ChemicalBook > CAS DataBase List > METHYL 2-AMINO-4-THIAZOLEACETATE

METHYL 2-AMINO-4-THIAZOLEACETATE

Product Name
METHYL 2-AMINO-4-THIAZOLEACETATE
CAS No.
64987-16-2
Chemical Name
METHYL 2-AMINO-4-THIAZOLEACETATE
Synonyms
METHYL 2-AMINO-4-THIAZOLEACETATE;METHYL 2-AMINOTHIAZOLE-4-ACETATE;Methyl 2-aMinothiazol-4-yl-acetate;METHYL (2-AMINO-4-THIAZOLYL)ACETATE;Methyl 2-amino-4-thiazoleacetate 98%;Methyl 2-(2-aMinothiazol-4-yl)acetate;methyl (2-amino-1,3-thiazol-4-yl)acetate;2-AMino-4-thiazoleacetic acid Methyl ester;METHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE;2-Amino-4-(methylcarboxymethyl)-1,3-thiazole
CBNumber
CB0342179
Molecular Formula
C6H8N2O2S
Formula Weight
172.2
MOL File
64987-16-2.mol
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METHYL 2-AMINO-4-THIAZOLEACETATE Property

Melting point:
112-116 °C(lit.)
Boiling point:
307.3±17.0 °C(Predicted)
Density 
1.353±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
3.61±0.10(Predicted)
Appearance
Light yellow to light brown Solid
InChI
InChI=1S/C6H8N2O2S/c1-10-5(9)2-4-3-11-6(7)8-4/h3H,2H2,1H3,(H2,7,8)
InChIKey
XTQKFBGFHDNUFY-UHFFFAOYSA-N
SMILES
S1C=C(CC(OC)=O)N=C1N
CAS DataBase Reference
64987-16-2
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-39
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
649724
Product name
Methyl 2-amino-4-thiazoleacetate
Purity
98%
Packaging
5g
Price
$361
Updated
2023/06/20
Sigma-Aldrich
Product number
649724
Product name
Methyl 2-amino-4-thiazoleacetate
Purity
98%
Packaging
1g
Price
$92.8
Updated
2022/05/15
TRC
Product number
M287285
Product name
Methyl 2-amino-4-thiazoleacetate
Packaging
5G
Price
$140
Updated
2021/12/16
AK Scientific
Product number
9947AB
Product name
Methyl2-(2-aminothiazol-4-yl)acetate
Packaging
1g
Price
$81
Updated
2021/12/16
Matrix Scientific
Product number
045465
Product name
Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate
Purity
>95%
Packaging
500mg
Price
$118
Updated
2021/12/16
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METHYL 2-AMINO-4-THIAZOLEACETATE Chemical Properties,Usage,Production

Uses

Methyl 2-Amino-4-thiazoleacetate is a reactant in the preparation of N-[4-(substituted)-1,3-thiazol-2-yl]-2-(substituted)acetamides as antibacterial agents against S. aureus, E. coli, P. aeruginosa, and K. pneumonia.

Synthesis

67-56-1

29676-71-9

64987-16-2

General procedure for the synthesis of methyl 2-(2-aminothiazol-4-yl)acetate from methanol and 2-aminothiazole-4-acetic acid: to a solution of 2-amino-4-thiazoleacetic acid (20 g, 0.126 mol) in methanol (100 ml) was added slowly and dropwise to concentrated H2SO4 (24 ml) at 0-5 °C. The reaction mixture was heated to reflux for 5 hours. After completion of the reaction, the pH of the reaction mixture was adjusted to 8-9 with NaHCO3 solution, when a colorless precipitate was produced. The precipitate was collected by filtration and dried to give 19.5 g of methyl 2-(2-aminothiazol-4-yl)acetate in 93% yield.

References

[1] Patent: US2010/152188, 2010, A1. Location in patent: Page/Page column 6
[2] Patent: WO2007/17728, 2007, A2. Location in patent: Page/Page column 15
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5408 - 5412
[4] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 1, p. 338 - 349
[5] Synthetic Communications, 2003, vol. 33, # 12, p. 1977 - 1995

METHYL 2-AMINO-4-THIAZOLEACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 2-AMINO-4-THIAZOLEACETATE manufacturers

Career Henan Chemical Co
Product
METHYL 2-AMINO-4-THIAZOLEACETATE 64987-16-2
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
KG/T
Release date
2019-12-18

64987-16-2, METHYL 2-AMINO-4-THIAZOLEACETATERelated Search:

Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate Ethyl 2-amino-4-thiazoleacetate EHATA ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE ETHYL 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETATE Ethyl 2-formamidothiazol-4-acetate Ethyl 2-(2-aminothiazol-4-yl)glyoxylate METHYL 2-AMINO-4-THIAZOLEACETATE Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate ETHYL (Z)-(HYDROXYIMINO)[2-(TRITYLAMINO)THIAZOL-4-YL]ACETATE HYDROCHLORIDE BUTTPARK 138\40-43 ETHYL 2-[2-(2,4-DIFLUOROPHENYL)HYDRAZONO]-2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)ACETATE ETHYL 2-(2-[(4-CHLOROBENZOYL)AMINO]-1,3-THIAZOL-4-YL)-2-OXOACETATE ETHYL (2-[(2E)-2-(4-CHLOROBENZYLIDENE)HYDRAZINO]-1,3-THIAZOL-4-YL)ACETATE BUTTPARK 138\40-45 ETHYL 2-(2-[(2-BROMOACETYL)AMINO]-1,3-THIAZOL-4-YL)ACETATE AURORA 2922

  • Methyl 2-aMinothiazol-4-yl-acetate
  • METHYL (2-AMINO-4-THIAZOLYL)ACETATE
  • METHYL (2-AMINO-4-THIAZOLYL)ACETATE, PURISS, 98%
  • 2-Amino-4-(methylcarboxymethyl)-1,3-thiazole
  • METHYL 2-AMINOTHIAZOLE-4-ACETATE
  • METHYL 2-AMINO-4-THIAZOLEACETATE
  • METHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE
  • (2-AMINO-THIAZOL-4-YL)-ACETIC ACID METHYL ESTER
  • Methyl 2-(2-aMinothiazol-4-yl)acetate
  • Methyl 2-amino-4-thiazoleacetate 98%
  • 2-AMino-4-thiazoleacetic acid Methyl ester
  • methyl (2-amino-1,3-thiazol-4-yl)acetate
  • 4-Thiazoleacetic acid, 2-amino-, methyl ester
  • 4-Thiazoleacetic acid, 2-amino-, methyl ester (9CI, ACI)
  • 2-amino-4-Thiazoleacetic acid methyl ester (9CI ACI)
  • Cefoperazone Intermediate 2/Methyl Aminothiazole Acetate/Methyl 2-Amino-4-thiazole Acetate
  • 64987-16-2
  • 64978-16-2
  • Building Blocks
  • Thiazoles
  • Heterocyclic Building Blocks
  • Heterocyclic Compounds
  • Building Blocks
  • Heterocyclic Building Blocks
  • Thiazoles