Ethyl 2-amino-4-thiazoleacetate

Product Name: Ethyl 2-amino-4-thiazoleacetate
CAS No.: 53266-94-7
Chemical Name: Ethyl 2-amino-4-thiazoleacetate
Synonyms: ATAA;EATA;ATHEE;AURORA 8002;cas#53266-94-7;AKOS BBS-00007967;TIMTEC-BB SBB000258;SPECS AB-601/30963022;Aminothiazole ethyl acetate;Ethyl 2-(2-AMinothiazol-4-yl)A
CBNumber: CB5185780
Molecular Formula: C7H10N2O2S
Formula Weight: 186.23
MOL File: 53266-94-7.mol

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Ethyl 2-amino-4-thiazoleacetate Property

Melting point:: 92-94 °C (lit.)
Boiling point:: 318.5±17.0 °C(Predicted)
Density: 1.2900 (rough estimate)
refractive index: 1.5400 (estimate)
Flash point:: 185 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 3.72±0.10(Predicted)
form: Crystalline Powder
color: Slightly yellow to beige
BRN: 139617
InChI: InChI=1S/C7H10N2O2S/c1-2-11-6(10)3-5-4-12-7(8)9-5/h4H,2-3H2,1H3,(H2,8,9)
InChIKey: SHQNGLYXRFCPGZ-UHFFFAOYSA-N
SMILES: S1C=C(CC(OCC)=O)N=C1N
CAS DataBase Reference: 53266-94-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 37/39-26-36
WGK Germany: 3
F: 23
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 220558
Product name: Ethyl 2-aminothiazole-4-acetate
Purity: 99%
Packaging: 50g
Price: $73.4
Updated: 2025/07/31

TCI Chemical

Product number: A0955
Product name: Ethyl (2-Amino-4-thiazolyl)acetate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: A0955
Product name: Ethyl (2-Amino-4-thiazolyl)acetate
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $179
Updated: 2025/07/31

TRC

Product number: E899330
Product name: Ethyl2-Amino-4-thiazoleacetate
Packaging: 25g
Price: $195
Updated: 2021/12/16

TRC

Product number: E899330
Product name: Ethyl2-Amino-4-thiazoleacetate
Packaging: 1g
Price: $120
Updated: 2021/12/16

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Ethyl 2-amino-4-thiazoleacetate Chemical Properties,Usage,Production

Chemical Properties

slightly yellow to beige crystalline powder

Uses

Ethyl 2-Amino-4-thiazoleacetate, is a versatile building block for the synthesis of various pharmaceutical and biologically active compounds including inhibitors and antibiotics. It is used in the synthesis of Cefdinir (C242675) derivatives.

General Description

Ethyl 2-aminothiazole-4-acetate is an organic ligand and possess strong coordination ability and display diverse coordination modes due to the presence of N, O coordination atoms.

Synthesis

29676-71-9

64-17-5

53266-94-7

Thionyl chloride (0.460 mL, 6.321 mmol, 2 eq.) was slowly added to a stirred mixed solution of 2-aminothiazole-4-acetic acid (500 mg, 3.2 mmol) with ethanol (5 mL) at 0 °C. The reaction mixture gradually became clarified, followed by continuous stirring at room temperature for 16 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. For further purification, two solvent exchanges with ethanol were carried out. The final brown oily product ethyl 2-amino-4-thiazoleacetate was obtained in quantitative yield (588 mg). The product was characterized by NMR hydrogen spectroscopy (400 MHz, DMSO-d6): δ 1.17 (3H, broad peak), 3.72 (2H, broad peak), 4.08 (2H, broad peak), 6.68 (1H, broad peak), 9.43 (2H, broad peak). The resulting compounds can be used directly in the subsequent reaction without further purification.

