ChemicalBook > CAS DataBase List > U0126-EtOH

U0126-EtOH

Product Name
U0126-EtOH
CAS No.
1173097-76-1
Chemical Name
U0126-EtOH
Synonyms
u 126;Lemod;CS-2415;U0126-EtOH;Depo-Medrin;Depometicort;U0126 Ethanol;U0126-EtOH USP/EP/BP;U0126-ETOH;U 0126;U-0126;U0126-EtOH, a high selective MEK1/2 inhibitor
CBNumber
CB72561498
Molecular Formula
C20H22N6OS2
Formula Weight
426.56
MOL File
1173097-76-1.mol
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U0126-EtOH Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
≥21.33 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
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Safety

HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0173
Product name
U0126-EtOH
Purity
98.70%
Packaging
10mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD43319
Product name
U 0126 monoethanolate
Packaging
10mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
BISN0130
Product name
U0126 Ethanol
Packaging
5mg
Price
$88
Updated
2021/12/16
ApexBio Technology
Product number
A1337
Product name
U0126-EtOH
Packaging
25mg
Price
$105
Updated
2021/12/16
ChemScene
Product number
CS-0173
Product name
U0126-EtOH
Purity
98.70%
Packaging
50mg
Price
$106
Updated
2021/12/16
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U0126-EtOH Chemical Properties,Usage,Production

Uses

A chemically synthesized and highly selective inhibitor of both MEK1 and MEK2 with IC50s of 70 nM and 60 nM, respectively.

Definition

ChEBI: U0126.EtOH is an addition compound obtained by combining equimolar amounts of (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile (U0126) and ethanol. An inhibitor of mitogen-activated protein kinase that also exhibits anti-cancer properties. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, an antioxidant, an osteogenesis regulator and a vasoconstrictor agent. It contains an U0126.

Biological Activity

u0126-etoh is a selective inhibitor of mek1 and mek2 with ic50 values of 70 nm and 60 nm, resepctively [1].u0126 was screened out as an anti-inflammatory agent that inhibited ap-1 transcription with ic50 value of 1μm and had no interactions with gres. u0126 binds mek1/2 in a unique site. this inhibition of mek1/2 is noncompetitive with erk and atp. u0126 showed no effects on other mapkks. in ht22 cells, u0126 treatment significantly inhibited the cell injury caused by oxidative glutamate toxicity and remarkably blocked the phosphorylation of erk1/2. besides that, u0126 exerted no neuroprotection against other stimuli such as tnfα and actinomycin d. u0126 treatment also protected the primary cultured cortical neurons from oxidative glutamate toxicity and hypoxia/reoxygenation [1, 2].

target

MEK1

References

[1] duncia j v, santella iii j b, higley c a, et al. mek inhibitors: the chemistry and biological activity of u0126, its analogs, and cyclization products. bioorganic & medicinal chemistry letters, 1998, 8(20): 2839-2844.
[2] satoh t, nakatsuka d, watanabe y, et al. neuroprotection by mapk/erk kinase inhibition with u0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. neuroscience letters, 2000, 288(2): 163-166.

U0126-EtOH Preparation Products And Raw materials

Raw materials

Preparation Products

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U0126-EtOH Suppliers

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Nanjing Peiwill Biotechnology Co.,Ltd.
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View Lastest Price from U0126-EtOH manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
U0126-EtOH 1173097-76-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-22

1173097-76-1, U0126-EtOHRelated Search:

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  • CS-2415
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  • 2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile,ethanol
  • U0126-ETOH;U 0126;U-0126
  • (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile,ethanol
  • U0126-EtOH
  • 2,3-Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile ethanol salt
  • (2Z,3Z)-2,3-Bis(amino(2-aminophenylthio)methylene)succinonitrile compound with ethanol (1:1)
  • U0126-EtOH, 98%, a high selective MEK1/2 inhibitor
  • U0126 Ethanol
  • U0126-EtOH USP/EP/BP
  • Depo-Medrin
  • Depometicort
  • Lemod
  • U0126-EtOH, a high selective MEK1/2 inhibitor
  • 2,3-Bis(amino((2-aminophenyl)thio)methylene)succinonitrile compound with ethanol (1:1)
  • Influenza Virus,Mitogen-activated protein kinase kinase,MAP2K,U-0126-EtOH,U0126-EtOH,MEK,inhibit,competitive,virus,Mitophagy,Autophagy,U0126EtOH,MAPKK,Mitochondrial Autophagy,Inhibitor,progeny,non-ATP,U0126 EtOH
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  • Inhibitors
  • MAPK