ChemicalBook > CAS DataBase List > U0126-EtOH

U0126-EtOH

Product Name: U0126-EtOH
CAS No.: 1173097-76-1
Chemical Name: U0126-EtOH
Synonyms: u 126;Lemod;CS-2415;U0126-EtOH;Depo-Medrin;Depometicort;U0126 Ethanol;U0126 ethanolate;U0126 (U0126-EtOH;U0126-EtOH USP/EP/BP
CBNumber: CB72561498
Molecular Formula: C20H22N6OS2
Formula Weight: 426.56
MOL File: 1173097-76-1.mol

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U0126-EtOH Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: ≥21.33 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
color: white to off-white
InChI: InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3
InChIKey: CFQULUVMLGZVAF-UHFFFAOYSA-N
SMILES: C(O)C.C(C#N)(=C(N)SC1C=CC=CC=1N)C(C#N)=C(N)SC1C=CC=CC=1N

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Safety

HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: U120
Product name: U0126 ethanolate
Purity: ≥98% (HPLC), powder
Packaging: 1 mg
Price: $143
Updated: 2025/07/31

Sigma-Aldrich

Product number: U120
Product name: U0126 ethanolate
Purity: ≥98% (HPLC), powder
Packaging: 5 mg
Price: $366.1
Updated: 2025/07/31

ChemScene

Product number: CS-0173
Product name: U0126-EtOH
Purity: 98.70%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD43319
Product name: U 0126 monoethanolate
Packaging: 10mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: BISN0130
Product name: U0126 Ethanol
Packaging: 5mg
Price: $88
Updated: 2021/12/16

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U0126-EtOH Chemical Properties,Usage,Production

Uses

A chemically synthesized and highly selective inhibitor of both MEK1 and MEK2 with IC50s of 70 nM and 60 nM, respectively.

Definition

ChEBI: U0126.EtOH is an addition compound obtained by combining equimolar amounts of (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile (U0126) and ethanol. An inhibitor of mitogen-activated protein kinase that also exhibits anti-cancer properties. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, an antioxidant, an osteogenesis regulator and a vasoconstrictor agent. It contains an U0126.

Biological Activity

u0126-etoh is a selective inhibitor of mek1 and mek2 with ic50 values of 70 nm and 60 nm, resepctively [1].u0126 was screened out as an anti-inflammatory agent that inhibited ap-1 transcription with ic50 value of 1μm and had no interactions with gres. u0126 binds mek1/2 in a unique site. this inhibition of mek1/2 is noncompetitive with erk and atp. u0126 showed no effects on other mapkks. in ht22 cells, u0126 treatment significantly inhibited the cell injury caused by oxidative glutamate toxicity and remarkably blocked the phosphorylation of erk1/2. besides that, u0126 exerted no neuroprotection against other stimuli such as tnfα and actinomycin d. u0126 treatment also protected the primary cultured cortical neurons from oxidative glutamate toxicity and hypoxia/reoxygenation [1, 2].

in vivo

Mice are treated daily with U0126-EtOH (U0126; i.p., 10.5 mg/kg). In control experiment, tumor sizes are constant or slightly increase all over the kinetic. At the opposite, in all U0126-EtOH experiments, engraftment and early tumor growth are significantly decreased. Furthermore, a 60-70% reduction in the volume of tumors treated with U0126-EtOH is obtained 9 days after injection and thereafter^[3].
Rats are subjected to 120 minutes transient middle cerebral artery occlusion (tMCAO) and thereafter treated with the U0126-EtOH (U0126; i.p., 30 mg/kg) at 0 and 24 hours of reperfusion. After treatment with U0126-EtOH, the vasoconstriction to S6c is markedly reduced^[4].

Animal Model:	Athymic female nude mice (SWISS, nu/nu)^[3].
Dosage:	10.5 mg/kg.
Administration:	Intraperitoneal injection daily.
Result:	Inhibited tumor growth.

Animal Model:	Twelve-week-old female Wistar rats (250 to 265 g)^[4].
Dosage:	30 mg/kg.
Administration:	Intraperitoneally.
Result:	The vasoconstriction to S6c is markedly reduced.

target

MEK1

IC 50

MEK2: 60 nM (IC₅₀); MEK1: 70 nM (IC₅₀)

References

[1] duncia j v, santella iii j b, higley c a, et al. mek inhibitors: the chemistry and biological activity of u0126, its analogs, and cyclization products. bioorganic & medicinal chemistry letters, 1998, 8(20): 2839-2844.
[2] satoh t, nakatsuka d, watanabe y, et al. neuroprotection by mapk/erk kinase inhibition with u0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. neuroscience letters, 2000, 288(2): 163-166.

U0126-EtOH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from U0126-EtOH manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: U0126-EtOH 1173097-76-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

1173097-76-1, U0126-EtOHRelated Search:

LY 294002 Hydrochloride Phenyl carbamate Selumetinib 1,9-Pyrazoloanthrone SB 202190 SB 203580 Rapamycin

CS-2415

u 126

2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile,ethanol

U0126-ETOH;U 0126;U-0126

(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile,ethanol

U0126-EtOH

2,3-Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile ethanol salt

(2Z,3Z)-2,3-Bis(amino(2-aminophenylthio)methylene)succinonitrile compound with ethanol (1:1)

U0126-EtOH, 98%, a high selective MEK1/2 inhibitor

U0126 Ethanol

U0126-EtOH USP/EP/BP

Depo-Medrin

Depometicort

Lemod

U0126-EtOH, a high selective MEK1/2 inhibitor

2,3-Bis(amino((2-aminophenyl)thio)methylene)succinonitrile compound with ethanol (1:1)

Influenza Virus,Mitogen-activated protein kinase kinase,MAP2K,U-0126-EtOH,U0126-EtOH,MEK,inhibit,competitive,virus,Mitophagy,Autophagy,U0126EtOH,MAPKK,Mitochondrial Autophagy,Inhibitor,progeny,non-ATP,U0126 EtOH

U0126-EtOH, 10 mM in DMSO

U0126 ethanolate

U0126 (U0126-EtOH

2,3-Bis(amino((2-aminophenyl)thio)methylene)succinonitrile compound with ethanol

1173097-76-1

C18H16N6S2C2H6O

Inhibitors

MAPK