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N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

Product Name
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
CAS No.
1139453-98-7
Chemical Name
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Synonyms
Nintedanib-003;Intedanib Impurity 12;Intedanib Impurity 27;Nintedanib Intermediate 1;N,4-Dimethyl-N-(4-nitrophenyl)-1-piperazineacetamide;1-Piperazineacetamide, N,4-dimethyl-N-(4-nitrophenyl)-;N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acet...;N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide;N-Methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide;N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetami...
CBNumber
CB12520770
Molecular Formula
C14H20N4O3
Formula Weight
292.33
MOL File
1139453-98-7.mol
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N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Property

Melting point:
94 - 96°C
Boiling point:
446.9±40.0 °C(Predicted)
Density 
1.230
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
7.43±0.10(Predicted)
form 
Solid
color 
Pale Yellow to Light Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M327435
Product name
N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Packaging
500mg
Price
$460
Updated
2021/12/16
Matrix Scientific
Product number
143764
Product name
N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Purity
95%
Packaging
1g
Price
$778
Updated
2021/12/16
Matrix Scientific
Product number
143764
Product name
N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Purity
95%
Packaging
5g
Price
$1828
Updated
2021/12/16
Chemenu
Product number
CM132303
Product name
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Purity
95%
Packaging
5g
Price
$785
Updated
2021/12/16
Crysdot
Product number
CD11347829
Product name
N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Purity
95+%
Packaging
5g
Price
$831
Updated
2021/12/16
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N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Chemical Properties,Usage,Production

Uses

N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide is used as a reactant in the synthetic preparation of 6-methoxycarbonyl-substituted indolinones, such as Intedanib (I666650), which is a triple angiokinase inhibitor and antitumor agent.

Synthesis

109-01-3

2653-16-9

1139453-98-7

General procedure for the synthesis of N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide from N-methylpiperazine and 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide: 1-methylpiperazine (7.2 mL, 65 mmol) and potassium carbonate (13.8 g, 100 mmol) were dissolved in acetone (200 mL) and subsequently 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide (11.4 g, 50 mmol) was added slowly. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the precipitate was removed by filtration and the filtrate was rotary evaporated to remove the solvent. The residue was dissolved in ethyl acetate (50 mL × 3) and extracted with 20 mL of water. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to give 15 g of the target compound. LC-MS analysis showed m/z = 293 ([M+H]+).

References

[1] Patent: WO2009/71524, 2009, A2. Location in patent: Page/Page column 21-22; 13
[2] Patent: WO2009/71524, 2009, A2. Location in patent: Page/Page column 21-22; 13
[3] Patent: WO2009/71523, 2009, A1. Location in patent: Page/Page column 4; 23-24
[4] Patent: WO2009/71523, 2009, A1. Location in patent: Page/Page column 4; 24
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2015, vol. 58, # 7, p. 308 - 312

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Suppliers

China 100 India 7 United Kingdom 1 United States 6 Global 114
Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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Jinan Trio PharmaTech Co., Ltd.
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0531-88811783
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+86 (531) 55696010 QQ 1762738062
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Chengdu D-innovation Pharmaceutical Co.，LTD
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028-85105512 17802830247
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China
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Syncozymes (Shanghai) Co.,Ltd.
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021-68187180 13681683526
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021-68187179
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Jinan XuanDe Chemical Co., Ltd.
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0531-88803958 18866891188
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18853169188@163.com
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China
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ChemStrong Scientific Co.,Ltd
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0755-28363542
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sales@chem-strong.com
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China
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Lihe Wuhan New Chemical Materials Co., Ltd.
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027-88395709
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027-88391805
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China
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Shanghai KunRaise Chemical Technology Co., Ltd
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+86-021-50935922
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+86-021-33847795
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Shanghai Send Pharmaceutical Technology Co., Ltd.
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021-58088081 Q2635253576
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QQ3382968513
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China
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BOC Sciences
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16314854226
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United States
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View Lastest Price from N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 1139453-98-7
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-13
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 1139453-98-7
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
N,4-Dimethyl-N-(4-nitrophenyl)-1-piperazineacetamide 1139453-98-7
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-11-26

1139453-98-7, N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamideRelated Search:

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