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CAY10581

Product Name
CAY10581
CAS No.
1018340-07-2
Chemical Name
CAY10581
Synonyms
CAY10581;CAY10581 Exclusive;2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel-
CBNumber
CB72590430
Molecular Formula
C22H21NO4
Formula Weight
363.41
MOL File
1018340-07-2.mol
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CAY10581 Property

Boiling point:
548.8±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
solubility 
DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 3 mg/ml
form 
A crystalline solid
pka
12.53±0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16838
Product name
CAY10581
Purity
≥97%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16838
Product name
CAY10581
Purity
≥97%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
16838
Product name
CAY10581
Purity
≥97%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
16838
Product name
CAY10581
Purity
≥97%
Packaging
25mg
Price
$618
Updated
2024/03/01
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CAY10581 Chemical Properties,Usage,Production

Description

The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC50 = 55 nM). It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.

Uses

CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor.

IC 50

IDO: 55 nM (IC50)

References

[1] SANJEEV KUMAR. Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors[J]. Journal of Medicinal Chemistry, 2008, 51 22: 7325. DOI: 10.1021/jm8013053
[2] BENJAMIN J. MOYER . Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor[J]. Toxicology and applied pharmacology, 2017, 323: Pages 74-80. DOI: 10.1016/j.taap.2017.03.012

CAY10581 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10581 Suppliers

Canada 1 CHINA 25 India 1 United States 6 Global 33

1018340-07-2, CAY10581Related Search:


  • CAY10581
  • CAY10581 Exclusive
  • 2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel-
  • 1018340-07-2