KW-2478

Product Name: KW-2478
CAS No.: 819812-04-9
Chemical Name: KW-2478
Synonyms: CS-287;KW-2478;KW-2478（b）;KW-2478 USP/EP/BP;KW2478; KW-2478; KW 2478.;2-(2-Ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxye;2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide;2-Ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]benzeneacetamide;2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide;Benzeneacetamide, 2-ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]-
CBNumber: CB72561483
Molecular Formula: C30H42N2O9
Formula Weight: 574.66
MOL File: 819812-04-9.mol

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KW-2478 Property

Density: 1.209
storage temp.: Store at -20°C
solubility: ≥100 mg/mL in DMSO
form: solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22418
Product name: KW 2478
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 22418
Product name: KW 2478
Purity: ≥98%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 22418
Product name: KW 2478
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 22418
Product name: KW 2478
Purity: ≥98%
Packaging: 25mg
Price: $692
Updated: 2024/03/01

TRC

Product number: K660453
Product name: KW-2478
Packaging: 25mg
Price: $935
Updated: 2021/12/16

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KW-2478 Chemical Properties,Usage,Production

Uses

KW-2478 is a novel non-ansamycin potent Hsp90 inhibitor.

Biological Activity

kw-2478 is a novel and potent nonansamycin inhibitor of heat shock protein 90 (hsp90) to overcome the limitations, including low water solubility and hepatotoxicity, of 17-allylamino-17-demethoxygeldanamycin (17-aag). kw-2478 exerts a strong antitumor activity against multiple myeloma (mm) cells with various chromosormal translocation, in which kw-2478 inhibits cell growth and apoptosis associated with hsp90 client protein degradation and the decreasing of igh translocation products including fgfr3, c-maf and cyclin d1. recent study results have revealed that kw-2478 is able to deplete hsp90 client cdk9 and the phosphorylated 4e-bp1, a transcriptional kinase and a transcription inhibitor respectively, leading to the reduced expression of c-maf and cyclin d1.nakashima t, ishii t, tagaya h, seike t, nakagawa h, kanda y, akinaga s, soga s, shiotsu y. new molecular and biological mechanism of antitumor activities of kw-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells. clin cancer res. 2010; 16(10): 2792-802.

target

Hsp90

KW-2478 Preparation Products And Raw materials

Raw materials

Preparation Products

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KW-2478 Suppliers

China 79 India 1 United States 15 Global 95

Shanghai Boyle Chemical Co., Ltd.

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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
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ProdList: 9984
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
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China Kouting Group Limited

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Guangzhou Isun Pharmaceutical Co., Ltd

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AdooQ BioScience, LLC

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ApexBio Technology LLC

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View Lastest Price from KW-2478 manufacturers

Career Henan Chemical Co

Product: KW-2478 819812-04-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-10

819812-04-9, KW-2478Related Search:

BIIB-021 PF-04929113 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide 17-DMAG NVP-BEP800 17-AAG

KW-2478

2-Ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]benzeneacetamide

2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide

2-Ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]benzeneacetamide KW2478

2-(2-Ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxye

CS-287

2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide

KW2478; KW-2478; KW 2478.

Benzeneacetamide, 2-ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]-

KW-2478 USP/EP/BP

KW-2478（b）

819812-04-9

Inhibitor

APIs