N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine

Product Name: N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine
CAS No.: 267243-68-5
Chemical Name: N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine
Synonyms: Linezolid Impurity 138;Canertinib N-Despropenyl Impurity;N4-(3-chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazol...;N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine;4-N-(3-chloro-4-fluorophenyl)-7-(3-morpholin-4-ylpropoxy)quinazoline-4,6-diamine;4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-;6-amino-4-[N-(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline
CBNumber: CB72602865
Molecular Formula: C21H23ClFN5O2
Formula Weight: 431.89
MOL File: 267243-68-5.mol

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N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine Property

Boiling point:: 613.5±55.0 °C(Predicted)
Density: 1.366±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 7.03±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0369691
Product name: N4-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)QUINAZOLINE-4,6-DIAMINE
Purity: 95.00%
Packaging: 100MG
Price: $414.75
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35965
Product name: N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine
Purity: 95+%
Packaging: 100mg
Price: $545
Updated: 2021/12/16

Matrix Scientific

Product number: 090076
Product name: N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-quinazoline-4,6-diamine
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

Matrix Scientific

Product number: 090076
Product name: N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-quinazoline-4,6-diamine
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

Crysdot

Product number: CD11156094
Product name: N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine
Purity: 95+%
Packaging: 100mg
Price: $81
Updated: 2021/12/16

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N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine Chemical Properties,Usage,Production

Synthesis

267243-64-1

267243-68-5

N-(3-chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine (1.0 eq.) and NiCl2-6H2O (2.0 eq.) were used as raw materials, which were dissolved in a solvent mixture of dichloromethane/methanol (32 mL:8 mL). The reaction mixture was stirred at 0 °C for 5 min, followed by the addition of NaBH4 (4.0 eq.) in batches. After addition, the ice bath was removed and the reaction mixture was allowed to warm naturally to room temperature and stirring was continued for 30 minutes. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by column chromatography (eluent ratio 10:1 dichloromethane/methanol) to afford N-(3-chloro-4-fluorophenyl)-7-(3-morpholino-propoxy)quinazoline-4,6-diamine as a pale yellow solid in 50% yield.1H NMR (500 MHz, DMSO) δ 9.39 (s, 1H), 8.37 (s, 1H), 8.20 (d, J = 4.5 Hz, 1H), 7.81 (d, J = 8.5 Hz, 1H), 7.41-7.38 (m, 2H), 7.08 (s, 1H), 5.35 (s, 2H), 4.20 (t, J = 5.5 Hz, 2H), 3.59 (t, J = 4.5 Hz, 4H), 3.18 (d, J = 5.0 Hz, 2H), 2.40 (s, 4H), 2.01-1.96 (m, 2H).HRMS (ESI): m/z Calculated value (C21H23ClFN5O2 + H)+: 432.1603.Measured value: 432.1613.

References

[1] Patent: US6344455, 2002, B1
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 7, p. 1380 - 1397
[3] Patent: US2014/206687, 2014, A1. Location in patent: Paragraph 0323-0324
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 22, p. 5916 - 5919
[5] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 16, p. 3359 - 3370

N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine Suppliers

China 42 India 1 United States 2 Global 45

XiaoGan ShenYuan ChemPharm co,ltd

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Anqing CHICO Pharmaceutical Co., Ltd.

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shandong XuanHong Pharmaceutical Technology Co.,Ltd

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Shanghai SuperLan Chemcial Technique Centre

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Amadis Chemical Company Limited

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Jiaxing Deyi Chemical Co., Ltd.

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View Lastest Price from N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine manufacturers

Shanghai Rlavie Technology Co ltd

Product: N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine 267243-68-5
Price: US $0.00-0.00/kg
Min. Order: 0.001kg
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-05-09

Career Henan Chemical Co

Product: N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine 267243-68-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 90%-99.9%
Supply Ability: 500kg
Release date: 2019-07-05

267243-68-5, N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMineRelated Search:

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N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine

4-N-(3-chloro-4-fluorophenyl)-7-(3-morpholin-4-ylpropoxy)quinazoline-4,6-diamine

6-amino-4-[N-(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline

Canertinib N-Despropenyl Impurity

4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-

N4-(3-chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazol...

Linezolid Impurity 138

267243-68-5

C21H23ClFN5O2