(6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester
- Product Name
- (6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester
- CAS No.
- 805250-17-3
- Chemical Name
- (6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester
- Synonyms
- CS-1044;SR03298A;SR-03298A;SR 03298A;SR03298A;Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl);Methyl 2,3-dihydro-6-hydroxy-3-benzofuranacetate;Methyl 6-Hydroxy-2,3-dihydrobenzofuran-3-ylacetate;METHYL 2-(6-HYDROXY-2,3-DIHYDROBENZOFURAN-3-YL)ACETATE;Methyl (6-hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetate;-Benzofuranaceticacid,2,3-dihydro-6-hydroxy-,Methylester;Methyl 2-(5-hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetate
- CBNumber
- CB72550670
- Molecular Formula
- C11H12O4
- Formula Weight
- 208.21
- MOL File
- 805250-17-3.mol
(6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester Property
- Boiling point:
- 326.5±42.0℃ (760 Torr)
- Density
- 1.257±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 126.9±21.4℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.77±0.40(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H947905
- Product name
- (6-Hydroxy-2,3-dihydrobenzofuran-3-yl)aceticAcidMethylEster
- Packaging
- 5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- W8545
- Product name
- Methyl2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate
- Packaging
- 25g
- Price
- $1694
- Updated
- 2021/12/16
- Product number
- orb180899
- Product name
- SR03298A
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1949.9
- Updated
- 2021/12/16
- Product number
- 65425
- Product name
- (6-Hydroxy-2,3-dihydrobenzofuran-3-yl)aceticAcidMethylEster
- Packaging
- 5G
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- orb180899
- Product name
- SR03298A
- Purity
- >98%
- Packaging
- 1000mg
- Price
- $3876
- Updated
- 2021/12/16
(6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester Chemical Properties,Usage,Production
Uses
(6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester was used in the synthetic preparation of TAK-875 (T004915), a novel oral medication that has been developed to improve the secretion of insulin in a glucose-dependent manner, which has the potential to improve the control of blood sugar levels without the risk of hypoglycemia.
Synthesis
726174-52-3
805250-17-3
Methyl 2-(6-hydroxybenzofuran-3-yl)acetate (2 g, 9.71 mmol) was used as starting material and dissolved in methanol. A catalytic amount of palladium carbon (0.2 g) was added and three hydrogen substitutions were performed to exclude air. Subsequently, the reaction was stirred at room temperature for 24 h under hydrogen atmosphere. Upon completion of the reaction, the filtration was carried out using diatomaceous earth as a filter aid and the filter cake was washed with an appropriate amount of solvent. The filtrates were combined and the solvent was removed by distillation under reduced pressure to afford the off-white powdery solid product methyl 2,3-dihydro-6-hydroxy-3-coumarone acetate (1.93 g, 95% yield).
References
[1] Patent: CN105566267, 2016, A. Location in patent: Paragraph 0098-0101
[2] Patent: CN105566263, 2016, A. Location in patent: Paragraph 0087-0090
[3] Patent: CN105017242, 2018, B. Location in patent: Paragraph 0083-0086
[4] Patent: WO2008/1931, 2008, A2. Location in patent: Page/Page column 88
[5] Patent: WO2012/72691, 2012, A1. Location in patent: Page/Page column 51
(6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester Preparation Products And Raw materials
Raw materials
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