AR-M 1000390 hydrochloride
- Product Name
- AR-M 1000390 hydrochloride
- CAS No.
- 209808-47-9
- Chemical Name
- AR-M 1000390 hydrochloride
- Synonyms
- ARM-390;ARM-390HCl;AR-M1000390 HCl;ARM390 Hydrochloride;ARM 390;ARM-390;ARM390;AR-M 1000390 hydrochloride;N,N-Diethyl-4-(phenyl-4-piperidinylideneMethyl)benzaMide Hydrochloride;N,N-Diethyl-4-(phenyl(piperidin-4-ylidene)methyl)benzamide hydrochloride;Benzamide,N,N-diethyl-4-(phenyl-4-piperidinylidenemethyl)-,monohydrochloride;N,N-Diethyl-4-[phenyl(4-piperidinylidene)methyl]benzamide hydroch loride (1:1)
- CBNumber
- CB72565926
- Molecular Formula
- C23H29ClN2O
- Formula Weight
- 384.95
- MOL File
- 209808-47-9.mol
AR-M 1000390 hydrochloride Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- <38.49mg/ml in DMSO; <38.49mg/ml in H2O
- form
- solid
- color
- White
N-Bromosuccinimide Price
- Product number
- 4335
- Product name
- AR-M1000390hydrochloride
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $193
- Updated
- 2021/12/16
- Product number
- 254661
- Product name
- AR-M 1000390 hydrochloride
- Packaging
- 10mg
- Price
- $438
- Updated
- 2021/12/16
- Product number
- D444820
- Product name
- N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamideHydrochloride
- Packaging
- 50mg
- Price
- $605
- Updated
- 2021/12/16
- Product number
- 9731DX
- Product name
- AR-M1000390hydrochloride
- Packaging
- 50mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- CS-0020750
- Product name
- AR-M1000390hydrochloride
- Purity
- 99.80%
- Packaging
- 50mg
- Price
- $490
- Updated
- 2021/12/16
AR-M 1000390 hydrochloride Chemical Properties,Usage,Production
Uses
N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Hydrochloride is a (arylheteroaryl)methylene]piperidine derivatives with analgesic effect.
Biological Activity
ar-m 1000390 hydrochloride is a potent and selective agonist of δ-opioid receptor with ic50 value of 0.87 nm [1].opioid receptor is a g protein-coupled receptor with opioids as ligands. δ-opioid receptor is a opioid receptor with enkephalins as its endogenous ligands and activation of δ-opioid receptor causes analgesia.ar-m 1000390 hydrochloride is a potent and selective δ-opioid receptor agonist with ic50 values of 0.87 nm, 3.8 and 7.47 μm for δ-opioid receptor, μ-opioid receptor and κ-opioid receptor, respectively [1]. in the sk-n-be neuroblastoma cell line, ar-m 1000390 inhibited forskolin-stimulated camp accumulation with ki and ec50 values of 106 and 111 nm, respectively. sustained activation of opioid receptors by ar-m1000390 produced a strong desensitization [2].in dor-egfp mice, arm390 (10 mg/kg) significantly reduced cfa-induced heat hyperalgesia at day 1 and induced complete tolerance at day 5. in arm390-tolerant mice, δ-opioid receptor uncoupled to ca2+ channels in dorsal root ganglia [3].
storage
Store at -20°C
References
[1]. wei zy, brown w, takasaki b, et al. n,n-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. j med chem, 2000, 43(21): 3895-3905.
[2]. marie n, landemore g, debout c, et al. pharmacological characterization of ar-m1000390 at human delta opioid receptors. life sci, 2003, 73(13): 1691-1704.
[3]. pradhan aa, walwyn w, nozaki c, et al. ligand-directed trafficking of the -opioid receptor in vivo: two paths toward analgesic tolerance. j neurosci, 2010, 30(49): 16459-16468.
AR-M 1000390 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
AR-M 1000390 hydrochloride Suppliers
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View Lastest Price from AR-M 1000390 hydrochloride manufacturers
- Product
- AR-M 1000390 hydrochloride 209808-47-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25