CAY10581

Product Name: CAY10581
CAS No.: 1018340-07-2
Chemical Name: CAY10581
Synonyms: CAY10581;CAY10581 Exclusive;2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel-
CBNumber: CB72590430
Molecular Formula: C22H21NO4
Formula Weight: 363.41
MOL File: 1018340-07-2.mol

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CAY10581 Property

Boiling point:: 548.8±50.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
solubility: DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 3 mg/ml
form: A crystalline solid
pka: 12.53±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16838
Product name: CAY10581
Purity: ≥97%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 16838
Product name: CAY10581
Purity: ≥97%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 16838
Product name: CAY10581
Purity: ≥97%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 16838
Product name: CAY10581
Purity: ≥97%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

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CAY10581 Chemical Properties,Usage,Production

Description

The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC₅₀ = 55 nM). It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.

Uses

CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor.

IC 50

IDO: 55 nM (IC₅₀)

References

[1] SANJEEV KUMAR. Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors[J]. Journal of Medicinal Chemistry, 2008, 51 22: 7325. DOI: 10.1021/jm8013053
[2] BENJAMIN J. MOYER . Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor[J]. Toxicology and applied pharmacology, 2017, 323: Pages 74-80. DOI: 10.1016/j.taap.2017.03.012

CAY10581 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10581 Suppliers

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1018340-07-2, CAY10581Related Search:

CAY10581

CAY10581 Exclusive

2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel-

1018340-07-2