Phthalazinone pyrazole
- Product Name
- Phthalazinone pyrazole
- CAS No.
- 880487-62-7
- Chemical Name
- Phthalazinone pyrazole
- Synonyms
- Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
- CBNumber
- CB72592005
- Molecular Formula
- C18H15N5O
- Formula Weight
- 317.34
- MOL File
- 880487-62-7.mol
Phthalazinone pyrazole Property
- Boiling point:
- 557.7±52.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO
- form
- crystalline solid
- pka
- 13.83±0.10(Predicted)
- color
- Brown to gray
N-Bromosuccinimide Price
- Product number
- 10735
- Product name
- Phthalazinone pyrazole
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 10735
- Product name
- Phthalazinone pyrazole
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $302
- Updated
- 2024/03/01
- Product number
- 10735
- Product name
- Phthalazinone pyrazole
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $535
- Updated
- 2024/03/01
- Product number
- C3823
- Product name
- Phthalazinonepyrazole
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C3823
- Product name
- Phthalazinonepyrazole
- Packaging
- 5mg
- Price
- $269
- Updated
- 2021/12/16
Phthalazinone pyrazole Chemical Properties,Usage,Production
Description
Three Aurora kinases, A-
in vitro
phthalazinone pyrazole potently inhibited the activity of aurora a kinase with an ic50 of 31 nm. it showed no inhibitory effect on aurora b kinase at doses up to 100 μm. phthalazinone pyrazole inhibited the proliferation of hct116, colo205, and mcf-7 cells with ic50 values of 7.8, 2.9, and 1.6 μm, respectively [1].
References
[1] prime m e, courtney s m, brookfield f a, et al. phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of aurora-a kinase[j]. journal of medicinal chemistry, 2010, 54(1): 312-319.
[2] vader g, lens s m a. the aurora kinase family in cell division and cancer[j]. biochimica et biophysica acta (bba)-reviews on cancer, 2008, 1786(1): 60-72.
Phthalazinone pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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