N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine

Product Name: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine
CAS No.: 179552-75-1
Chemical Name: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine
Synonyms: Dacomitinib Impurity 1;7-Methoxy-N4-(3-chloro-4-fluorophenyl)-4,6-quinazolinediamine;N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine;N4-(3-Chloro-4-fluorophenyl)-7-methoxy-4,6-quinazolinediamine;4-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine;4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-methoxy-;N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine
CBNumber: CB53053697
Molecular Formula: C15H12ClFN4O
Formula Weight: 318.73
MOL File: 179552-75-1.mol

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N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine Property

Boiling point:: 487.3±45.0 °C(Predicted)
Density: 1.458±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 6.03±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 8007CZ
Product name: N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
Packaging: 5g
Price: $305
Updated: 2021/12/16

AK Scientific

Product number: 8007CZ
Product name: N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
Packaging: 25g
Price: $825
Updated: 2021/12/16

Chemenu

Product number: CM142806
Product name: N4-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
Purity: 97%
Packaging: 25g
Price: $505
Updated: 2021/12/16

Crysdot

Product number: CD11228739
Product name: N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
Purity: 97%
Packaging: 25g
Price: $535
Updated: 2021/12/16

Alichem

Product number: 179552751
Product name: N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
Packaging: 25g
Price: $550.8
Updated: 2021/12/16

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N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine Chemical Properties,Usage,Production

Synthesis

179552-74-0

179552-75-1

General procedure for the synthesis of N4-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine from N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4,6-diamine: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine (10 g, 28.6 mmol) was dissolved in ethanol (200 mL) and THF (100 mL) in a solvent mixture. To this solution, water (50 mL) and saturated ammonium chloride solution (50 mL) were sequentially added at room temperature, followed by iron powder (6.5 g, 116 mmol). The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 3 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filter cake was washed with ethanol. Water (100 mL) was added to the filtrate and a yellow-white solid precipitated. The solid was filtered and dried to afford the target compound N4-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine (8 g, 88% yield) as a yellow solid.1H-NMR (400 MHz, DMSO-d6): δ 9.41 (s, 1H), 8.38 (s, 1H), 8.20-8.17 (m, 1H), 7.82- 7.80 (m, 1H), 7.41-7.37 (m, 2H), 5.36 (s, 2H), 3.97 (s, 3H).

References

[1] Patent: US2005/250761, 2005, A1. Location in patent: Page/Page column 22
[2] Patent: WO2018/119441, 2018, A1. Location in patent: Paragraph 00620; 00621
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 7, p. 1495 - 1503
[4] Patent: WO2014/177038, 2014, A1. Location in patent: Paragraph 00194
[5] Patent: CN103987700, 2016, B. Location in patent: Paragraph 0186-0188

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine Suppliers

China 98 India 4 United States 1 Global 103

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

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View Lastest Price from N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine 179552-75-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Nanjing Fred Technology Co., Ltd

Product: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine 179552-75-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-22

Zibo Hangyu Biotechnology Development Co., Ltd

Product: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine 179552-75-1
Price: US $90.00-900.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-27

179552-75-1, N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMineRelated Search:

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N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine

N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine

7-Methoxy-N4-(3-chloro-4-fluorophenyl)-4,6-quinazolinediamine

Dacomitinib Impurity 1

4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-methoxy-

N4-(3-Chloro-4-fluorophenyl)-7-methoxy-4,6-quinazolinediamine

4-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine

179552-75-1

C15H12ClFN4O