(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

Product Name: (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide
CAS No.: 334949-59-6
Chemical Name: (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide
Synonyms: BIX02188（b）;Compound T1744;BIX02188, 10 mM in DMSO;BIX 02188, MEK5 inhibitor;(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-, (3Z)-
CBNumber: CB72565885
Molecular Formula: C25H24N4O2
Formula Weight: 412.48
MOL File: 334949-59-6.mol

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(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide Property

Boiling point:: 615.8±55.0 °C(Predicted)
Density: 1.283
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:32.5(Max Conc. mg/mL);78.79(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.21(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);48.49(Max Conc. mM)
form: A crystalline solid
pka: 11.18±0.20(Predicted)
color: Light yellow to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16238
Product name: BIX02188
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16238
Product name: BIX02188
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 16238
Product name: BIX02188
Purity: ≥95%
Packaging: 10mg
Price: $278
Updated: 2024/03/01

Cayman Chemical

Product number: 16238
Product name: BIX02188
Purity: ≥95%
Packaging: 25mg
Price: $586
Updated: 2024/03/01

Axon Medchem

Product number: Axon3346
Product name: BIX02188
Purity: 98%
Packaging: 2x25mg
Price: $616
Updated: 2021/12/16

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(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide Chemical Properties,Usage,Production

Uses

BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM.

IC 50

MEK5: 4.3 nM (IC₅₀); ERK5: 810 nM (IC₅₀); CSF1R (FMS): 280 nM (IC₅₀); LCK: 390 nM (IC₅₀); KIT: 550 nM (IC₅₀); TGFβR1: 1.8 μM (IC₅₀); ABL1: 2.1 μM (IC₅₀); RPS6KA6 (RSK4): 3.2 μM (IC₅₀); RPS6KA3 (RSK2): 4.1 μM (IC₅₀); MAPK14 (p38 alpha): 3.9 μM (IC₅₀); JAK3: 7.8 μM (IC₅₀); SRC: 8.9 μM (IC₅₀)

References

[1] Li L, et al. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23;370(1):159-63. DOI:10.1016/j.bbrc.2008.03.051
[2] Badshah II, et al. Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. Front Pharmacol. 2014 Apr 21;5:71. DOI:10.3389/fphar.2014.00071
[3] Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5. DOI:10.1016/j.bbrc.2008.09.087

(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide Suppliers

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334949-59-6, (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamideRelated Search:

Dimethyl 2,6-Dimethylaniline N,N-Dimethylaniline 2,6-Lutidine

(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-, (3Z)-

Compound T1744

BIX02188（b）

BIX 02188, MEK5 inhibitor

BIX02188, 10 mM in DMSO

334949-59-6

MAPK