2-Chloro-3-fluoropyridin-4-ol
- Product Name
- 2-Chloro-3-fluoropyridin-4-ol
- CAS No.
- 1184172-46-0
- Chemical Name
- 2-Chloro-3-fluoropyridin-4-ol
- Synonyms
- 2-Chloro-3-fluoropyridin-4-ol;2-Chloro-3-fluoro-4-pyridinol;4-Pyridinol, 2-chloro-3-fluoro-;2-CHLORO-3-FLUORO-1H-PYRIDIN-4-ONE;2-Chloro-3-fluoro-4-hydroxypyridine;2-Chloro-3-fluoropyridin-4-ol ISO 9001：2015 REACH
- CBNumber
- CB72553060
- Molecular Formula
- C5H3ClFNO
- Formula Weight
- 147.53
- MOL File
- 1184172-46-0.mol
2-Chloro-3-fluoropyridin-4-ol Property
- Boiling point:
- 351.2±37.0 °C(Predicted)
- Density
- 1.517±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 6.32±0.10(Predicted)
- form
- solid
- color
- White
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C368753
- Product name
- 2-Chloro-3-fluoropyridin-4-ol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H56-7-X3
- Product name
- 2-Chloro-3-fluoro-4-hydroxypyridine
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- C13480
- Product name
- 2-Chloro-3-fluoro-4-hydroxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $106
- Updated
- 2021/12/16
- Product number
- Y3760
- Product name
- 2-Chloro-3-fluoro-4-hydroxypyridine
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- PC51119
- Product name
- 2-Chloro-3-fluoro-4-hydroxypyridine
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
2-Chloro-3-fluoropyridin-4-ol Chemical Properties,Usage,Production
Synthesis
17282-04-1
1184172-46-0
General procedure for the synthesis of 2-chloro-3-fluoro-4-hydroxypyridine: 2-chloro-3-fluoropyridine (2 mmol) was dissolved in anhydrous THF (10 mL) under anhydrous conditions and the solution was cooled to -78 °C. A hexane solution of lithium diisopropylammonium (LDA; 2.2 mmol) was slowly added to this solution at the same temperature. After the reaction mixture was stirred at -78 °C for 2 h, trimethoxyborane (0.48 mL) was added and stirring was continued for 2 h. The reaction mixture was then cooled to -78 °C. Subsequently, peracetic acid (0.72 mL; 32% in dilute acetic acid) was added and the mixture was slowly warmed to 0 °C with stirring and kept for 1 hour. Upon completion of the reaction, the mixture was cooled to 20 °C and aqueous sodium conidiosulfite solution (0.8 g dissolved in 2 mL of water) was added dropwise. The reaction mixture was extracted with ethyl acetate and the organic phases were combined, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography with an eluent ratio of 1:19 methanol:dichloromethane to afford the target product 2-chloro-3-fluoro-4-hydroxypyridine as a white solid in 80% yield. The structure of the product was determined by 1H NMR (d6-DMSO): δ 11.86 (br s, 1H, OH), 7.89 (d, J = 5.3 Hz, 1H, C6-H), 6.95 (t, J = 5.8 Hz, 1H, C5-H); 19F NMR (d6-DMSO): δ 141.29 (s); ESI-MS: 148(M + 1)+ Confirmation.
References
[1] Patent: WO2009/103950, 2009, A1. Location in patent: Page/Page column 22-23
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 2185 - 2195
[3] Dalton Transactions, 2012, vol. 41, # 21, p. 6549 - 6557
[4] Journal of Fluorine Chemistry, 2015, vol. 173, p. 29 - 34
[5] Tetrahedron Letters, 2010, vol. 51, # 40, p. 5230 - 5233
2-Chloro-3-fluoropyridin-4-ol Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Chloro-3-fluoropyridin-4-ol manufacturers
- Product
- 2-Chloro-3-fluoropyridin-4-ol 1184172-46-0
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26
- Product
- 2-Chloro-3-fluoropyridin-4-ol 1184172-46-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-28
- Product
- 2-Chloro-3-fluoropyridin-4-ol 1184172-46-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20