ChemicalBook > CAS DataBase List > MG149
MG149
- Product Name
- MG149
- CAS No.
- 1243583-85-8
- Chemical Name
- MG149
- Synonyms
- MG 149;CS-1878;MG 149;MG-149;CHEMBL1215739;MG149 USP/EP/BP;Tip60 HAT inhibitor;MG 149, 10 mM in DMSO;CHEMBL1215739; MG 149; MG-149;2-(4-heptylphenethyl)-6-hydroxybenzoic acid;2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-benzoic acid
- CBNumber
- CB72598759
- Molecular Formula
- C22H28O3
- Formula Weight
- 340.46
- MOL File
- 1243583-85-8.mol
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MG149 Property
- Boiling point:
- 477.8±33.0 °C(Predicted)
- Density
- 1.100±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥114 mg/mL in DMSO; ≥30.5 mg/mL in EtOH; insoluble in H2O
- form
- Powder
- pka
- 3.06±0.30(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 22135
- Product name
- MG149
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $43
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22135
- Product name
- MG149
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $167
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22135
- Product name
- MG149
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $290
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22135
- Product name
- MG149
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $570
- Updated
- 2024/03/01
ApexBio Technology
- Product number
- B3276
- Product name
- MG149
- Packaging
- 100mg
- Price
- $679
- Updated
- 2021/12/16
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MG149 Chemical Properties,Usage,Production
Biological Activity
mg 149 is an inhibitor of histone acetyltransferases (hat) with ic50 values of 74μm and 47μm for tip60 and mof, respectively [1].mg 149 is an anacardic acid derivative. it shows selective inhibition towards the myst type of hats: tip60 and mof with ic50 values of 74μm and 47μm, respectively. the docking study shows that the inhibition of tip60 by mg 149 is competitive with respect to ac-coa in the ac-coa binding pocket of tip60. mg 149 also inhibits the activity of hat in nuclear extracts from hela cells using biotinylated histone h3 or histone h4 peptides as substrates. it is found to be more potent for histone h3 compared to histone h4. additionally, dna microarrays demonstrate that mg149 inhibits p53 and nf-kb pathways as well as a very limited number of other pathways [1, 2].
References
[1] ghizzoni m, wu j, gao t, haisma hj, dekker fj, george zheng y. 6-alkylsalicylates are selective tip60 inhibitors and target the acetyl-coa binding site. eur j med chem. 2012 jan;47(1):337-44.
[2] dekker fj, van den bosch t, martin ni. small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. drug discov today. 2014 may;19(5):654-60.
MG149 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MG149 manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- MG 149 1243583-85-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- MG 149 1243583-85-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08