(Predicted)
Density: 1.55
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Very Slightly, Heated, Sonicated)
pka: 2.34±0.50(Predicted)
form: Solid
color: White to Pale Yellow
InChI: InChI=1S/C20H17BrN6O2/c1-4-5-10-26-16-17(24-19(26)21)25(3)20(29)27(18(16)28)11-15-22-12(2)13-8-6-7-9-14(13)23-15/h6-9H,10-11H2,1-3H3
InChIKey: RCZJXCXNYGHNSR-UHFFFAOYSA-N
SMILES: N1(CC#CC)C2=C(N(C)C(=O)N(CC3=NC(C)=C4C(=N3)C=CC=C4)C2=O)N=C1Br

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: B680510
Product name: 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
Packaging: 1g
Price: $65
Updated: 2021/12/16

TRC

Product number: B680510
Product name: 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
Packaging: 10g
Price: $340
Updated: 2021/12/16

TRC

Product number: B680510
Product name: 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
Packaging: 25g
Price: $520
Updated: 2021/12/16

Matrix Scientific

Product number: 095321
Product name: 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquin-azolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
Purity: 95+%
Packaging: 5g
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: X4789
Product name: 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
Packaging: 5g
Price: $299
Updated: 2021/12/16

More

Less

8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione Chemical Properties,Usage,Production

Uses

8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione is an intermediate used to prepare selective inhibitors of dipeptidyl peptidase 4 (DPP4) for potential use in the treatment of type 2 diabetes.

Synthesis

666816-98-4

109113-72-6

853029-57-9

General procedure: 3-methyl-7-(2-butyn-1-yl)-8-bromoxanthine (Compound VII, 1.34 g, 4.5 mmol), potassium carbonate (1.42 g, 10.3 mmol), 2-chloromethyl-4-methylquinazoline (Compound III, 0.87 g, 4.5 mmol), tributylmethylammonium chloride (phase transfer catalyst, 0.53 g , 2 mmol) and 2-methyltetrahydrofuran (50 mL) were added sequentially to the reaction flask. The reaction mixture was heated to reflux and maintained for 3 to 5 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of water (100 mL). The reaction mixture was filtered, the filter cake was collected and dried at 45 °C to afford 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromoxanthine (Compound VIII). Yield: 1.78 g (87.1% yield). Mass spectrum (MS): [M + H]+ = 453/455. 1H-NMR (400 MHz, DMSO-d6): δ 1.79 (t, J = 2.3 Hz, 3H), 2.89 (s, 3H), 3.44 (s, 3H), 5.11 (q, J = 2.2 Hz, 2H), 5.35 (s, 2H), 7.67 (m, 1H), 7.80 (d, J = 8.3 Hz, 1H), 7.75 ( m, 1H), 8.24 (d, J = 8.1 Hz, 1H).

References

[1] Patent: WO2005/51950, 2005, A1. Location in patent: Page/Page column 18
[2] Patent: US2015/274728, 2015, A1. Location in patent: Paragraph 0070-0074
[3] Patent: WO2015/87240, 2015, A1. Location in patent: Page/Page column 12
[4] Patent: , 2016, . Location in patent: Paragraph 0045; 0046; 0047; 0048
[5] Patent: CN105936634, 2016, A. Location in patent: Paragraph 0064; 0065; 0066; 0067

8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione Suppliers

China 260 India 16 United Kingdom 1 United States 5 Global 282

Shandong Sihuan Pharmaceutical Co., Ltd.

Tel: 0531-88993893 13335127975
Fax: QQ:787658403
Email: fairouz@sdsihuanpharm.com
Country: China
ProdList: 82
Advantage: 58

Suzhou Yuanhuan Pharmaceutical Technology Co., Ltd.

Tel: 0512-18136053398 18136053398
Email: 2982784935@qq.com
Country: China
ProdList: 66
Advantage: 58

Beijing Huikang Boyuan Chemical Tech Co., Ltd

Tel: 010-68862197 13810598707
Fax: 010-68882204
Email: sales@huikangchem.com
Country: China
ProdList: 109
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2809
Advantage: 65

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Jinan Bond Chemical Technology Co., Ltd.

