METHYL 2-AMINO-4-THIAZOLEACETATE
- Product Name
- METHYL 2-AMINO-4-THIAZOLEACETATE
- CAS No.
- 64987-16-2
- Chemical Name
- METHYL 2-AMINO-4-THIAZOLEACETATE
- Synonyms
- METHYL 2-AMINO-4-THIAZOLEACETATE;METHYL 2-AMINOTHIAZOLE-4-ACETATE;Methyl 2-aMinothiazol-4-yl-acetate;METHYL (2-AMINO-4-THIAZOLYL)ACETATE;Methyl 2-amino-4-thiazoleacetate 98%;Methyl 2-(2-aMinothiazol-4-yl)acetate;methyl (2-amino-1,3-thiazol-4-yl)acetate;2-AMino-4-thiazoleacetic acid Methyl ester;METHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE;2-Amino-4-(methylcarboxymethyl)-1,3-thiazole
- CBNumber
- CB0342179
- Molecular Formula
- C6H8N2O2S
- Formula Weight
- 172.2
- MOL File
- 64987-16-2.mol
METHYL 2-AMINO-4-THIAZOLEACETATE Property
- Melting point:
- 112-116 °C(lit.)
- Boiling point:
- 307.3±17.0 °C(Predicted)
- Density
- 1.353±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 3.61±0.10(Predicted)
- Appearance
- Light yellow to light brown Solid
- InChI
- InChI=1S/C6H8N2O2S/c1-10-5(9)2-4-3-11-6(7)8-4/h3H,2H2,1H3,(H2,7,8)
- InChIKey
- XTQKFBGFHDNUFY-UHFFFAOYSA-N
- SMILES
- S1C=C(CC(OC)=O)N=C1N
- CAS DataBase Reference
- 64987-16-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 649724
- Product name
- Methyl 2-amino-4-thiazoleacetate
- Purity
- 98%
- Packaging
- 5g
- Price
- $361
- Updated
- 2023/06/20
- Product number
- 649724
- Product name
- Methyl 2-amino-4-thiazoleacetate
- Purity
- 98%
- Packaging
- 1g
- Price
- $92.8
- Updated
- 2022/05/15
- Product number
- M287285
- Product name
- Methyl 2-amino-4-thiazoleacetate
- Packaging
- 5G
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 9947AB
- Product name
- Methyl2-(2-aminothiazol-4-yl)acetate
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- 045465
- Product name
- Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $118
- Updated
- 2021/12/16
METHYL 2-AMINO-4-THIAZOLEACETATE Chemical Properties,Usage,Production
Uses
Methyl 2-Amino-4-thiazoleacetate is a reactant in the preparation of N-[4-(substituted)-1,3-thiazol-2-yl]-2-(substituted)acetamides as antibacterial agents against S. aureus, E. coli, P. aeruginosa, and K. pneumonia.
Synthesis
67-56-1
29676-71-9
64987-16-2
General procedure for the synthesis of methyl 2-(2-aminothiazol-4-yl)acetate from methanol and 2-aminothiazole-4-acetic acid: to a solution of 2-amino-4-thiazoleacetic acid (20 g, 0.126 mol) in methanol (100 ml) was added slowly and dropwise to concentrated H2SO4 (24 ml) at 0-5 °C. The reaction mixture was heated to reflux for 5 hours. After completion of the reaction, the pH of the reaction mixture was adjusted to 8-9 with NaHCO3 solution, when a colorless precipitate was produced. The precipitate was collected by filtration and dried to give 19.5 g of methyl 2-(2-aminothiazol-4-yl)acetate in 93% yield.
References
[1] Patent: US2010/152188, 2010, A1. Location in patent: Page/Page column 6
[2] Patent: WO2007/17728, 2007, A2. Location in patent: Page/Page column 15
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5408 - 5412
[4] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 1, p. 338 - 349
[5] Synthetic Communications, 2003, vol. 33, # 12, p. 1977 - 1995
METHYL 2-AMINO-4-THIAZOLEACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 2-AMINO-4-THIAZOLEACETATE manufacturers
- Product
- METHYL 2-AMINO-4-THIAZOLEACETATE 64987-16-2
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-18