ChemicalBook > CAS DataBase List > 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Product Name: 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine
CAS No.: 733039-20-8
Chemical Name: 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine
Synonyms: Xylose Impurity 9;5-BROMO-2-CHLORO-N-CYCLOPEN;2-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine;5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine;5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine;5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine;5-Bromo-2-chloro-N-cyclopentylamine-4-pyrimidine;4-PyriMidinaMine, 5-broMo-2-chloro-N-cyclopentyl-;(5-Bromo-2-chloro-pyrimidin-4-yl)-cyclopentyl-amine;N-(5-Bromo-2-chloropyrimidin-4-yl)(cyclopentyl)amine
CBNumber: CB72554173
Molecular Formula: C9H11BrClN3
Formula Weight: 276.56
MOL File: 733039-20-8.mol

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5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Property

Boiling point:: 424.0±30.0 °C(Predicted)
Density: 1.643±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 1.22±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H11BrClN3/c10-7-5-12-9(11)14-8(7)13-6-3-1-2-4-6/h5-6H,1-4H2,(H,12,13,14)
InChIKey: DIVUXBABVYOIOT-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Br)C(NC2CCCC2)=N1

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B733030
Product name: 5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine
Packaging: 250mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: Y6372
Product name: 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
Packaging: 5g
Price: $77
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0366826
Product name: 5-BROMO-2-CHLORO-N-CYCLOPENTYLPYRIMIDIN-4-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $504.11
Updated: 2021/12/16

Matrix Scientific

Product number: 096534
Product name: 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
Purity: 95+%
Packaging: 5g
Price: $660
Updated: 2021/12/16

Matrix Scientific

Product number: 096534
Product name: 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
Purity: 95+%
Packaging: 1g
Price: $225
Updated: 2021/12/16

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5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Chemical Properties,Usage,Production

Uses

5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine is an intermediate in the preparation of 2-aminopyridines as cdk4 inhibitors for treating cell proliferative disorders.

Synthesis

36082-50-5

1003-03-8

733039-20-8

5-Bromo-2,4-dichloropyrimidine (45.6 g, 200 mmol) was dissolved in dioxane (400 mL) at room temperature and subsequently cyclopentylamine (20.4 g, 240 mmol) was added to the solution. The reaction mixture was stirred continuously for 6 hours at room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate, washed sequentially with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to afford 5-bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine as a light yellow solid (56 g, 100% yield), which could be used in subsequent reactions without further purification. The product was characterized as follows: 1H NMR (500 MHz, DMSO-d6) δ 8.23 (1H, s), 7.37 (1H, d, J = 7.3 Hz), 4.31 (1H, m), 1.92 (2H, m), 1.71 (2H, m), 1.53-1.59 (4H, m) ppm; LCMS-ESI (POS), m/z [M + H]+: measured value 276.0, calculated value 275.9.

References

[1] Patent: WO2009/85185, 2009, A1. Location in patent: Page/Page column 35
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 8, p. 3430 - 3449
[3] Combinatorial Chemistry and High Throughput Screening, 2017, vol. 20, # 8, p. 703 - 712
[4] Patent: WO2010/20675, 2010, A1. Location in patent: Page/Page column 89
[5] Patent: US2012/115878, 2012, A1. Location in patent: Page/Page column 5-6

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Suppliers

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View Lastest Price from 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 733039-20-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-06-04

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine 733039-20-8
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-13

Henan Fengda Chemical Co., Ltd

Product: 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 733039-20-8
Price: US $10.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-28

733039-20-8, 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMineRelated Search:

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