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N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide

Product Name
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
CAS No.
262368-30-9
Chemical Name
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Synonyms
N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide;Nidanib Impurities 61;Nintedanib Impurity 136;Nintedanib Intermediate 2;-N-methyl-2-(4-methylpiperazin-1-yl);N-(4-aminophenyl)-N-4-dimethyl-1-peperazineacetamide;N-(4-Aminophenyl)-N,4-dimethylpiperazine-1-acetamide;1-Piperazineacetamide, N-(4-aminophenyl)-N,4-dimethyl-;N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide;N-(4-Aminophenyl)-N-methyl-2-(4-methyl-1-piperazinyl)acetamide
CBNumber
CB32520769
Molecular Formula
C14H22N4O
Formula Weight
262.35
MOL File
262368-30-9.mol
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N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Property

Melting point:
152 - 154°C
Boiling point:
434.8±40.0 °C(Predicted)
Density 
1.151
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.43±0.10(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C14H22N4O/c1-16-7-9-18(10-8-16)11-14(19)17(2)13-5-3-12(15)4-6-13/h3-6H,7-11,15H2,1-2H3
InChIKey
LBWNQLVDYPNHAV-UHFFFAOYSA-N
SMILES
N1(CC(N(C2=CC=C(N)C=C2)C)=O)CCN(C)CC1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
2299AB
Product name
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Packaging
5g
Price
$96
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-286
Product name
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Packaging
250mg
Price
$136
Updated
2021/12/16
AK Scientific
Product number
2299AB
Product name
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Packaging
25g
Price
$211
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-286
Product name
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Packaging
1g
Price
$312
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0156329
Product name
N-(4-AMINOPHENYL)-N-METHYL-2-(4-METHYLPIPERAZIN-1-YL)ACETAMIDE
Purity
95.00%
Packaging
1MG
Price
$597.89
Updated
2021/12/16
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N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Chemical Properties,Usage,Production

Uses

N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide acts as a reagent for the preparation, angiokinase inhibitory, antitumor activity and pharmacokinectic properties of deuterated derivatives of nintedanib.

Synthesis

109-01-3

2653-16-9

262368-30-9

GENERAL STEPS: 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide (210.0 g, 0.9185 mol) was suspended in toluene (1157.56 mL) and heated to 40 °C. The mixture was then purified by aqueous solution of N-methylpiperazine (252.65 mL, 2.48 eq.). N-methylpiperazine (252.65 mL, 2.48 eq.) was added dropwise over 30 min. The reaction mixture was stirred at 55 °C for 2 hours. After cooling to room temperature, the reaction mixture was washed with water (157.23 mL) and the organic layer was diluted with isopropanol (1075.33 mL). Palladium/carbon catalyst (18.81 g) was added and hydrogenated overnight at 20 °C under 1 bar hydrogen pressure. After the reaction was complete, the catalyst was removed by filtration and the filtrate was concentrated to about 150 mL and ground with ether (120.0 mL). The crystalline product was collected by filtration, washed with ether and dried under vacuum to afford N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 170 g (70.5% yield).

References

[1] Patent: WO2012/68441, 2012, A2. Location in patent: Page/Page column 13; 14

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Suppliers

China 255 India 20 United Kingdom 2 United States 7 Global 284
Jinan XuanDe Chemical Co., Ltd.
Tel
0531-88803958 18866891188
Fax
0531-82777287
Email
18853169188@163.com
Country
China
ProdList
193
Advantage
58
Chengdu D-innovation Pharmaceutical Co.，LTD
Tel
028-85105512 17802830247
Email
baozuqiang@d-innovation.com
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China
ProdList
60
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55
Nanjing CoreTech Biomedical Co,.Ltd
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025-52880806 13770327895
Fax
86-025-52880803
Email
API@core-tech.com.cn
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China
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CHANGZHOU GARDE PHARMTECH CO.,LTD
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18006124028
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gardepharm@163.com
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China
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117
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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44801
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61
Beijing Mediking Biopharm Co., Ltd
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010-81769521,89753524,81760121 15901403431
Fax
+86-10-81769652
Email
sales01@mediking.cn
Country
China
ProdList
99
Advantage
68
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
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China
ProdList
14101
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59
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
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62
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
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55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
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58
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View Lastest Price from N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Nanjing Fred Technology Co., Ltd
Product
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-19
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-09-13

262368-30-9, N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamideRelated Search:

Methyl 2-oxoindole-6-carboxylate CHOLESTEROL ESTERASE Ethylamine FARNESENE 4-Methylmorpholine 1-Ethylpiperazine N-Aminoethylpiperazine 1-Methylpiperazine 1-Acetylpiperazine (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester BIBF-1120 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate Nintedanib Ethanesulfonate Salt N'-(4-Amino-2-cyanophenyl)-N,N-dimethylformamidine N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide

  • N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
  • N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide
  • N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
  • -N-methyl-2-(4-methylpiperazin-1-yl)
  • Nintedanib Intermediate 2
  • N-(4-aminophenyl)-N-4-dimethyl-1-peperazineacetamide
  • N-(4-Aminophenyl)-N-methyl-2-(4-methyl-1-piperazinyl)acetamide
  • 1-Piperazineacetamide, N-(4-aminophenyl)-N,4-dimethyl-
  • N-(4-Aminophenyl)-N,4-Dimethyl-1-Piperazineacetamide(Under Development)
  • N- (4-aminophenyl) -N-methyl-2 - (4-methylpiperazine-1-yl) acetamide
  • N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetami...
  • N-(4-Aminophenyl)-n-methyl-2-(4-methylpiperazin-1-yl)acetamide 95%
  • N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl) acetamide(Nintedanib acetamide compound)
  • Nidanib Impurities 61
  • Nintedanib Impurity 136
  • <i>N</i>-(4-Aminophenyl)-<i>N</i>-methyl-2-(4-methylpiperazin-1-yl)acetamide
  • N-(4-Aminophenyl)-N,4-dimethylpiperazine-1-acetamide
  • 262368-30-9
  • Intermediate of BIBF-1120 and PKI587
  • 262368-30-9