Tel: 86-531-88280989
Fax: 86-531-88280989
Email: mymail1996@126.com
Country: China
ProdList: 256
Advantage: 55

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

More

Less

View Lastest Price from 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione 853029-57-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Shaanxi Dideu New Materials Co. Ltd

Product: 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione 853029-57-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-13

Nanjing Fred Technology Co., Ltd

Product: 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione 853029-57-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-03

853029-57-9, 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dioneRelated Search:

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Linagliptin impurity 15 CPo3604-01 (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester Canagliflozin Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Rivaroxaban 3-(R)-Piperidinyl PhthaliMide D-(-)-tartaric acid Linagliptin Hydroxychloroquine O-Sulfate Linagliptin Impurity D Linagliptin Impurity K Linagliptin iMpurity G Tert-butyl((3s)-1-(7-(but-2-yn-1-yl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-2,6-dioxo-2,3,4,5,6,7-hexahydro-1h-purin-8-yl)piperidin-3-yl)carbaMate Linagliptin iMpurity E Hydroxychloroquine Sulfate EP Impurity A Linagliptin Impurity F

8-BroMo-7-(2-butyn-a-yl)-3,7-dihydro-3-Methyl-1-[(4-Methyl-2-quinazolinyl)Methyl]-1H-purine-2,6-dione

8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquin-azolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dion

8-BroMo-7-(but-2-yn-1-yl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-1H-purine-2,6(3H,7H)-dione

1H-Purine-2,6-dione,8-broMo-7-(2-butynyl)-3,7-dihydro-3-Methyl-1-[(4-Methyl-2-quinazolinyl)Methyl]-

Linagliptin interMediate F

1-[(4-Methylquinazolin-2-yl)Methyl]-3-Methyl-7-(2-butin-1-yl)-8-broMoxanthine

1H-Purine-2,6-dione, 8-bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-

Iinagliptin Intermediate3

8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione

8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquin-azolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-d

8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione

1-[(4-Methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromoxanthine

8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione

8-BroMo-7-but-2-ynyl-3-Methyl-1-(4-Methyquinazolin-2-ylMethyl)-3,7-dihydro-purine-2,6-dione

8-broMo-7-(but-2-ynyl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-1H-purine-2,6(3H,7H)-dione

8-bromo-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione

Linagliptinmothernucleus

Linaint-H

Linagliptin Impurity 32

8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione

Linagliptin-1

8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)

8-bromo-7-(2-butyne)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-xanthine

Linagliptin IntermediateLinagliptin Intermediate

8-BROMO-7-BUT-2-YNYL-3-METHYL-1-(4-METHYL-QUINAZOLIN-2-YLMETHYL)-3,7-DIHYDRO-PURINE-2,6-DIONE 853029-57-9

8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione ISO 9001：2015 REACH

(2-(chloromethyl)-4-methylquinazoline)，8-Bromo-7-but-2-ynyl-3-methyl-1-(4- methyl-quinazolin-2-ylmethyl)-3,7- dihydro-purine-2,6-dione

Linagliptin Impurity 94

1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl...

8-Bromo-7-(2-Butyn-1-Yl)-3,7-Dihydro-3-Methyl-1-[(4-Methyl-2-Quinazolinyl)Methyl]-1H-Purine-2,6-Dione / Linagliptin Intermediate

1H-Imidazole-4-carboxaldehyde,8-methyl-

8- bromo -7-(2- butyn -1- yl) -3,7- dihydro -3- methyl -1-[(4- methyl -2- quinazolinyl) methyl ]-1H- purin -2,6- dione

1-[(4-Methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl) 8-bromoyanthine

8-brom-7- (2-butynyl-1-yl) -3,7-dihydro-3-methyl-1- [(4-methyl-2-quinazolino) methyl] -1H-purine-2,6-dione

Linagliptin intermediate 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromoxanthine

8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dion

Linagliptin Related Compound-11 (Bromo compound)

8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-xanthine

8-Bromo-7-but

LIP-1A IMPURITY

8-Broma-7 -( but-2-yn-1-yl)-3-methyl-1-[[4-methylquinazalin-2-ylimethiyl]-3,7-dihydra-1H-purine-2,6-dione

1-[(4-METHYLQUINAZOLIN-2-YL)METHYL]-3-METHYL-7-(2-

853029-57-9

C20H17BrN6O2

Intermediates

853029-57-9