ChemicalBook > CAS DataBase List > N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide

Product Name
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
CAS No.
262368-30-9
Chemical Name
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Synonyms
N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide;Nidanib Impurities 61;Nintedanib Impurity 136;Nintedanib Intermediate 2;-N-methyl-2-(4-methylpiperazin-1-yl);N-(4-aminophenyl)-N-4-dimethyl-1-peperazineacetamide;N-(4-Aminophenyl)-N,4-dimethylpiperazine-1-acetamide;1-Piperazineacetamide, N-(4-aminophenyl)-N,4-dimethyl-;N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide;N-(4-Aminophenyl)-N-methyl-2-(4-methyl-1-piperazinyl)acetamide
CBNumber
CB32520769
Molecular Formula
C14H22N4O
Formula Weight
262.35
MOL File
262368-30-9.mol
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N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Property

Melting point:
152 - 154°C
Boiling point:
434.8±40.0 °C(Predicted)
Density 
1.151
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.43±0.10(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C14H22N4O/c1-16-7-9-18(10-8-16)11-14(19)17(2)13-5-3-12(15)4-6-13/h3-6H,7-11,15H2,1-2H3
InChIKey
LBWNQLVDYPNHAV-UHFFFAOYSA-N
SMILES
N1(CC(N(C2=CC=C(N)C=C2)C)=O)CCN(C)CC1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
2299AB
Product name
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Packaging
5g
Price
$96
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-286
Product name
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Packaging
250mg
Price
$136
Updated
2021/12/16
AK Scientific
Product number
2299AB
Product name
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Packaging
25g
Price
$211
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-286
Product name
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Packaging
1g
Price
$312
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0156329
Product name
N-(4-AMINOPHENYL)-N-METHYL-2-(4-METHYLPIPERAZIN-1-YL)ACETAMIDE
Purity
95.00%
Packaging
1MG
Price
$597.89
Updated
2021/12/16
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N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Chemical Properties,Usage,Production

Uses

N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide acts as a reagent for the preparation, angiokinase inhibitory, antitumor activity and pharmacokinectic properties of deuterated derivatives of nintedanib.

Synthesis

109-01-3

2653-16-9

262368-30-9

GENERAL STEPS: 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide (210.0 g, 0.9185 mol) was suspended in toluene (1157.56 mL) and heated to 40 °C. The mixture was then purified by aqueous solution of N-methylpiperazine (252.65 mL, 2.48 eq.). N-methylpiperazine (252.65 mL, 2.48 eq.) was added dropwise over 30 min. The reaction mixture was stirred at 55 °C for 2 hours. After cooling to room temperature, the reaction mixture was washed with water (157.23 mL) and the organic layer was diluted with isopropanol (1075.33 mL). Palladium/carbon catalyst (18.81 g) was added and hydrogenated overnight at 20 °C under 1 bar hydrogen pressure. After the reaction was complete, the catalyst was removed by filtration and the filtrate was concentrated to about 150 mL and ground with ether (120.0 mL). The crystalline product was collected by filtration, washed with ether and dried under vacuum to afford N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 170 g (70.5% yield).

References

[1] Patent: WO2012/68441, 2012, A2. Location in patent: Page/Page column 13; 14

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Nanjing Fred Technology Co., Ltd
Product
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-19
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-09-13

262368-30-9, N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamideRelated Search:

Methyl 2-oxoindole-6-carboxylate CHOLESTEROL ESTERASE Ethylamine FARNESENE 4-Methylmorpholine 1-Ethylpiperazine N-Aminoethylpiperazine 1-Methylpiperazine 1-Acetylpiperazine (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester BIBF-1120 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate Nintedanib Ethanesulfonate Salt N'-(4-Amino-2-cyanophenyl)-N,N-dimethylformamidine N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide

  • N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
  • N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide
  • N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
  • -N-methyl-2-(4-methylpiperazin-1-yl)
  • Nintedanib Intermediate 2
  • N-(4-aminophenyl)-N-4-dimethyl-1-peperazineacetamide
  • N-(4-Aminophenyl)-N-methyl-2-(4-methyl-1-piperazinyl)acetamide
  • 1-Piperazineacetamide, N-(4-aminophenyl)-N,4-dimethyl-
  • N-(4-Aminophenyl)-N,4-Dimethyl-1-Piperazineacetamide(Under Development)
  • N- (4-aminophenyl) -N-methyl-2 - (4-methylpiperazine-1-yl) acetamide
  • N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetami...
  • N-(4-Aminophenyl)-n-methyl-2-(4-methylpiperazin-1-yl)acetamide 95%
  • N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl) acetamide(Nintedanib acetamide compound)
  • Nidanib Impurities 61
  • Nintedanib Impurity 136
  • <i>N</i>-(4-Aminophenyl)-<i>N</i>-methyl-2-(4-methylpiperazin-1-yl)acetamide
  • N-(4-Aminophenyl)-N,4-dimethylpiperazine-1-acetamide
  • 262368-30-9
  • Intermediate of BIBF-1120 and PKI587
  • 262368-30-9