N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide

Product Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide
CAS No.: 90357-53-2
Chemical Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide
Synonyms: Bicalutamide Impurity 21;Bicalutamide Impurity 19;4'-Cyano-3'-trifluoromethylmethacryl anilide;N-Methacryloyl-4-cyano-3-trifluoromethylaniline;N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-2-METHACRYLAMIDE;N - (4-Cyano-3-trifluoromethylphenyl) methylacrylamide;N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide;N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide;2-Methyl-N-[(4-cyano-3-trifluoromethyl)phenyl]-propenamide;N-{[4-cyano-3-(trifluoroMethyl)phenyl]Methyl}prop-2-enaMide
CBNumber: CB31011435
Molecular Formula: C12H9F3N2O
Formula Weight: 254.21
MOL File: 90357-53-2.mol

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N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide Property

Melting point:: 137-139 °C
Boiling point:: 395.5±42.0 °C(Predicted)
Density: 1.28
storage temp.: 2-8°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
pka: 12.19±0.70(Predicted)
form: Solid
color: White to Off-White
Stability:: Light Sensitive
InChI: InChI=1S/C12H9F3N2O/c1-7(2)11(18)17-9-4-3-8(6-16)10(5-9)12(13,14)15/h3-5H,1H2,2H3,(H,17,18)
InChIKey: HHWDZLSGDDXUSM-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)(=O)C(C)=C

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Safety

RIDADR: 3077
HS Code: 2926.90.5050
HazardClass: 9
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3188
Product name: N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide
Purity: >98.0%(GC)
Packaging: 1g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: C3188
Product name: N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide
Purity: >98.0%(GC)
Packaging: 5g
Price: $225
Updated: 2025/07/31

TRC

Product number: C988193
Product name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide
Packaging: 25g
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IC58273
Product name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide
Packaging: 5G
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IC58273
Product name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide
Packaging: 10g
Price: $100
Updated: 2021/12/16

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N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide Chemical Properties,Usage,Production

Uses

N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide was used to prepare and observe selective androgen receptor modulator activity.

Synthesis

654-70-6

920-46-7

90357-53-2

Methacryloyl chloride (2.63 mL, 27.16 mmol) was slowly added dropwise to a stirred N,N-dimethylacetamide (14 mL) solution of 4-amino-2-trifluoromethylbenzonitrile (3.4 mmol) under nitrogen protection for a controlled time period of 10 min and the reaction was carried out at room temperature. The progress of the reaction was monitored by TLC for 3 h or overnight (o.n.). Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (100 mL) and washed sequentially with saturated aqueous sodium bicarbonate solution (3 x 25 mL) and cold brine (4 x 50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography to afford N-(4-cyano-3-trifluoromethylphenyl)methacrylamide in white solid form in 95% yield. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 8.06 (d, J = 2.0 Hz, 1H), 7.99 (dd, J = 8.5 Hz, 2.0 Hz, 1H), 7.87 (bs, 1H), 7.82 (d, J = 8.5 Hz, 1H), 5.90-5.88 (m, 1H), 5.63-5.61 (m, 1H). 2.11-2.10 (m, 3H).

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 118, p. 230 - 243
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 5, p. 1028 - 1040
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 13, p. 4020 - 4031
[4] Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 954 - 959
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3857 - 3869

N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide Suppliers

Americas 1 China 146 Europe 1 Germany 2 India 7 Japan 1 United Kingdom 1 United States 11 Global 170

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View Lastest Price from N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-(4-CYANO-3-(TRIFLUOROMETHYL)PHENYL)METHACRYLAMIDE 90357-53-2
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-29

Hangzhou ICH Biofarm Co., Ltd

Product: N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide 90357-53-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000kg
Release date: 2023-06-14

Career Henan Chemical Co

Product: N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide 90357-53-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-03

90357-53-2, N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamideRelated Search:

Methacrylamide Basic Violet 1 Acrylamide Phenylhydrazine 2,2-Dibromo-2-cyanoacetamide N-Isopropylacrylamide POLY(N-ISOPROPYL ACRYLAMIDE) Acetonitrile Methyl acrylate N-Methylolacrylamide N,N'-Methylenebisacrylamide PHENYL VALERATE Methylparaben Kresoxim-methyl Methanol 4-Amino-2-(trifluoromethyl)benzonitrile Methyl Desfluoro Bicalutamide

N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyl-2-Propenamide

N-Methacryloyl-4-cyano-3-trifluoromethylaniline

2-Methyl-N-[(4-cyano-3-trifluoromethyl)phenyl]-propenamide

N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-2-METHACRYLAMIDE

N-{[4-cyano-3-(trifluoroMethyl)phenyl]Methyl}prop-2-enaMide

N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide

<i>N</i>-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide

2-Propenamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyl-

Bicalutamide Impurity 19

Bicalutamide Impurity 21

BIC-1 : N-[4-Cyano-3 (trifluoromethyl)phenyl]-2-methacrylamideQ: What is BIC-1 : N-[4-Cyano-3 (trifluoromethyl)phenyl]-2-methacrylamide Q: What is the CAS Number of BIC-1 : N-[4-Cyano-3 (trifluoromethyl)phenyl]-2-methacrylamide Q: What is the storage condition of BIC-1 : N-[4-Cyano-3 (trifluoromethyl)phenyl]-2-methacrylamide

4-Amino-5-ethylsulfonyl-2-methoxybenzoicacidQ: What is 4-Amino-5-ethylsulfonyl-2-methoxybenzoicacid Q: What is the CAS Number of 4-Amino-5-ethylsulfonyl-2-methoxybenzoicacid Q: What is the storage condition of 4-Amino-5-ethylsulfonyl-2-methoxybenzoicacid Q: What are the applications of 4-Amino-5-ethylsulfonyl-2-methoxybenzoicacid

N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)thio)-2-methylpropanamide

N - (4-Cyano-3-trifluoromethylphenyl) methylacrylamide

4'-Cyano-3'-trifluoromethylmethacryl anilide

90357-53-2

Chemical intermediate for Bicalutamide