References

[1] Patent: WO2014/153667, 2014, A1. Location in patent: Page/Page column 78; 79
[2] Patent: CN106045937, 2016, A. Location in patent: Paragraph 0018; 0022; 0026
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 24, p. 3843 - 3848
[4] Journal of Agricultural and Food Chemistry, 2006, vol. 54, # 13, p. 4499 - 4505
[5] Tetrahedron Letters, 2000, vol. 41, # 52, p. 10313 - 10317

Ethyl 2-amino-4-thiazoleacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-amino-4-thiazoleacetate Suppliers

Americas 1 Australia 1 Austria 1 Belgium 5 Canada 1 China 185 Europe 4 France 1 Germany 7 India 29 Japan 4 Slovakia 1 Switzerland 4 The Netherlands 2 Ukraine 2 United Kingdom 27 United States 42 Global 317

Zhejiang Huafang Pharmaceutical Co., Ltd

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Ark Pharm, Inc.

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Energy Chemical

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View Lastest Price from Ethyl 2-amino-4-thiazoleacetate manufacturers

Career Henan Chemical Co

Product: Ethyl 2-amino-4-thiazoleacetate 53266-94-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

53266-94-7, Ethyl 2-amino-4-thiazoleacetateRelated Search:

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Ethyl 2-aMino-4-thiazoleacetate, 99% 50GR

(2-AMINO-4-THIAZOLYL)ACETIC ACID ETHYL ESTER

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(2-AMino-1,3-thiazol-4-yl)acetic acid ethyl ester

Ethyl 2-(2-AMinothiazol-4-yl)A

Ethyl 2-aMinothiazole-4-acetate, 98.0%(GC&T

Ethyl 2-aminothiazole-4-acetate 99%

ATAA

AURORA 8002

Ethyl 2-aminothiazol-4-yl-acetate

ETHYL 2-AMINOTHIAZOLE-4-ACETATE

ETHYL (2-AMINO-1,3-THIAZOL-4-YL)ACETATE

ETHYL (2-AMINO-4-THIAZOLYL)ACETATE

ETHYL 2-AMINO-4-THIAZOLEACETATE

ETHYL 2-(2-AMINOTHIAZOL-4-YL) ACETATE

ETHYL-2-(2-AMINOTHIAZOLE-4-YL)ACETATE

ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE

ETHYL-2-(2-AMINO-4-THIAZOLE-4-YL) ACETATE

ethyl 2-(2-amino-1,3-thiazol-4-yl)ethanoate

Ethyl 2-aminothiazole-4-acetate, >=99%

ethyl 2-(2-aminothiazol-4-yl)acetate hydrobromide

2-(2-aminothiazol-4-yl)acetic acid ethyl ester

2-(2-amino-4-thiazolyl)butanoate

EATA Ethyl 2-(2-aminothiazol-4-yl) acetate

AKOS BBS-00007967

SPECS AB-601/30963022

TIMTEC-BB SBB000258

ethyl 2-aminothiazol-4-acetate

EATA

Ethyl 2-(2-Aminothiazole-4-yl)acetate(EATA)

ETHYL 2-AMINOTHIAZOLE-4-ACETATE WACKER&

2-Amino-4-Thiazole acetic acid ethyl ester

2-(2-AMINO-4-THIAZOLYL)ACETIC ACID ETHYL ESTER

2-(2-Aminothiazol-4-yl)-2-oxo-

2-(2-AMINOTHIAZOL-4-YL)-2-OXO-ACETIC ACID/ ATOA

ETHYL-2-(2-AMINOTHIAZOL-4-YL) ACETATE/EATA

2-(2-AMINOTHIAZOLE-4-YL)ACETICACIDETHYLESTER

4-THIAZOLEACETICACID,2-AMINO-,ETHYLESTER

Ethyl 2-amino-4-thiazoleacetate ,99%

2-Aminothiazole-4-acetic acid ethyl ester

Ethyl 2-amino-4-thiazdeacetate

ATHEE

Aminothiazole ethyl acetate

Ethyl (2-Amino-4-thiazolyl)acetate &gt

cas#53266-94-7

2-(2-Aminothiozole-4-yl)acetic acid ethyl ester

Ethyl (2-Aminothiazole-4-yl) Acetate

2-Amino-4-thiazole ethyl acetate

Cefoperazone intermediate 1/Aminothiazole ethyl acetate/2-Amino-4-thiazole ethyl acetate

53266-94-7

53266-97-7

C7H10N2O2S

Heterocyclic Building Blocks

Thiazoles

Building Blocks

Heterocyclic Compounds

(intermediate of cefotiam)

Cephalosporins